Results 111 to 120 of about 386,804 (284)

Pediatric liver failure: we came, we saw, but have we conquered? [version 1; referees: 2 approved]

F1000Research, 2017
Although there have been advances made in the diagnosis and management of pediatric acute liver failure, there is still no consensus regarding the definition or standardized evaluation, and an inability to predict outcomes, specifically irreversible ...
Sara Kathryn Smith, Philip Rosenthal
doaj   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Acute Liver Failure: A Dangerous and Challenging Syndrome

, 2014
Despite progress in understanding the underlying mechanisms, acute liver failure (ALF) is still one of the major clinical challenges in hepatology. A wide variety of aetiologies, and similarly, variable courses of the disease, make it crucial to identify
Guido Gerken, Ali Canbay
core  

Acute liver failure as initial presentation in a Chinese patient with Budd-Chiari syndrome due to protein C deficiency: A case report and literature review

Heliyon
Acute liver failure is an uncommon presentation in the clinic. Common causes for acute liver failure include viral hepatitis and drug-related hepatotoxicity. However, acute liver failure due to Budd-Chiari syndrome is rare.
Wanling Xu, Wenjing Tang, Weiying Yang, Lichao Sun, Wei Li, Shouqing Wang, Xiuxian Zang   +6 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Levels of von Willebrand factor antigen and von Willebrand factor cleaving protease (ADAMTS13) activity predict clinical events in chronic heart failure.

, 2009
Decreased activity of ADAMTS13, the von Willebrand factor (VWF) cleaving protease, was recently reported in cardiovascular diseases and in hepatic failure.
Borgulya, Gábor, Hársfalvi, Jolán, Gombos, Tímea, Cervenak, László, Jánoskuti, Lívia, Förhécz, Zsolt, Prohászka, Zoltán, Papassotiriou, Jana, Makó, Veronika, Pozsonyi, Zoltán, Kunde, Jan   +10 more
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

A novel microRNA-based prognostic model outperforms standard prognostic models in patients with acetaminophen-induced acute liver failure.

, 2021
BACKGROUND & AIMS: Acetaminophen (APAP)-induced acute liver failure (ALF) remains the most common cause of ALF in the Western world. Conventional prognostic models, utilising markers of liver injury and organ failure, lack sensitivity for mortality ...
Agarwal, Kosh, United States Acute Liver Failure Study Group,, Tavabie, Oliver D, Prachalias, Andreas, Heneghan, Michael A, Lee, William M, Fix (United States Acute Liver Failure Study Group), Oren K, Aluvihare, Varuna R, McPhail, Mark J W, Rose, Christopher F, Menon, Krishna, Speiser, Jaime L, Salehi, Siamak, Karvellas, Constantine J   +13 more
core  

Peripheral infusion of human umbilical cord mesenchymal stem cells rescues acute liver failure lethality in monkeys

Stem Cell Research & Therapy, 2019
Background Acute liver failure (ALF) is a complicated clinical syndrome associated with high mortality, with liver transplantation as the only treatment option.
Gang Guo, Xiang Zhuang, Qing Xu, Zhenru Wu, Yongjie Zhu, Yongjie Zhou, Yuanmin Li, Yanrong Lu, Bo Zhang, Prue Talbot, Jiayu Liao, Junjun She, Hong Bu, Yujun Shi   +13 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source