Acute Promyelocytic Leukemia in Four Year Old Female Child - A Case Report [PDF]
Journal of Krishna Institute of Medical Sciences University, 2014 Leukemia is the most common malignancy of childhood representing about 30 % of oncohematological diseases diagnosed in children less than 15 years of age.
Anirudha V. Kushtagi +3 more
doaj +2 more sources
, 2014 Acute promyelocytic leukemia (APL) is epitomized by the chromosomal translocation t(15;17) and the resulting oncogenic fusion protein PML-RARα. Although acting primarily as a transcriptional repressor, PML-RARα can also exert functions of transcriptional
Nadia Coltella +9 more
openalex +6 more sources
Current views on the genetic landscape and management of variant acute promyelocytic leukemia
Biomarker Research, 2021 Acute promyelocytic leukemia (APL) is characterized by the accumulation of promyelocytes in bone marrow. More than 95% of patients with this disease belong to typical APL, which express PML-RARA and are sensitive to differentiation induction therapy ...
Xiang Zhang +3 more
semanticscholar +1 more source
Addition of Arsenic Trioxide into Induction Regimens Could Not Accelerate Recovery of Abnormality of Coagulation and Fibrinolysis in Patients with Acute Promyelocytic Leukemia. [PDF]
PLoS ONE, 2016 AIM:All-trans retinoic acid combined to anthracycline-based chemotherapy is the standard regimen of acute promyelocytic leukemia. The advent of arsenic trioxide has contributed to improve the anti-leukemic efficacy in acute promyelocytic leukemia.
Ye Zhang +4 more
doaj +1 more source
A case report of TBL1XR1-RARB positive pediatric acute promyelocytic leukemia and literature review. [PDF]
Front OncolDu C +5 more
europepmc +3 more sources
Extramedullary acute promyelocytic leukemia [PDF]
Cancer, 1996 Extramedullary acute promyelocytic leukemia (APL) is rare, and said to be more common after treatment with all-trans retinoic acid (ATRA) than after any other treatment.The case of a child with extramedullary relapse of APL after initial treatment with ATRA and that of an adult whose initial treatment was chemotherapy are presented, and the literature ...
P H, Wiernik +3 more
openaire +2 more sources
Influence of white blood cell count trajectories on the risk of differentiation syndrome during induction therapy with all-trans-retinoic acid and arsenic trioxide in pediatric acute promyelocytic leukemia. [PDF]
Front PediatrFu H, Liu Y, Hu S.
europepmc +3 more sources
Acute promyelocytic leukemia (APL): a review of the literature
OncoTarget, 2020 Acute Promyelocytic Leukemia (APL) is characterized by a block in differentiation where leukemic cells are halted at the promyelocyte stage. A characteristic balanced chromosomal translocation between chromosomes 15 and 17 t (15;17) (q24; q21) is seen in
J. Jimenez +3 more
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Journal of Nepal Paediatric Society, 2018 Acute promyelocytic leukemia (APL) is the most malignant form of acute leukemia, relatively uncommon in children, rapidly fatal if untreated and several developments have paved the way to make this disease curable. We report a first case to our knowledge in Nepal, a 12 years old boy who was diagnosed as APL and treated with vesanoid 14 years back and ...
Yuranga Weerakkody +2 more
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Cancers, 2020 Although acute promyelocytic leukemia (APL) is one of the most characterized forms of acute myeloid leukemia (AML), the molecular mechanisms involved in the development and progression of this disease are still a matter of study.
A. Liquori +5 more
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