Results 51 to 60 of about 1,012,363 (342)

The meaning of different forms of structural myocardial injury, immune response and timing of infarct necrosis and cardiac repair [PDF]

, 2015
Although a decline in the all-cause and cardiac mortality rates following myocardial infarction (MI) during the past 3 decades has been reported, MI is a major cause of death and disability worldwide.
Bello, S, Fineschi, Vittorio, Neri, M, Pomara, C, Riezzo, I, Turillazzi, E   +5 more
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

The histopathological spectrum of acute generalized exanthematous pustulosis (AGEP) and its differentiation from generalized pustular psoriasis [PDF]

, 2010
Background: Acute generalized exanthematous pustulosis (AGEP) represents a severe, acute, pustular skin reaction that is most often induced by drugs. AGEP can be difficult to differentiate from generalized pustular psoriasis (GPP) both clinically and ...
Austin, Baker, Beylot, Beylot, Britschgi, Burrows, Farber, Friedman, Guevara-Gutierrez, Horn, Iizuka, Kardaun, Katz, Keller, Kingery, Macmillan, Mobini, Muller, Naldi, Roujeau, Roujeau, Schaefer, Schmid, Shelley, Shelley, Sidoroff, Sidoroff, Smith, Spencer, Staughton, Terui, Weedon, Weedon, Yawalkar, Zelickson   +34 more
core   +6 more sources

Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3 [PDF]

, 2004
INTRODUCTION: Involution of the mammary gland is a complex process of controlled apoptosis and tissue remodelling. The aim of the project was to identify genes that are specifically involved in this process.
Bell, A.K., Davies, C.R., Duffy, M.A., Ferrier, R.K., Gusterson, B.A., Heath, V.J., Morris, J.S., Sandilands, G.P., Stein, T., Weber-Hall, S.J.   +9 more
core  

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Early Diagnostic Prediction of Covid-19 using Gradient-Boosting Machine Model [PDF]

arXiv, 2021
With the huge spike in the COVID-19 cases across the globe and reverse transcriptase-polymerase chain reaction (RT-PCR) test remains a key component for rapid and accurate detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In recent months there has been an acute shortage of medical supplies in developing countries, especially a
arxiv  

Expression of factor V by resident macrophages boosts host defense in the peritoneal cavity [PDF]

, 2019
Macrophages resident in different organs express distinct genes, but understanding how this diversity fits into tissue-specific features is limited. Here, we show that selective expression of coagulation factor V (FV) by resident peritoneal macrophages ...
Broze, George J, Cleuren, Audrey C, Czepielewski, Rafael S, Edelson, Brian T, Erlich, Emma C, Esaulova, Ekaterina, Grover, Steven P, Jarjour, Nicholas N, Mackman, Nigel, Randolph, Gwendalyn J, Saunders, Brian T, Zhang, Nan, Zinselmeyer, Bernd H   +12 more
core   +1 more source

Bedside differentiation of vestibular neuritis from central "vestibular pseudoneuritis". [PDF]

, 2008
Acute unilateral peripheral and central vestibular lesions can cause similar signs and symptoms, but they require different diagnostics and management.
Brandt, Thomas, Cnyrim, C. D., Karch, C., Newman-Toker, D., Strupp, Michael   +4 more
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source