Results 101 to 110 of about 644,663 (282)
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
IJU Case Reports, 2020 Introduction Simultaneous liver and kidney transplantation is a life‐saving procedure for patients with liver failure and irreversible renal dysfunction.
Kodai Hattahara +9 more
doaj +1 more source
New technologies - new insights into the pathogenesis of hepatic encephalopathy [PDF]
, 2016 Hepatic encephalopathy (HE) is a neuropsychiatric syndrome which frequently accompanies acute or chronic liver disease. It is characterized by a variety of symptoms of different severity such as cognitive deficits and impaired motor functions. Currently,
Ampuero, J +6 more
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Galectin-9 as a new biomarker of acute-on-chronic liver failure
Scientific ReportsGalectin-9 (Gal-9) expression in patients with acute-on-chronic liver failure and its correlation with prognosis remain unclear. This study investigated the relationship between liver failure prognosis and Gal-9 expression analysis in patients with acute-
Jun Ling +5 more
doaj +1 more source
Auxiliary Liver Transplantation as a Transient Treatment for Acute Liver Failure: Two Cases
GE: Portuguese Journal of Gastroenterology, 2018 Introduction: Acute liver failure is an uncommon condition associated with a high mortality. Most patients do not survive without liver transplantation. In the last decades, auxiliary liver transplantation has emerged as a therapeutic option.
David N. Perdigoto +7 more
doaj +1 more source
The clinical significance of the arterial ketone body ratio as an early indicator of graft viabilityin human liver transplantation [PDF]
, 1991 Arterial ketone body ratio (AKBR) was measured sequentially in 84 liver transplantations (OLTx). These transplantation procedures were classified into 3 groups with respect to graft survival and patient condition at the end of the first month (Group A ...
Asonuma, K +8 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Pediatric liver failure: we came, we saw, but have we conquered? [version 1; referees: 2 approved]
F1000Research, 2017 Although there have been advances made in the diagnosis and management of pediatric acute liver failure, there is still no consensus regarding the definition or standardized evaluation, and an inability to predict outcomes, specifically irreversible ...
Sara Kathryn Smith, Philip Rosenthal
doaj +1 more source
Matrix metalloproteinases in liver injury, repair and fibrosis. [PDF]
, 2015 The liver is a large highly vascularized organ with a central function in metabolic homeostasis, detoxification, and immunity. Due to its roles, the liver is frequently exposed to various insults which can cause cell death and hepatic dysfunction ...
Baber, John +3 more
core +1 more source