Results 191 to 200 of about 1,516,904 (247)

Philadelphia chromosome-positive acute lymphoblastic leukaemia in children and adolescents: A changing treatment landscape and a methodological challenge. [PDF]

Br J Haematol
Balduzzi A, Valsecchi MG, Tran TH, Zuna J, Leoni V, Cario G, Fazio G, Gandemer V, Tasian SK, van der Sluis IM, Peccatori N, Parasole R, Monterisi S, Loh ML, Devidas M, Hunger SP, Kairalla JA, De Lorenzo P, Silverman LB, Biondi A.   +19 more
europepmc   +1 more source

Pharmacokinetic profiling of imatinib in relation to CYP3A4 activity in leukaemia patients

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3375-3386, October 2026.
Aim Imatinib pharmacokinetics exhibit large interindividual variability because of differences in CYP3A4 activity—the main imatinib‐metabolizing enzyme. While therapeutic drug monitoring is effective, it requires steady‐state conditions and frequent sampling.
Anna Sofie Buhl Rasmussen, Mathilde Rønne Koch, Cecilie Utke Rank, Christen Lykkegaard Andersen, Allan Weimann, Maria Thastrup, Tianwu Yang, Trine Meldgaard Lund, Ib Jarle Christensen, Flemming Nielsen, Tore Bjerregaard Stage, Sara Bisgaard Jensen, Mette Klarskov Andersen, Kjeld Schmiegelow, Kim Dalhoff   +14 more
wiley   +1 more source

High-Resolution NGS HLA Typing Identifies Specific Class II-Dominant Risk Haplotypes and HLA LD Structure in Acute Lymphoblastic Leukaemia Among Ethnic Kazakhs. [PDF]

HLA
Burkitbayev Z, Turganbekova A, Zhanzakova Z, Baimukasheva D, Saduakas Z, Khamitova D, Abdrakhmanova S, Masalimov Z, Almawi WY.   +8 more
europepmc   +1 more source

Clinicopathological Features and Exploratory Outcome Associations of Bone Marrow Fibrosis in Newly Diagnosed Acute Lymphoblastic Leukemia: A Single‐Center Retrospective Cohort Study

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Bone marrow fibrosis (MF) reflects stromal remodeling and has been associated with treatment resistance and adverse outcomes in hematologic malignancies; however, its clinical significance in acute lymphoblastic leukemia (ALL) remains uncertain.
Ying Chen, Si‐Heng Liu, Cen‐Xia Ran, Wu‐Chen Yang, Jia Li, Xian‐Gui Peng, Lei Gao, Li Gao, Yi‐Mei Feng, Qin Wen, Jun Rao, Pei‐Yan Kong, Xi Zhang, Cheng Zhang   +13 more
wiley   +1 more source

Invasive yeast infection in paediatric acute lymphoblastic leukaemia: A report from the multi-international clinical trial AIEOP-BFM ALL 2009. [PDF]

Br J Haematol
Groll AH, Cesaro S, Alten J, Attarbaschi A, Barbaric D, Ebrahimi-Fakhari D, Bodmer N, Conter V, Elitzur S, Möricke A, Schrappe M, Stary J, Zapotocka E, Zimmermann M, Lehrnbecher T.   +14 more
europepmc   +1 more source

AMPK‐Mediated Lipid Metabolic Reprogramming in Cancer: From Mechanisms to Targeted Therapies

Cell Biochemistry and Function, Volume 44, Issue 10, October 2026.
ABSTRACT AMP‐activated protein kinase (AMPK), a key regulator of cellular energy metabolism, is activated under conditions of energy stress to restore metabolic homeostasis by promoting catabolic pathways and inhibiting anabolic processes such as lipid synthesis. Multiple key molecules involved in lipid metabolism are regulated by AMPK, and its role in
Yuying Chen, Wen Liu, Bing Luo
wiley   +1 more source

B-Cell Acute Lymphoblastic Leukaemia Presenting With Bilateral Renal Enlargement. [PDF]

Cureus
Soruna O, Qureshi M, Prabha M, Bartram J, Tsouana E.   +4 more
europepmc   +1 more source

Potential Benefit of Ruxolitinib in Suspected Ocular and Neurological Transplant‐Associated Thrombotic Microangiopathy After Allogeneic Stem Cell Transplantation: A Case Report and Review

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT We describe a rare case of suspected delayed‐onset TA‐TMA with ocular and neurological involvement following allo‐HSCT. The condition was refractory to standard therapies; neurological improvement was temporally associated with ruxolitinib initiation, suggesting a possible GVHD overlap.
Lise‐Marie Pillet, Antoine Arandilla, Gaëtan Sauvetre, Paul Goupillou, Adrien Lefevre, Maximilien Grall, Antoine Bonnevalle, Bertrand Bourre, Dominique Penther, Sophie Porcheron, Fabrice Jardin, Mustafa Alani, Sydney Dubois, Vincent Camus   +13 more
wiley   +1 more source

Immunophenotypic Profiling of Lymphocyte Subsets in Children and Adolescents With Acute Lymphoblastic Leukaemia: Immune Dysregulation Before and After Remission. [PDF]

J Immunol Res
Nafady-Hego H, Flemban A, Kabrah S, Abd Elmoneim HM, Aly E, Elgendy M, Albukhari T, Elgendy H, Alaa H, Almaghrabi R, Ekram SN, Nafady A.   +11 more
europepmc   +1 more source

Outcomes of adult patients with Li‐Fraumeni syndrome and myeloid neoplasms

Cancer, Volume 132, Issue 19, 1 October 2026.
Abstract Background Li‐Fraumeni syndrome (LFS) is an inherited cancer predisposition syndrome. Hematologic malignancies are not considered LFS defining tumors, however, both acute lymphoblastic leukemia and therapy‐related myeloid neoplasms (MNs) in LFS are described. Treatment approaches and outcomes of MN in LFS need further evaluation.
Jayastu Senapati, Hiam M. Abdel‐Salam, Vladislav D. Jdanov, Sanam Loghavi, Ashley Woodson, Jessica Corredor, Gautam Borthakur, Naval G. Daver, Tapan M. Kadia, Koichi Takahashi, Yesid Alvarado, Naveen Pemmaraju, Uday R. Popat, Elizabeth J. Shpall, Farhad Ravandi, Florencia McAllister, Najat C. Daw, Guillermo Garcia‐Manero, Banu K. Arun, Courtney D. DiNardo   +19 more
wiley   +1 more source