Results 81 to 90 of about 280,583 (311)

4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection. [PDF]

, 2017
BackgroundChagas disease, caused by the protozoan Trypanosoma cruzi, is the leading cause of heart failure in Latin America. The clinical treatment of Chagas disease is limited to two 60 year-old drugs, nifurtimox and benznidazole, that have variable ...
Calvet, Claudia Magalhaes, Choi, Jun Yong, de Mesquita, Liliane Batista, de Souza Pereira, Mirian Claudia, Hirata, Ken, Lostracco-Johnson, Sharon, McKerrow, James H, Meuser-Batista, Marcelo, Nogueira, Alanderson, Podust, Larissa M, Roush, William R, Silva, Tatiana Araujo, Siqueira-Neto, Jair Lage, Suzuki, Brian, Thomas, Diane   +14 more
core   +3 more sources

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source

Respiratory antiviral immunity and immunobiotics: Beneficial effects on inflammation-coagulation interaction during influenza virus infection [PDF]

, 2016
Influenza virus (IFV) is a major respiratory pathogen of global importance, and the cause of a high degree of morbidity and mortality, especially in high-risk populations such as infants, elderly, and immunocompromised hosts.
Alvarez, Gladis Susana, Kitazawa, Haruki, Villena, Julio Cesar, Zelaya, María Hortensia del Rosario   +3 more
core   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Intestinal microbiota changes after solid organ transplantation: a systematic review

Clinical and Biomedical Research, 2018
Introduction: The intestinal microbiota may undergo changes after solid organ transplantation. The purpose of this systematic review was to characterize the intestinal microbiota of patients undergoing solid organ transplantation.
Cristina Carra Forte, Elis Forcellini Pedrollo, Gabriela Corrêa Souza, Cristiane Bauermann Leitão   +3 more
doaj   +2 more sources

Prevalence of parasitic infections in HIV-positive patients in southern Ethiopia: A cross-sectional study

Journal of Infection in Developing Countries, 2013
Introduction: Intestinal parasitic infectionsare a major public health burden in tropical countries. Although all HIV/AIDS patients are susceptible to parasitic infections, those having lower immune status are at greater risk.
Sintayehu Fekadu, Kefyalew Taye, Wondu Teshome, Solomon Asnake   +3 more
doaj   +1 more source

Intestinal transplantation [PDF]

, 1994
Intestinal transplantation is often the only alternative form of treatment for patients dependent on total parenteral nutrition for survival.
Andreas G. Tzakis, M.D, Deltz E, Murase N, Satoru Todo, M.D, Starzl TE, Starzl TE, Starzl TE, Thomas E. Starzl, M.D., Ph.D, Todo S, Tzakis AG   +9 more
core   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Peculiarities of Acute Intestinal Infections Epidemic Process in the Khabarovsk Territory under Conditions of Rainfall Flooding

Проблемы особо опасных инфекций, 2014
Analysis of the incidence rate over the past decade as regards acute intestinal infections in the Khabarovsk Territory has revealed unfavorable epidemiological situation on bacterial dysentery, enteric infections of rotavirus and undetermined etiology ...
V. A. Ott
doaj   +1 more source

Rethinking the role of alpha toxin in Clostridium perfringens-associated enteric diseases : a review on bovine necro-haemorrhagic enteritis [PDF]

, 2017
Bovine necro-haemorrhagic enteritis is an economically important disease caused by Clostridium perfringens type A strains. The disease mainly affects calves under intensive rearing conditions and is characterized by sudden death associated with small ...
Deprez, Piet, Ducatelle, Richard, Goossens, Evy, Haesebrouck, Freddy, Pardon, Bart, Valgaeren, Bonnie, Van Immerseel, Filip   +6 more
core   +3 more sources