Results 71 to 80 of about 3,289,331 (190)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Rehabilitation of patients after acute intestinal infections [PDF]

, 2017
Дисбіотичні зміни відмічаються у більшості хворих, які перенесли гострі кишкові інфекції (ГКІ), особливо після антибактерійної терапії. При відсутності адекватної корекції вони зберігаються тривало.
Кондрин, О.Є., Дикий, Б.М., Мазурок, У.Я., Пришляк, О.Я.   +3 more
core  

Using the Vesicare scale to assess severity in adult patients with acute intestinal infections [PDF]

, 2021
The article presents the results of the Vesicare scale application in adult patients with acute intestinal infections to assess the severity of the condition.В статье представлены результаты применения шкалы Vesicare у взрослых пациентов с острыми ...
Милушкин, И. С., Khamanova, Yu. B., Чащина, С. Е., Chashchina, S. E., Хаманова, Ю. Б., Milushkin, I. S.   +5 more
core  

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Etiological structure of acute intestinal infections based on the results of exterritorial monitoring

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. Acute intestinal infections cause high morbidity and mortality, especially in Africa and Southeast Asia, where millions of children under the age of five die every year. The Republic of Guinea urgently requires large-scale research aimed at
Maria A. Makarova, Ramatoulay Balde, Lidiya A. Kaftyreva, Zoya N. Matveeva, Samida Kh. Zhamborova   +4 more
doaj   +1 more source

The State of the Intestinal Microflora in Hospitalized Children with Acute Intestinal Infections [PDF]

, 2018
The purpose of this study was to study the state of the intestinal microflora in young children who received inpatient treatment for acute intestinal infections. A study of the microflora in 183 children aged 0 months. up to 3 years of life.
I. B. Israfilbekova, F. V. Gylyndzhova, L. I. Rustamova, M. G. Aliev, M. N. Mamedova, S. M. Faradzheva, Z. M. Kuliyeva, S. F. Suleymanova, С. М. Фараджева, М. Н. Мамедова, И. Б. Исрафилбекова, С. Ф. Сулейманова, Ф. В. Гылынджова, Л. И. Рустамова, З. М. Кулиева, М. Г. Алиев   +15 more
core   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source