Results 71 to 80 of about 1,516,904 (247)

CRISPR Genome Editing and the Future of Leukaemia Immunotherapy

Health Science Reports
Background and Aims Leukaemia presents ongoing therapeutic challenges due to relapse and toxicity associated with standard treatments. By enabling more targeted and safer therapies, CRISPR genome editing is emerging as a powerful tool to address these ...
Dejin Rai, Umberto Terranova
doaj   +1 more source

KMT2A-rearranged acute lymphoblastic leukaemia

EJC Paediatric Oncology
KMT2A-rearranged acute lymphoblastic leukaemia (ALL) represents a high risk subtype of childhood ALL. Historical treatment strategies have comprised of intensification with conventional chemotherapy.
Rishi S. Kotecha, Rob Pieters, Janine Stutterheim   +2 more
doaj   +1 more source

Measurable Residual Disease in Acute Leukaemias: A Narrative Review on Specimen Adequacy, Assay Selection, Interpretive Pitfalls and Challenges for the Practicing Pathologist [PDF]

Journal of Clinical and Diagnostic Research
Measurable Residual Disease (MRD) is a key prognostic marker in acute leukaemias, guiding therapy and risk stratification. Even in morphologic remission, residual clones drive relapse, highlighting the need for sensitive, standardised detection.
Sneha Sukumar, Samarth Shukla, Sunita Vagha, Shailly Tiwari   +3 more
doaj   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Chronotype and sleep duration in relation to leukaemia subtypes: a two-sample Mendelian randomization analysis

Hematology
Objectives Several observational studies have suggested an association between sleep traits and leukaemia. This study aimed to determine the causal association between sleep traits and leukaemia using two-sample Mendelian Randomization (MR) analysis ...
Lina Wang, Jiang Liu, Jiahui Liu, Ling Zhang, Ruijuan Zhang   +4 more
doaj   +1 more source

Papilledema in a child with Acute Lymphoblastic Leukaemia during remission-A Case Report

BLDE University Journal of Health Sciences, 2020
Background: Ocular manifestations of pediatric ALL may be the presenting sign of the disease or may signify leukemic recurrence. Objective: To report papilledema in a diagnosed case of Acute Lymphoblastic Leukaemia during remission.
C Vivek Nandini Reddy, M H Patil
doaj   +1 more source

Patient‐reported outcomes and medication errors during oral antitumour therapy in paediatrics: Results from the youngAMBORA care programme

British Journal of Clinical Pharmacology, EarlyView.
Aim Increasing use of oral antitumour therapeutics (OAT) in paediatrics is associated with numerous advantages, but also with error‐prone aspects. Based on the randomized AMBORA trial including adults treated with various OAT, we developed a tailored pharmacological/pharmaceutical care programme for children and their caregivers during OAT treatment ...
Phyllis Lensker, Lisa Cuba, Frank Dörje, Martin F. Fromm, Markus Metzler   +4 more
wiley   +1 more source

Hyperoeosinophilia at diagnosis in adolescent acute lymphoblastic leukaemia/lymphoma: A case report and review of the literature

Advances in Human Biology, 2020
Acute lymphoblastic leukaemia (ALL) or lymphoblastic lymphoma (LBL) presenting as peripheral blood hyperoeosinophilia is a sporadic disorder with fewer than fifty cases described since 1973, and the cumulative incidence is
Dilshad Jahan, Mainul Haque
doaj   +1 more source

Clinical Functional Assignment of TPMT and NUDT15 Alleles by the Clinical Pharmacogenetics Implementation Consortium Pharmacogene Curation Expert Panel

Clinical Pharmacology &Therapeutics, EarlyView.
The Clinical Pharmacogenetics Implementation Consortium (CPIC) TPMT/NUDT15 Pharmacogene Curation Expert Panel (PCEP) conducted a comprehensive review of clinical, laboratory, and computational evidence to determine the clinical function assignments for TPMT and NUDT15 star alleles.
Bailey M. Tibben, Maud Maillard, Victoria M. Pratt, Ann M. Moyer, Debbie M. Figueroa, Michelle Whirl‐Carrillo, Andrea Gaedigk, Gabriele Stocco, Matthias Schwab, Kelly E. Caudle, Jun J. Yang   +10 more
wiley   +1 more source

Flow cytometry‐based monitoring of chimeric antigen receptor (CAR) T cells: Reagent selection, assay design, and clinical utility

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate quantification of chimeric antigen receptor (CAR) T cells is essential for monitoring post‐infusion CART expansion and persistence and for real‐time clinical decision‐making. Multiparameter flow cytometry (MFC) enables rapid, live‐cell detection with absolute quantification and concurrent immunophenotypic characterization. This review
Jianhua Ling, Wei Wang, Sa A. Wang
wiley   +1 more source