Results 81 to 90 of about 245,314 (316)

NXY-059 for the treatment of acute stroke: pooled analysis of the SAINT I and II trials [PDF]

, 2008
<p><b>Background and Purpose:</b> In animal models of acute ischemic stroke (AIS), the free radical-trapping agent NXY-059 showed promise as a neuroprotectant.
Lees, K.R., Shuaib, A., Diener, H.C., Alderfer, V., Davis, S.M., Wasiewski, W., Lyden, P., Rodichok, L., Ashwood, T., Hardemark, H.G., Davalos, A., Grotta, J.   +11 more
core   +1 more source

Reperfusion‐Dependent Outcomes After Endovascular Thrombectomy Stratified by NIHSS‐ASPECTS Clinical‐Core Mismatch

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This analysis evaluates the effect of successful reperfusion on functional outcomes after MT, stratified by admission National Institutes of Health Stroke Scale (NIHSS) and Alberta Stroke Program Early CT Score (ASPECTS) as surrogates for clinical‐core mismatch, using multicenter registry data.
Felix Schlicht, Lukas Meyer, Gabriel Broocks, Matthias Bechstein, Christian Thaler, Christian Heitkamp, Laurens Winkelmeier, Vincent Geest, Alexander Heitkamp, Maximilian Jungnitz, Gregor Peter, Luca Meucci, Tobias Faizy, Jawed Nawabi, Caspar Brekenfeld, Fabian Flottmann, Maximilian Schell, Alexandros Hadjilaou, Uta Hanning, Götz Thomalla, Jens Fiehler, Susanne Gellißen, Helge C. Kniep, for the German Stroke Registry Endovascular Treatment, (GSR‐ET) Alexander Nave, Anna Alegiani, Annerose Mengel, Arno Reich, Bernd Eckert, Charlotte Pietrock, Christian Nolte, Eberhard Siebert, Fabian Flottmann, Fee Keil, Franziska Dorn, Gabor Petzold, Götz Thomalla, Hanna Zimmermann, Jan Borggrefe, Jan Hendrik Schäfer, Jens Fiehler, Joachim Röther, Klaus Gröschel, Lars Kellert, Mario Abruscato, Maximilian Schell, Omid Nikoubashman, Peter Schellinger, Silke Wunderlich, Steffen Tiedt, Sven Thonke, Timo Uphaus, Tobias Boeckh‐Behrens, Ulrike Ernemann   +53 more
wiley   +1 more source

Diagnostic performance of plasma D-dimer, fibrinogen, and D-dimer to fibrinogen ratio as potential biomarkers to predict hypertension-associated acute ischemic stroke

Heliyon
Background: Ischemic stroke is a common type of stroke that leads to death and functional disability in hypertensive patients. However, there are no well-studied non-invasive and less expensive fluid biomarkers routinely used to detect ischemic stroke in
Endeshaw Chekol Abebe, Tadesse Asmamaw Dejenie, Denekew Tenaw Anley, Misganaw Asmamaw Mengstie, Natnael Atnafu Gebeyehu, Getachew Asmare Adella, Gizachew Ambaw Kassie, Natnael Amare Tesfa, Molalegn Mesele Gesese, Sefineh Fenta Feleke, Melkamu Aderajew Zemene, Anteneh Mengist Dessie, Wubet Alebachew Bayih, Yenealem Solomon Kebede, Berihun Bantie, Mohammed Abdu Seid, Engidaw Fentahun Enyew, Gashaw Dessie, Dagnew Getnet Adugna, Teklie Mengie Ayele, Assefa Agegnehu Teshome, Fitalew Tadele Admasu   +21 more
doaj   +1 more source

Multivariable analysis of outcome predictors and adjustment of main outcome results to baseline data profile in randomized controlled trials: Safe Implementation of Thrombolysis in Stroke-MOnitoring STudy (SITS-MOST) [PDF]

