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Liver Regeneration in Acute on Chronic Liver Failure
Clinics in Liver Disease, 2023Liver regeneration is a multifaceted process by which the organ regains its original size and histologic organization. In recent decades, substantial advances have been made in our understanding of the mechanisms underlying regeneration following loss of hepatic mass.
Madelyn J, Blake, Clifford J, Steer
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Acute on chronic liver failure
Gastroenterología y Hepatología, 2010Acute-on-Chronic Liver Failure (ACLF) is a recently introduced term defined as severe acute deterioration of an established liver disease. This entity usually develops after an acute insult. The main clinical manifestations are hepatorenal syndrome, hepatic encephalopathy and organ failure, with a high risk of death in the short term.
Angels, Escorsell Mañosa +1 more
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Liver Transplantation in Acute-on-chronic Liver Failure
Transplantation, 2020Liver transplantation (LT) has revolutionized outcomes for cirrhotic patients. Current liver allocation policies dictate patients with highest short-term mortality receive the highest priority, thus, several patients become increasingly ill on the waitlist.
Constantine J, Karvellas +2 more
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Pro: Acute‐on‐chronic liver failure
Liver Transplantation, 2017Liver Transplantation 23 1318–1324 2017 AASLD.
Solà, Elsa, Ginès, Pere
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Update on acute-on-chronic liver failure
Gastroenterología y Hepatología (English Edition), 2018Acute-on-chronic liver failure (ACLF) is a recently defined syndrome characterised by acute decompensation of chronic liver disease, associated with organ failures and high mortality. ACLF is a common condition and may affect up to 30% of patients admitted to hospital for cirrhosis complications.
Cristina, Solé, Elsa, Solà
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Overview on acute-on-chronic liver failure
Frontiers of Medicine, 2016Liver failure (LF) is defined as severe dysfunction in hepatic synthesis, detoxification, and metabolism induced by various etiologies. Clinical presentation of LF typically includes severe jaundice, coagulation disorder, hepatic encephalopathy, and ascites. LF can be classified into acute LF, acute-on-chronic LF (ACLF), and chronic LF.
Jing, Zhang +3 more
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Chronic Liver Failure and Acute-on-Chronic Liver Failure
2020Chronic liver failure (CLF) is the result of persistent liver damage. Given the multifaceted abilities of the organ, CLF is a multisystem progressive disease that evolves from an asymptomatic (compensated) to a clinically manifested phase (decompensated) driven by hemodynamic disturbances and systemic inflammation.
Rita Garcia-Martinez +3 more
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Acute-on-Chronic Liver Failure
2021In the last two decades, a new concept of acute-on-chronic liver failure (ALCF) has emerged as a distinctive condition compared to decompensated cirrhosis. ACLF is associated with excessive systemic inflammatory response in patients with underlying chronic liver disease, leading to acute deterioration of liver function, multi-organ failure, as well as ...
Marie-Eve Chartier, Fernando Alvarez
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Acute on Chronic Liver Failure
2019Acute on chronic liver failure (ACLF) describes a clinical syndrome characterized by (1) a patient with chronic liver disease that develops a (2) new or worsening hepatic decompensation with (3) marked dysfunction of other extrahepatic organs and (4) an increased short-term mortality.
Mark R. Pedersen, Shannan R. Tujios
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Acute-on-Chronic Liver Failure
American Journal of Gastroenterology, 2022Jasmohan S, Bajaj +4 more
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