Results 61 to 70 of about 7,156,078 (242)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Acute-phase diagnosis of murine and scrub typhus in Belgian travelers by polymerase chain reaction: a case report

BMC Infectious Diseases, 2017
Background Rickettsiosis is a potential life threatening infectious disease in travelers. Clinical recognition is not always straightforward, as typical manifestations such as rash and/or eschar may be absent.
Caroline Theunissen, Lieselotte Cnops, Marjan Van Esbroeck, Ralph Huits, Emmanuel Bottieau   +4 more
doaj   +1 more source

Rigorous Multicomponent Reactive Separations Modelling : Complete Consideration of Reaction-Diffusion Phenomena [PDF]

, 2010
This paper gives the first step of the development of a rigorous multicomponent reactive separation model. Such a model is highly essential to further the optimization of acid gases removal plants (CO2 capture, gas treating, etc.) in terms of size and ...
Ahmadi, Aras, Alix, P., Laloue, N., A. Ahmadi, Laloue, Nicolas, Meyer, Michel, M. Meyer, Alix, Pascal, P. Alix, Prevost, Michel, Ahmadi, A., Prevost M., Ahmadi A., Rouzineau D., M. Prevost, Laloue N., Rouzineau, David, N. Laloue, Alix P., D. Rouzineau, Meyer M.   +20 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Transcriptome Analysis of Acute Phase Liver Graft Injury in Liver Transplantation

Biomedicines, 2018
Background: Liver transplantation remains the treatment of choice for a selected group of hepatocellular carcinoma (HCC) patients. However, the long-term benefit is greatly hampered by post-transplant HCC recurrence.
Nikki P. Lee, Haiyang Wu, Kevin T.P. Ng, Ruibang Luo, Tak-Wah Lam, Chung-Mau Lo, Kwan Man   +6 more
doaj   +1 more source

Reaction time and intelligence:Comparing associations based on two response modes [PDF]

, 2013
People who score highly on intelligence tests also tend to have faster and less variable reaction times. Effect size estimates for the reaction time-intelligence association are larger in samples that are more representative of the population.
Deary, Ian J., Liewald, David, Nissan, Jack   +2 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Optimal combinations of acute phase proteins for detecting infectious disease in pigs [PDF]

, 2011
Peer ...
Mathilda JM Toussaint, Eckersall, P.D., Anders Stockmarr, Campbell, Fiona M, Rakel Carpintero, Piñeiro, M., Toussaint, Mathilda J.M., Sorensen, N., Eckersall, P. David, Campbell, F.M., Nanna Sorensen, Campbell, Fiona Margaret, Toussaint, M.J.M., Carpintero, Rakel, Fiona M Campbell, Lampreave, F., Skall Sorensen, Nanna, P Eckersall, Carpintero, R., Erik Gruys, Piñeiro, Matilde, Heegaard, P.M.H., Fermin Lampreave, Stockmarr, A., Toussaint, Mathilda JM, Lampreave, Fermin, Sørensen, Nanna Skall, Matilde Piñeiro, Heegaard, Peter M. H., Peter MH Heegaard, Gruys, Erik, Gruys, E., Eckersall, P David, Stockmarr, Anders, Lampreave Fermin, Eckersall P, Stockmarr Anders, Sorensen Nanna, Gruys Erik, Carpintero Rakel, Heegaard Peter MH, Campbell Fiona M, Piñeiro Matilde, Toussaint Mathilda JM   +43 more
core   +1 more source