Variable In Vitro Efficacy of Delafloxacin on Multidrug-Resistant Pseudomonas aeruginosa and the Detection of Delafloxacin Resistance Determinants [PDF]
AntibioticsBackground: In this study, molecular mechanisms contributing to delafloxacin resistance in Pseudomonas aeruginosa strains were investigated. Delafloxacin is a recently approved fluoroquinolone currently introduced to clinical applications.
András Kubicskó +5 more
doaj +5 more sources
In Vitro Activity of Delafloxacin Against Corynebacterium spp. [PDF]
AntibioticsBackground/Objectives: The susceptibility of Corynebacterium spp. to antimicrobial agents is species-related, with increasing levels of resistance to fluoroquinolones in several species related to their continued use in clinical practice.
Montserrat Muñoz-Rosa +8 more
doaj +6 more sources
Structural basis of topoisomerase targeting by delafloxacin [PDF]
Nature CommunicationsDelafloxacin is a potent anionic fluoroquinolone approved for the treatment of respiratory infections that acts by trapping the DNA cleavage complexes of bacterial topoisomerase IV and gyrase.
Shabir Najmudin +9 more
doaj +6 more sources
Detection of Delafloxacin Resistance Mechanisms in Multidrug-Resistant Klebsiella pneumoniae [PDF]
AntibioticsBackground: In this study, the mechanisms implicated in delafloxacin resistance in Klebsiella pneumoniae strains were investigated. Delafloxacin is a novel, broad-spectrum fluoroquinolone that has been approved for clinical application.
András Kubicskó +4 more
doaj +5 more sources
Evaluation of cerebrospinal fluid penetration of delafloxacin in a murine model [PDF]
Antimicrobial Agents and ChemotherapyCerebrospinal fluid (CSF) penetration of delafloxacin was evaluated in a murine model. Mice received a single 40 mg/kg intraperitoneal dose. Plasma and CSF samples were collected at five time points over 4 h and analyzed by ultra high-performance liquid ...
Marin Lahouati +4 more
doaj +5 more sources
Delafloxacin suppresses DEPDC1 expression and induces G2/M arrest in non‐small cell lung cancer cells: A drug repurposing study [PDF]
Smart MoleculesEmerging evidence highlights the oncogenic role of the Dishevelled, Egl‐10, and Pleckstrin domains containing 1 (DEPDC1) gene in lung cancer progression, making it an attractive therapeutic target. In this study, we investigated the anti‐cancer potential
Noman Ali +4 more
doaj +3 more sources
Delafloxacin, Finafloxacin, and Zabofloxacin: Novel Fluoroquinolones in the Antibiotic Pipeline [PDF]
Antibiotics, 2021 Novel antimicrobial agents, approved for clinical use in past years, represent potential treatment options for various infections. In this review, we summarize the most important medical and microbiological features of three recently approved ...
Béla Kocsis +2 more
doaj +4 more sources
In vitro antibiofilm and intracellular activity of delafloxacin against Staphylococcus aureus and Staphylococcus epidermidis in bone and joint infections [PDF]
Microbiology SpectrumStaphylococcal bone and joint infections (BJIs) represent significant challenges for treatment. Fluoroquinolone-based combination therapies, especially involving levofloxacin, are pivotal antimicrobials in their management.
Angélique Sion +6 more
doaj +3 more sources
Disproportionality Analysis of Fluoroquinolone‐Associated Peripheral Neuropathy in the FAERS Database (2007–2024) [PDF]
Clinical and Translational ScienceFluoroquinolones (FQs) are among the most frequently prescribed antibiotic classes worldwide. Despite their therapeutic versatility in treating bacterial infections, regulatory authorities recognized risks of persistent and potentially irreversible ...
Nimra Shamim +5 more
doaj +3 more sources
Delafloxacin: design, development and potential place in therapy
Drug Design, Development and Therapy, 2017 Francisco Javier Candel, Marina Peñuelas Department of Clinical Microbiology and Infectious Diseases, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Universidad Complutense, Madrid, Spain ...
Candel FJ, Peñuelas M
doaj +8 more sources