Results 1 to 10 of about 5,163 (181)

Inference of ceftobiprole susceptibility through surrogate testing of ceftaroline [PDF]

Journal of Clinical Microbiology
Ceftobiprole is an advanced-generation cephalosporin active against methicillin-resistant Staphylococcus aureus and other clinically relevant bacteria.
Helio S. Sader, Rodrigo E. Mendes, David P. Nicolau, Kristie K. Zappas, Mariana Castanheira   +4 more
doaj   +2 more sources

Ceftaroline for Methicillin-Resistant Staphylococcus aureus Endovascular Infection [PDF]

Infectious Diseases and Therapy
Methicillin-resistant Staphylococcus aureus (MRSA) endovascular infections are associated with high mortality. The increasing reports of clinical failure and toxicities associated with first-line vancomycin provide a medical need for alternative ...
Reese A. Cosimi, Kelsey Peña, John L. Lock, Todd Riccobene, Bhavik Nana, George Sakoulas   +5 more
doaj   +2 more sources

Ceftaroline pharmacokinetics/pharmacodynamics in the hollow-fibre model of Mycobacterium abscessus lung disease [PDF]

IJTLD Open
BACKGROUND: Guideline-based therapy (GBT) of Mycobacterium abscessus (MAB) lung disease (LD) achieves a sputum culture conversion rate in ∼35% of patients. The β-lactam antibiotics, imipenem and cefoxitin, are the cornerstone of GBT.
B.E. Ferro, S. Srivastava, T. Gumbo
doaj   +2 more sources

Beyond mecA: a two-tiered mechanism and regulatory rewiring drive high-level ceftaroline resistance in clinical MRSA [PDF]

Antimicrobial Agents and Chemotherapy
High-level resistance to ceftaroline, a fifth-generation β-lactam critical for treating methicillin-resistant Staphylococcus aureus (MRSA), is an emerging threat to global health.
Melissa Sassman, Michele Karolak, Margeurite Dallaire, Claire E. Schaffer, Carlos Gartner, Calvin Vary, Roberto R. Rosato, Adriana E. Rosato   +7 more
doaj   +2 more sources

In vitro susceptibility of ceftaroline against clinically important Gram-positive cocci, Haemophilus species and Klebsiella pneumoniae in Taiwan: Results from the Antimicrobial Testing Leadership and Surveillance (ATLAS) in 2012–2018

Journal of Microbiology, Immunology and Infection, 2021
Background/Purpose: Ceftaroline, with a unique activity against methicillin-resistant Staphylococcus aureus (MRSA), was not launched in Taiwan before 2019. The in vitro susceptibility data of ceftaroline against important Taiwanese pathogens are lacking.
Shio-Shin Jean, Wen-Sen Lee, Wen-Chien Ko, Po-Ren Hsueh   +3 more
doaj   +1 more source

Susceptibility of Clinical Isolates of Staphylococcus aureus to Ceftaroline [PDF]

Journal of Clinical and Diagnostic Research, 2021
Introduction: Methicillin-Resistant Staphylococcus aureus (MRSA) infection is a major global healthcare problem, the prevalence of which varies from 25-50% in India.
Harsha Sreedharan, KB Asha Pai
doaj   +1 more source

Efficacy of ceftaroline and rifampin, alone or combined, in a rat model of methicillin-resistant Staphylococcus epidermidis osteomyelitis without implant

Microbiology Spectrum, 2023
The in vivo efficacy of ceftaroline and rifampin alone or in combination was investigated in an experimental rat model of methicillin-resistant Staphylococcus epidermidis (MRSE) osteomyelitis.
S. Albac, N. Anzala, D. Bonnot, H. Mirfendereski, P. Chavanet, D. Croisier   +5 more
doaj   +1 more source

Spectrum and potency of ceftaroline against leading pathogens causing community-acquired respiratory tract and skin and soft tissue infections in Latin America, 2010

Brazilian Journal of Infectious Diseases, 2013
Ceftaroline, the active metabolite of the prodrug ceftaroline fosamil, is a cephalosporin with in vitro bactericidal activity against Gram-positive organisms, including methicillinsusceptible and -resistant Staphylococcus aureus, β-haemolytic and ...
Robert K. Flamm, Helio S. Sader, Ronald N. Jones   +2 more
doaj   +3 more sources

Use of Ceftaroline in Hospitalized Patients with and without COVID-19: A Descriptive Cross-Sectional Study

Antibiotics, 2021
A single-center cross-sectional study was conducted to describe the use of ceftaroline in a large teaching hospital in Northern Italy, during a period also including the first months of the coronavirus disease 2019 (COVID-19) pandemic.
Daniele Roberto Giacobbe, Chiara Russo, Veronica Martini, Silvia Dettori, Federica Briano, Michele Mirabella, Federica Portunato, Chiara Dentone, Sara Mora, Mauro Giacomini, Marco Berruti, Matteo Bassetti   +11 more
doaj   +1 more source

Evaluation of in vitro activity of ceftaroline against pathogens associated with community-acquired pneumonia: ATLAS program 2017–2019

Journal of Global Antimicrobial Resistance, 2023
: Objectives: Ceftaroline is an important therapeutic option for community-acquired pneumonia (CAP). Antimicrobial susceptibility to ceftaroline and other antimicrobial agents against Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus ...
Eric Utt, Michal Kantecki, Guillermo Cabezas-Camarero, Susanna Esposito   +3 more
doaj   +1 more source