, 2008
<p><b>Background and Purpose:</b> The Safe Implementation of Thrombolysis in Stroke-MOnitoring STudy (SITS-MOST) unadjusted results demonstrated that intravenous alteplase is well tolerated and that the effects were comparable with ...
Wahlgren, N., Dávalos A, Hennerici MG, Kaste, M., N. Eriksson, Toni, Danilo, Bluhmki, Erich, N. Wahlgren, Hacke, Werner, Köhrmann, Martin, M. Kaste, Eriksson, Niclas, Aichner F, Ahmed N, Hacke W, Eriksson, N., Koehrmann, M., Bluhmki E, Grond M, F. Aichner, V. Larrue, G. A. Ford, D. Toni, Kaste M, Larrue, Vincent, Erila, T., Larrue, V., Eriksson, Niclas,, Aichner, F., M. G. Hennerici, Wahlgren, Nils, Davalos, A., Ford, Gary A, Grond, M., Toni, D., K. R. Lees, null null, Hennerici, Michael G, T. Erila, Roine, Risto O, Hacke, W., Koehrmann, Martin, Davalos, Antoni, Eriksson N, W. Hacke, Larrue V, Erilä, Terttu, A. Davalos, Aichner, Franz, Bluhmki, E., Wahlgren N, Roine RO, Machnig, T., M. Grond, Vanhooren, Geert, Ford, G.A., Roine, R.O., Hennerici, Michael G., Lees, K.R., Roine, Risto O., E. Bluhmki, Hennerici, M.G., Lees KR, Grond, Martin, Kaste, Markku, Köhrmann M, Peeters, André, Ahmed, Niaz, Machnig, Thomas, Machnig T, Vanhooren G., Erilä T, M. Kohrmann, Ahmed, N., R. O. Roine, Lees, Kennedy R., Ford GA, G. Vanhooren, Vanhooren, G., Lees, Kennedy R, Ford, Gary A., T. Machnig, N. Ahmed   +82 more
core   +1 more source

IV Thrombolysis Facilitates Interventional Reperfusion in Non‐Cardioembolic but Not Cardioembolic Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intravenous thrombolysis (IVT) before thrombectomy for ischemic stroke may alter clot structure and procedural performance. We investigated how IVT relates to thrombectomy metrics across stroke etiologies. Methods We performed a time‐to‐event analysis of consecutive patients with anterior circulation large vessel occlusion (acLVO ...
Annahita Sedghi, Daniel P. O. Kaiser, Martin Arndt, Norma J. Diel, Erik Simon, Witold H. Polanski, Volker Puetz, Hagen B. Huttner, Timo Siepmann   +8 more
wiley   +1 more source

Cardiac thrombus detected by cardiac computed tomography angiography in patients with acute ischemic stroke: a meta-analysis

Frontiers in Neurology
BackgroundDetecting cardiac thrombus in patients with acute ischemic stroke is crucial in determine stroke etiology and predict prognosis. However, the prevalence of cardiac thrombus in patients with acute ischemic stroke is unclear.ObjectThis study ...
Buyun Xu, Buyun Xu, Ye Du, Zhangjie Yu, Yong Sun, Meixiang Xiang   +5 more
doaj   +1 more source

Role of SH levels and markers of immune response in the stroke [PDF]

, 2013
Background. Sulfhydryl groups (SH) are considered a key factor in redox sensitive reaction of plasma, and their modification could be considered an expression of abnormal generation of oxygen free radicals. Methods. Fifty consecutive patients with acute
Arru, Giannina, Gervasoni Jacopo, D’Addessi A, Minucci, Angelo, Fois, Maria Laura, Sotgiu, Stefano, Schiattarella Arcangelo, Cocci A, Angeletti, Silvia, Schiattarella, Arcangelo, Musumeci, Maria, Gambaro Giovanni, Persichilli S, Fois ML, Persichilli, Silvia, Musumeci, Salvatore, Primiano, Aniello, Ferraro Pm, Minucci A, Musumeci M, Angeletti S, Gambaro, Giovanni, Gervasoni, Jacopo, Ferraro, Pietro Manuel, Persichilli Silvia, Musumeci S., Primiano Aniello   +26 more
core   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

Effectiveness of alteplase in the very elderly after acute ischemic stroke

Clinical Interventions in Aging, 2013
Josef Yayan Department of Internal Medicine, University Hospital of Saarland, Homburg/Saar, Germany Abstract: Alteplase has traditionally been the only pharmacologic agent available for treating acute ischemic stroke worldwide, and is considered an ...
Yayan J
doaj  

Stroke penumbra defined by an MRI-based oxygen challenge technique: 1. validation using [14C]2-deoxyglucose autoradiography [PDF]

, 2011
Accurate identification of ischemic penumbra will improve stroke patient selection for reperfusion therapies and clinical trials. Current magnetic resonance imaging (MRI) techniques have limitations and lack validation.
Robertson, Craig A, Robertson, Craig A., William M Holmes, Celestine Santosh, Macrae, I Mhairi, McCabe, Chris, Maria del Rosario Lopez-Gonzalez, Lopez-Gonzalez, Maria del., Barrie Condon, Keith W Muir, Lindsay Gallagher, Holmes, William M., Christopher McCabe, Santosh, Celestine, Craig A Robertson, Lopez-Gonzalez, Maria del Rosario, Holmes, William M, Macrae, I. Mhairi, I Mhairi Macrae, Gallagher, Lindsay, Muir, Keith W, Condon, Barrie, McCabe, Christopher, Muir, Keith W.   +23 more
core   +1 more source