Results 91 to 100 of about 264,861 (313)

The helicase HAGE prevents interferon-a-induced PML expression in ABCB5+ malignant melanoma-initiating cells by promoting the expression of SOCS1 [PDF]

, 2014
The tumour suppressor PML (promyelocytic leukaemia protein) regulates several cellular pathways involving cell growth, apoptosis, differentiation and senescence.
A Carracedo, A Hauschild, A Jankowsky, A Kakizuka, AA Tarhini, AJ Linley, BJ Wilson, C Gurrieri, C Lavau, C Schindler, D Ungureanu, DJ Groskreutz, G Marie-Claude, GB Lesinski, H de The, J Borrow, K Ito, K Wheatley, M Stadler, MK Chelbi-Alix, NY Frank, O Cordin, P Salomoni, RAR Piganis, S Aaronson, T Kamura, T Regad, T Regad, T Regad, T Schatton, TA Endo, W Condemine, WB Dias, Z Li   +33 more
core   +1 more source

Down syndrome with microgranular variant of acute promyelocytic leukemia in a child: a case report

Journal of Medical Case Reports, 2007
Background Acute promyelocytic leukemia (APL) accounts for less than 10% of pediatric AML. Cases of APL in Down syndrome (DS) have been described in the literature rarely and it is rarer still to find the microgranular variant (M3v) of APL in trisomy 21 ...
Jain Deepali, Singh Tejinder, Arora Prerna   +2 more
doaj   +1 more source

Case report: A rare case of TBL1XR1-RARB positive acute promyelocytic leukemia in child and review of the literature

Frontiers in Oncology, 2022
Some forms of acute myelogenous leukemia (AML) share typical morphological and immunophenotypic features of acute promyelocytic leukemia (APL) but are negative for promyelocytic leukemia-retinoic acid receptor alpha (PML-RARA) fusion.
Mingyan Jiang, Mingyan Jiang, Jinrong Li, Jinrong Li, Jianrong Wu, Jianrong Wu, Yiping Zhu, Yiping Zhu, Ju Gao, Ju Gao   +9 more
doaj   +1 more source

Microwave‐Assisted Organic Syntheses in Deep Eutectic Solvents: A Win‐Win Association for Sustainable Chemistry

ChemistryOpen, EarlyView.
In organic synthesis, deep eutectic solvents (DES) have demonstrated their ability to be used as reaction media for the development of reactions in line with green chemistry principles. This review presents an overview of microwave‐assisted organic synthesis in DES, highlighting the diversity of uses for these solvents, their role in mechanisms, the ...
Pierre‐Olivier Delaye, Chefikou Salami, Emilie Thiery   +2 more
wiley   +1 more source

Differentiation syndrome in patients with acute promyelocytic leukemia treated with all- trans retinoic acid and anthracycline chemotherapy: Characteristics, outcome, and prognostic factors [PDF]

, 2009
Differentiation syndrome (DS) can be a life-threatening complication in patients with acute promyelocytic leukemia (APL) undergoing induction therapy with all- trans retinoic acid (ATRA). Detailed knowl- edge about DS has remained limited.
Adès, Angel León, Avvisati, Bennett, Bennett, Bob Lowenberg, Chelo Rayón, Cheson, Concha Rivas, Cortes, Cox, Cox, Cunha De Santis, De Botton, De Botton, De la Serna, Di Noto, Dixon, Edo Vellenga, Elena Amutio, Falanga, Fenaux, Frankel, Guillermo Debén, Gustavo Milone, Javier de la Serna, Joaquín Díaz-Mediavilla, Jordi Esteve, Jose D. González, Juan M. Bergua, Kanamaru, Kaplan, Ko, Larson, Lee, Lengfelder, Mandelli, Mar Tormo, Marcos González, Miguel A. Sanz, Pau Montesinos, Ricardo Parody, Salut Brunet, Sanz, Sanz, Sanz, Sanz, Silvia Negri, Tallman, Tallman, Vahdat, Wiley, Wu, Yanada   +53 more
core   +4 more sources

