Results 71 to 80 of about 707,511 (342)

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Biomarkers of Acute Kidney Injury [PDF]

Journal of Toxicology, 2011
Acute kidney injury (AKI) is a common problem in both the inpatient and outpatient setting and often results from drug toxicities. Traditional methods of identifying AKI, through measurement of blood urea nitrogen and serum creatinine, are problematic in that they are slow to detect decreases in glomerular filtration rate (GFR) and are influenced by a ...
Charles L. Edelstein, Jelena Klawitter, Jeffrey C. Sirota   +2 more
openaire   +4 more sources

HMGB1 Derived from the Pyroptotic Microenvironment Promotes Macrophage Extracellular Traps in Hirschsprung‐Associated Enterocolitis

Advanced Biology, EarlyView.
HMGB1 derived from the pyroptotic environment in Hirschsprung‐associated enterocolitis mediates the formation of macrophage extracellular traps through TLR4 ‐p38 MAPK/p65 NF‐kB signaling pathways. Macrophage extracellular traps induce increased ROS production and pyroptosis of colonic epithelial cells.
Rui Zhang, Jing Li, Lili Song, Liya Pan, Chengchen Zhang, Zhiyan Zhan, Li Hong   +6 more
wiley   +1 more source

Review of the limitations of current biomarkers in acute kidney injury clinical practices

SAGE Open Medicine
Acute kidney injury is a prevalent disease in hospitalized patients and is continuously increasing worldwide. Various efforts have been made to define and classify acute kidney injury to understand the progression of this disease. Furthermore, deviations
Kendra B Bufkin, Zubair A Karim, Jeane Silva   +2 more
doaj   +1 more source

INCIDENCE AND DIFFERENT RISK FACTORS OF CARDIAC SURGERY ASSOCIATED ACUTE KIDNEY INJURY

Pakistan Armed Forces Medical Journal, 2020
Objective: To identify the incidence of cardiac surgery associated acute kidney injury and its association with different risk factors. Study Design: Descriptive cross sectional study.
Lubna Shaheen, Dr Amna, Syed Shaheer Haider Bukhari, Rehana Javaid, Rashad Sidiqui   +4 more
doaj   +1 more source

Incidence and outcome of early acute kidney injury in critically-ill trauma patients. [PDF]

PLoS ONE, 2013
OBJECTIVE: To determine the incidence and effect on mortality of early acute kidney injury in severely injured trauma patients using the Acute Kidney Injury Network creatinine criteria.
Amber S Podoll, Rosemary Kozar, John B Holcomb, Kevin W Finkel   +3 more
doaj   +1 more source

Association Between Acute Kidney Injury During Invasive Mechanical Ventilation and ICU Outcomes and Respiratory System Mechanics

Critical Care Explorations, 2022
OBJECTIVES:. Compare ICU outcomes and respiratory system mechanics in patients with and without acute kidney injury during invasive mechanical ventilation. DESIGNS:. Retrospective cohort study. SETTINGS:.
Sneha V. Vemuri, MBChB, Mark L. Rolfsen, MD, Alexandra V. Sykes, MD, Puja G. Takiar, MD, Austin J. Leonard, BA, Atul Malhotra, MD, Roger G. Spragg, MD, Etienne Macedo, MD, PhD, Mark L. Hepokoski, MD   +8 more
doaj   +1 more source

Acute toxic kidney injury [PDF]

Renal Failure, 2019
Substances toxic to the kidney are legion in the modern world. The sheer number and variety, their mutual interactions and, metabolism within the body are a challenge to research. Moreover, the kidney is especially prone to injury owing to its physiology.
Nadezda Petejova, Nadezda Petejova, Vladimír Teplan, Josef Zadrazil, Arnošt Martínek   +4 more
openaire   +4 more sources

Microphysiological Glomerular Filtration Barriers: Current Insights, Innovations, and Future Applications

Advanced Biology, EarlyView.
The glomerular filtration barrier (GFB) is the first step of blood filtration by the kidneys. The concerning increase of kidney diseases makes the development of new models essential. In this context, microphysiological glomerular filtration barriers focus on closely reproducing the physiological architecture of the in vivo GFB: podocytes, glomerular ...
Manon Miran, Kieu Ngo, David Buob, Hanna Debiec, Pierre Ronco, Guillaume Perry   +5 more
wiley   +1 more source

Assessment of Acute Kidney Injury and Longitudinal Kidney Function After Hospital Discharge Among Patients With and Without COVID-19

JAMA Network Open, 2021
Key Points Question What is the association between coronavirus disease 2019 (COVID-19) in patients with acute kidney injury and the longitudinal trajectory of estimated glomerular filtration rate?
James B. Nugent, Abinet M. Aklilu, Yu Yamamoto, M. Simonov, Fan Li, Aditya Biswas, Lama Ghazi, J. Greenberg, Sherry G. Mansour, D. Moledina, F. Wilson   +10 more
semanticscholar   +1 more source