Results 141 to 150 of about 403,766 (315)

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Relation between rich-club organization versus brain functions and functional recovery after acute ischemic stroke [PDF]

, 2020
Lu Wang, Kui Kai Lau, Leonard SW Li, Yuen Kwun Wong, Christina Yau, Henry K.F. Mak, Edward S. Hui   +6 more
openalex   +1 more source

Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

Advanced Science, EarlyView.
Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini, Taylor V. Brysgel, Ryan J. Rahman, Eno‐Obong Essien, Saw Y. Nwe, Jichuan Wu, Aparajeeta Majumder, Manthan N. Patel, Sachchidanand Tiwari, Carolann L. Espy, Fengyi Dong, Sabrina A. Santos‐De León, Anit Shah, Vladimir V. Shuvaev, Elizabeth D. Hood, Liam S. Chase, Drew Weissman, Jeremy B. Katzen, David B. Frank, Mariko L. Bennett, Oscar A. Marcos‐Contreras, Jacob W. Myerson, Vladimir R. Muzykantov, Sahily Reyes‐Esteves, Jacob S. Brenner   +24 more
wiley   +1 more source

Advances on the application research of cerebral collateral circulation assessment for acute ischemic stroke mechanical thrombectomy

Chinese Journal of Contemporary Neurology and Neurosurgery, 2019
The key to determine the survival time of ischemic penumbra in patients with acute ischemic stroke is the blood supply of collateral artery. The status of cerebral collateral circulation is closely related to the development of acute ischemic stroke, the
Jian WANG, Shuang XIA, Zi-yu QI, Xue-quan FENG   +3 more
doaj  

Study on the correlation between carotid plaque calcification types and acute ischemic stroke

Frontiers in Neurology
IntroductionComputed tomography angiography (CTA) was used to explore the correlation between the calcification types of carotid plaques and ipsilateral acute ischemic stroke.
Tianyu Chu, Zhongping Guo, Yonggang Zhang, Ying Liu, Yan Gu   +4 more
doaj   +1 more source

Neuronal plasma biomarkers in acute ischemic stroke [PDF]

Julia K. Gundersen, Fernando González‐Ortiz, Thomas K. Karikari, Bjørn‐Eivind Kirsebom, Katrin Mertes, Henrik Zetterberg, Hlin Kvartsberg, Ole Morten Rønning, Berglind Gísladóttir, Kaj Blennow, Tormod Fladby   +10 more
openalex   +1 more source

Left ventricular apical thrombus after systemic thrombolysis with recombinant tissue plasminogen activator in a patient with acute ischemic stroke [PDF]

, 2005
Florian Doepp, Wasiem Sanad, Stephan J. Schreiber, Gert Baumann, Adrian C. Borges   +4 more
openalex   +1 more source

Relationship between the degree of recanalization and functional outcome in acute ischemic stroke is mediated by penumbra salvage volume [PDF]

, 2021
Gabriel Broocks, Hashim Jafarov, Rosalie McDonough, Friederike Austein, Lukas Meyer, Matthias Bechstein, Noel van Horn, Marie Teresa Nawka, Gerhard Schön, Jens Fiehler, Helge Kniep, Uta Hanning   +11 more
openalex   +1 more source

Brd4 BD1 Domain Antagonism of MS436 Preserves Blood‐Brain Barrier Integrity via Rnf43/β‐Catenin Signaling Pathway

Advanced Science, EarlyView.
MS436 competitively binds to the BD1 domain of Brd4, thereby suppressing Brd4 induced degradation of tight junction proteins via the Rnf43‐Fzd4‐β‐catenin signaling pathway. Consequently, this attenuation of degradation reduces blood‐brain barrier leakage, leading to an improved overall prognosis after stroke.
Chenxiao Li, Xiaochen Zhang, Jiangwei Xia, Shuang Liu, Yushan Du, Sihan Li, Shukui Zhang, Yong Zhang, Fen Ji, Jianwei Jiao, Jingjing Zhang   +10 more
wiley   +1 more source

Effects of alteplase in the treatment of acute ischemic stroke

, 2012
Josef Yayan
openalex   +2 more sources