Advances in Elemene Nanodelivery Systems: From Material Design to Disease Treatment

Rare Metals, EarlyView.
ABSTRACT Elemene (ELE) is a bioactive sesquiterpenoid extracted from traditional Chinese herbs, demonstrating broad‐spectrum antitumor, anti‐inflammatory, and analgesic properties with significant therapeutic potential. However, its clinical utility is constrained by inherent physicochemical limitations, including volatility and hydrophobicity, which ...
Xiao Wang, Jiatong Lin, Yi Peng, Zehua Wu, Yingying Liu, Wei Duan, Qiaolin Wei, Jia‐Wei Shen, Jiang‐Xing Chen, Yong Guo   +9 more
wiley   +1 more source

Survival and treatment response in adults with acute promyelocytic leukemia treated with a modified International Consortium on Acute Promyelocytic Leukemia protocol

Revista Brasileira de Hematologia e Hemoterapia
Acute promyelocytic leukemia has good prognosis in view of the high complete remission and survival rates achieved with therapies containing all-trans retinoic acid or arsenic trioxide.
Erick Crespo-Solis, Jorge Contreras-Cisneros, Roberta Demichelis-Gómez, Adriana Rosas-López, Juan Mauricio Vera-Zertuche, Alvaro Aguayo, Xavier López-Karpovitch   +6 more
doaj   +1 more source

Treatment of Acute Promyelocytic Leukemia in Adults.

Journal of Oncology Practice, 2018
The treatment of acute promyelocytic leukemia (APL) has evolved rapidly in the past two decades after the introduction of highly active drugs, including tretinoin (all- trans-retinoic acid) and arsenic trioxide.
A. Osman, Jennifer L. Anderson, J. Churpek, Trevor Christ, E. Curran, L. Godley, Hongtao Liu, M. Thirman, T. Odenike, W. Stock, R. Larson   +10 more
semanticscholar   +1 more source

Attenuation of arsenic trioxide‐induced endothelial injury: unveiling the protective role of ginkgolic acid through inhibition of TRPM4 SUMOylation: Evidence from Raman cellular imaging

VIEW, EarlyView.
Inhibiting the SUMOylation modification of TRPM4 can prevent the vascular endothelial damage caused by ATO. Inhibition of TRPM4 SUMOylation, either pharmacologically by GA or genetically by the K618R mutation, protects against ATO‐induced vascular endothelial damage.
Ting‐Ting Tong, Ya‐Dong Xue, Yu‐Yao Zhang, Chun‐Xiao Yu, Xin‐Yu Yao, Yu‐Xuan Han, Kai Zhang, Mei‐Mei Shen, Yu Zhao, Yun‐Feng Cui, Zi‐Yue Ma, Yu‐Yang Fu, Yong‐Zhen Wang, Jing Jin, Ke Tang, Yang Liu, Yang Li, Rong Huo, Tao Ban   +18 more
wiley   +1 more source

Adenovirus type 5 E4 Orf3 protein targets promyelocytic leukaemia (PML) protein nuclear domains for disruption via a sequence in PML isoform II that is predicted as a protein interaction site by bioinformatic analysis [PDF]

, 2009
Human adenovirus type 5 infection causes the disruption of structures in the cell nucleus termed promyelocytic leukaemia (PML) protein nuclear domains or ND10, which contain the PML protein as a critical component. This disruption is achieved through the
Araujo, Beech, Bernardi, Bernardi, Borden, Bourhis, Callaghan, Carvalho, Condemine, Condemine, Dalessio, Doucas, E. Emmott, Evans, Everett, Everett, Everett, Fagioli, Fagioli, Hoppe, Ishov, Janderova-Rossmeislova, Jensen, K. N. Leppard, Kalderon, Kelly, Liu, M. S. Cortese, Mohan, Nevels, Peng, Romero, Salomoni, Scaglioni, Shen, Sternsdorf, Stracker, T. Rich   +37 more
core   +1 more source