Results 71 to 80 of about 1,038,120 (393)

Roles of DNA damage in renal tubular epithelial cells injury

Frontiers in Physiology, 2023
The prevalence of renal diseases including acute kidney injury (AKI) and chronic kidney disease (CKD) is increasing worldwide. However, the pathogenesis of most renal diseases is still unclear and effective treatments are still lacking.
Peipei Wang, Peipei Wang, Peipei Wang, Jing Ouyang, Jing Ouyang, Jing Ouyang, Zhanjun Jia, Zhanjun Jia, Zhanjun Jia, Aihua Zhang, Aihua Zhang, Aihua Zhang, Yunwen Yang, Yunwen Yang, Yunwen Yang   +14 more
doaj   +1 more source

Single-nuclear transcriptomics reveals diversity of proximal tubule cell states in a dynamic response to acute kidney injury

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance A single acute kidney injury event increases the risk of progression to chronic kidney disease (CKD). Combining single-nucleus RNA sequencing with genetic tracing of injured proximal tubule cells identified a spatially dynamic, evolving ...
Louisa M. S. Gerhardt, Jing Liu, Kari Koppitch, Pietro E. Cippà, A. McMahon   +4 more
semanticscholar   +1 more source

Clinical and Laboratory Characteristics of Acute Kidney Injury in Critically Ill Children: A Single Center Study [PDF]

Journal of Pediatrics Review, 2023
Background: Acute kidney injury stands out as one of the common complications in the pediatric intensive care unit.  Objectives: This study was designed to evaluate acute kidney injury’s frequency, etiologies, and its course in critically ill children ...
Faeghe Baryar Langroudi, Hamid Mohammadjafari, Hani Rostami Rad, Mohaddeseh Momeni, Maedeh Guran, Mohammad Reza Navaeifar   +5 more
doaj  

Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury.

New England Journal of Medicine, 2020
Background Acute kidney injury is common in critically ill patients, many of whom receive renal-replacement therapy. However, the most effective timing for the initiation of such therapy remains uncertain. Methods We conducted a multinational, randomized,
Starrt-Aki Investigators, S. Bagshaw, R. Wald, N. Adhikari, R. Bellomo, Bruno R. da Costa, D. Dreyfuss, Bin Du, M. Gallagher, S. Gaudry, E. Hoste, François Lamontagne, M. Joannidis, G. Landoni, Kathleen D. Liu, D. McAuley, S. McGuinness, Javier A. Neyra, A. Nichol, M. Ostermann, P. Palevsky, V. Pettilä, J. Quenot, H. Qiu, B. Rochwerg, Antoine G. Schneider, Orla M. Smith, Fernando Thomé, Kevin E Thorpe, S. Vaara, Matthew Weir, A. Wang, Paul J. Young, Alexander Zarbock   +33 more
semanticscholar   +1 more source

Acute toxic kidney injury [PDF]

Renal Failure, 2019
Substances toxic to the kidney are legion in the modern world. The sheer number and variety, their mutual interactions and, metabolism within the body are a challenge to research. Moreover, the kidney is especially prone to injury owing to its physiology.
Nadezda Petejova, Arnost Martinek, Josef Zadrazil, Vladimir Teplan   +3 more
openaire   +3 more sources

Assessment of acute kidney injury risk using a machine-learning guided generalized structural equation model: a cohort study

BMC Nephrology, 2021
Background Acute kidney injury is common in the surgical intensive care unit (ICU). It is associated with poor patient outcomes and high healthcare resource usage. This study’s primary objective is to help identify which ICU patients are at high risk for
Wen En Joseph Wong, Siew Pang Chan, Juin Keith Yong, Yen Yu Sherlyn Tham, Jie Rui Gerald Lim, Ming Ann Sim, Chai Rick Soh, Lian Kah Ti, Tsong Huey Sophia Chew   +8 more
doaj   +1 more source

Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury

Nature Communications, 2021
Acute kidney injury (AKI) is morphologically characterized by a synchronized plasma membrane rupture of cells in a specific section of a nephron, referred to as acute tubular necrosis (ATN).
W. Tonnus, C. Meyer, C. Steinebach, A. Belavgeni, Anne von Mässenhausen, Nadia Zamora Gonzalez, F. Maremonti, F. Gembardt, N. Himmerkus, Markus Latk, S. Locke, J. Marschner, Wenjun Li, S. Short, S. Doll, Irina Ingold, B. Proneth, C. Daniel, Nazanin Kabgani, R. Kramann, Stephen E. Motika, P. Hergenrother, S. Bornstein, C. Hugo, J. Becker, K. Amann, H. Anders, D. Kreisel, D. Pratt, M. Gütschow, M. Conrad, A. Linkermann   +31 more
semanticscholar   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Heart failure subtype after acute kidney injury

BMC Nephrology
Introduction Acute kidney injury (AKI) is associated with increased risk of heart failure (HF). Determining the type of HF experienced by AKI survivors (heart failure with preserved or reduced ejection fraction, HFpEF or HFrEF) could suggest potential ...
Bethany C. Birkelo, Evan Brittain, Andrew Guide, Robert A. Greevy, Michael E. Matheny, Jeffrey Annis, Trey Richardson, Sarah Faubel, Edward D. Siew   +8 more
doaj   +1 more source

Impact of acute kidney injury on major adverse cardiovascular events in intensive care survivors

BJA Open, 2023
Background: Acute kidney injury commonly occurs in patients admitted to ICU. After acute kidney injury, kidney function may not completely recover leading to increased risk of future cardiovascular events.
Mark Andonovic, Jennifer Curle, Jamie P. Traynor, Martin Shaw, Malcolm A.B. Sim, Patrick B. Mark, Kathryn A. Puxty   +6 more
doaj   +1 more source