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Mesenchymal stem cells-derived TGF-β1 promotes polarization of M2 macrophages in mice with acute-on-chronic liver failure via FOSL1/MERTK axis. [PDF]

Stem Cell Res Ther
Chen JF, Li ZH, Zhang J, Meng SB, Wang JL, Lei ZY, Wang JY, Wu LL, Zheng Y, Gao ZL, Lin BL.   +10 more
europepmc   +1 more source

Novel Diagnostic Marker Interleukin-33 for Invasive Pulmonary Aspergillosis in Acute-on-Chronic Liver Failure: A Proof-of-Concept Prospective Study. [PDF]

Infect Dis Ther
Huang L, Zhang M, Liu W, Liu Y, Chen L, Niu Y, Feng Y, Cheng Q, Liu T, Wang P, Song M, Chen G, Zhu L, Chen T, Ning Q.   +14 more
europepmc   +1 more source

Acute-on-Chronic Liver Failure [PDF]

New England Journal of Medicine, 2020
Acute-on-chronic liver failure (ACLF) is a recently recognised and defined syndrome seen in patients with liver cirrhosis and carries a high short-term mortality in excess of 15% at 28 days. ACLF is defined by organ failures (OFs) and is distinct from simple 'acute decompensation' (AD) of cirrhosis.
Vicente Arroyo, Richard Moreau, Rajiv Jalan   +2 more
exaly   +13 more sources

Acute-on-chronic liver failure [PDF]

Lancet, The, 2015
Acute-on-chronic liver failure combines an acute deterioration in liver function in an individual with pre-existing chronic liver disease and hepatic and extrahepatic organ failures, and is associated with substantial short-term mortality. Common precipitants include bacterial and viral infections, alcoholic hepatitis, and surgery, but in more than 40%
William Bernal, Rajiv Jalan, Alberto Quaglia   +2 more
exaly   +6 more sources

Acute-on chronic liver failure

Journal of Hepatology, 2012
Acute-on-chronic liver failure (ACLF) is an increasingly recognised entity encompassing an acute deterioration of liver function in patients with cirrhosis, which is usually associated with a precipitating event and results in the failure of one or more organs and high short term mortality.
Rajiv Jalan, Pere Ginès, Jody C Olson
exaly   +3 more sources

Liver transplantation for acute-on-chronic liver failure [PDF]

Hepatology International, 2009
To evaluate the outcome of liver transplantation for acute-on-chronic liver failure.From November 1991 to December 2007, 517 patients underwent liver transplantation at Queen Mary Hospital, Hong Kong. Among them, 149 had acute-on-chronic liver failure as defined in the recent Asian Pacific Association for the Study of Liver Consensus Meeting.
See Ching Chan, K K C Ng
exaly   +5 more sources

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Pediatric Acute-on-Chronic Liver Failure

Indian Journal of Pediatrics, 2023
Acute-on-chronic liver failure (ACLF) is characterized by an acute hepatic insult happening in a patient with underlying cirrhosis with compromised hepatic reserve leading to development of systemic inflammation, sepsis, and organ failure resulting in poor outcome in majority.
Seema Alam, Bikrant Bihari Lal
openaire   +2 more sources

Acute-on-chronic Liver Failure

Current Gastroenterology Reports, 2016
Acute-on-chronic liver failure (ACLF) is a distinct entity that differs from acute liver failure and decompensated cirrhosis in timing, presence of treatable acute precipitant, and course of disease, with a potential for self-recovery. The core concept is acute deterioration of existing liver function in a patient of chronic liver disease with or ...
Shiv Kumar, Sarin, Ashok, Choudhury
openaire   +2 more sources

Liver Transplantation in Acute-on-Chronic Liver Failure

Clinics in Liver Disease, 2023
In recent years there has been a significant increase in the incidence of acute-on-chronic liver failure (ACLF). This syndrome is characterized by infections, organ failures, and high short-term mortality. Although progress in the management of these sick patients has been evident, liver transplantation (LT) remains the best treatment modality to date.
Anand V, Kulkarni, K Rajender, Reddy
openaire   +2 more sources