Results 121 to 130 of about 245,314 (316)

Associations of inflammatory and hemostatic variables with the risk of recurrent stroke [PDF]

, 2005
<p><b>Background and Purpose:</b> Several prospective studies have shown significant associations between plasma fibrinogen, viscosity, C-reactive protein (CRP), fibrin D-dimer, or tissue plasminogen activator (tPA) antigen and the risk
Lowe, G.D.O., Woodward, M, A. Rumley, Neal, BC, B. C. Neal, Patel, A., M. Woodward, G. D.O. Lowe, Rumley, A., Kemp, B.E., Colman, S, Chalmers, J, Jenkins, AJ, MacMahon, Stephen, A. J. Jenkins, Jenkins, A.J., Kemp, BE, S. W. MacMahon, Woodward, M., Chalmers, J., Lowe, GD, D. J. Campbell, MacMahon, SW, Neal, B.C., Campbell, DJ, A. Patel, MacMahon, S.W., Patel, A, S. Colman, Campbell, D.J., B. E. Kemp, J. Chalmers, Rumley, A, Colman, S.   +33 more
core   +1 more source

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

Clinical Variables and Genetic Risk Factors Associated with the Acute Outcome of Ischemic Stroke: A Systematic Review [PDF]

, 2019
Stroke is a complex disease and one of the main causes of morbidity and mortality among the adult population. A huge variety of factors is known to influence patient outcome, including demographic variables, comorbidities or genetics.
Cárcel-Márquez, Jara, Ibáñez, Laura, Heitsch, Laura, Torres-Águila, Nuria P., Montaner, Joan, Cullell, Nàtalia, Delgado, Pilar, Delgado Martínez, María Pilar, Fernández-Cadenas, Israel, Carrera, Caty, González-Sánchez, Jonathan, Marti-Fabregas, Joan, Muiño, Elena, Cruchaga, Carlos, Torres-Aguila, Nuria P.., Acute Endophenotypes Group of the International Stroke Genetics Consortium (ISGC), Bustamante, Alejandro, Lee, Jin-Moo, Gallego-Fabrega, Cristina, Universitat Autònoma de Barcelona, Krupinski, Jerzy, Torres-Aguila, Nuria P   +21 more
core   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Increased Expression of Cell-Cell Signaling Genes by Stimulated Mononuclear Leukocytes in Patients with Previous Atherothrombotic Stroke A Whole Genome Expression Profile Study [PDF]

, 2009
Background/Aims: Inflammation plays an important role in atherosclerosis and stroke. Acute infections are recognized as trigger factors for ischemic stroke. Methods: In this whole genome expression profile study of 15 patients and 15 control subjects, we
Wiest, Tina, Horstmann, Solveig, Honold, Cornelius, Hergenhahn, Manfred, Mansmann, Ulrich, Wagner, Simone, Weninger, Annette, Pfleger, Karin, Grond-Ginsbach, Caspar, Hollstein, Monika, Grau, Armin J., Hummel, Manuela, Knyazev, Yuri   +12 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

NXY-059 for Acute Ischemic Stroke

, 2006
Background NXY-059 is a free-radical–trapping agent that is neuroprotective in animal models of stroke. We tested whether it would reduce disability in humans after acute ischemic stroke.
ASHWOOD T, DAVIS, S. M, LYDEN P, CAROLEI, ANTONIO, ISCHEMIC NXY TREATMENT SAINT I. TRIAL INVESTIGATORS, GROTTA J, DIENER H. C, WASIEWSKI W. W. FOR THE STROKE ACUTE, HÅRDEMARK H. G, LEES K. R, ZIVIN J. A, DAVALOS A, SHUAIB A   +12 more
core   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source