Results 31 to 40 of about 26,607 (237)

Treatment advances have not improved the early death rate in acute promyelocytic leukemia

Haematologica, 2012
Early mortality in acute promyelocytic leukemia has been reported to occur in less than 10% of patients treated in clinical trials. This study reports the incidence and clinical features of acute promyelocytic leukemia patients treated at Stanford ...
James Scott McClellan, Holbrook E. Kohrt, Steven Coutre, Jason R. Gotlib, Ravindra Majeti, Ash A. Alizadeh, Bruno C. Medeiros   +6 more
doaj   +1 more source

Targeting the acute promyelocytic leukemia-associated fusion proteins PML/RARα and PLZF/RARα with interfering peptides

, 2012
In acute promyelocytic leukemia (APL), hematopoietic differentiation is blocked and immature blasts accumulate in the bone marrow and blood. APL is associated with chromosomal aberrations, including t(15;17) and t(11;17).
Sabine Beez (123610), Beez, Sabine, Philipp Demmer, Elena Puccetti (66633), Philipp Demmer (123611), Puccetti, Elena, Elena Puccetti, Sabine Beez, Demmer, Philipp   +8 more
core   +1 more source

Targeting the MLL complex in acute leukemia [PDF]

, 2014
Chromosomal rearrangements leading mostly to fusion oncoproteins of the Mixed Lineage Leukemia (MLL) gene occur in about 10% of all patients with acute leukemia and are often associated with poor clinical outcome, emphasizing the need for new treatment ...
Méreau, Hélène
core   +1 more source

A giant thrombus in the right atrium of a patient with acute promyelocytic leukemia M3

Radiology Case Reports, 2023
Acute promyelocytic leukemia is a special type of acute myeloid leukemia. Patients with this disease are at high risk of complications. Right atrial thrombosis is a rare but potentially serious complication.
Pham Ngoc Thach, MD, Ho Tran Ban, MD, Huynh-Thi Vu Quynh, MD, Tran-Thi Thanh, MD, Phan Thao Nguyen, MD, Trinh Nguyen Ha Vi, MD, Tran Ba Hieu, MD, Nguyen Duc Chinh, MD, Tran Hoa, MD, Bui The Dung, MD, Nguyen Minh Duc, MD   +10 more
doaj   +1 more source

Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia

, 2005
The prognostic significance of FLT3 mutations in acute promyelocytic leukemia (APL) is not firmly established and is of particular interest given the opportunities for targeted therapies using FLT3 inhibitors.
Gilkes, Amanda F., Ellen Solomon, Linch, D C, Gale, Rosmary E., Burnett, Alan Kenneth, Gale, RE, David C. Linch, Pizzey, AR, Elizabeth Nugent, Keith Wheatley, Grimwade, D., Grimwade, D, Solomon, E, Pizzey, A R, Solomon, Ellen, Kenneth I. Mills, Swirsky, D, Pizzey, A.R., Burnett, A K, Alan K. Burnett, Hills, Robert Kerrin, Swirsky, David, Kottaridis, Panagiotis D., Grimwade, David, Linch, David C., ?, ?, Hills, R., David Swirsky, Gale, R E, Gilkes, A F, Kottaridis, PD, Solomon, E., Robert Hills, Linch, D.C., Arnold R. Pizzey, Nugent, E., Rosemary E. Gale, Mills, KI, Nugent, Elizabeth, Gale, R.E., Swirsky, D., Hills, Robert, Hills, R, NCRI Adult Leukaemia Working Party, David Grimwade, Kottaridis, P D, Linch, DC, Wheatley, K., Amanda F. Gilkes, Wheatley, Keith, Gilkes, AF, Nugent, E, Panagiotis D. Kottaridis, Mills, K I, Mills, Ken; id_orcid, Kottaridis, P.D., Burnett, AK, Burnett, A.K., Mills, Kenneth I., Gilkes, A.F., Wheatley, K, Pizzey, Arnold R.   +61 more
core   +1 more source

Case report: A rare case of acute myeloid leukemia with CPSF6–RARG fusion resembling acute promyelocytic leukemia

Frontiers in Oncology, 2022
Retinoic acid receptor gamma (RARG) gene rearrangement has been reported in several acute myeloid leukemia (AML) patients. They resemble classical acute promyelocytic leukemia (APL) patients in clinical features, morphology, and immunophenotype but do ...
Junmei Zhao, Wentao Wang, Li Yan, Xi Chen, Wen Li, Wanying Li, Tingting Chen, Lunhua Chen   +7 more
doaj   +1 more source

Reduced SLIT2 is Associated with Increased Cell Proliferation and Arsenic Trioxide Resistance in Acute Promyelocytic Leukemia [PDF]

, 2020
Simple SummaryIn solid tumors, the altered expression of embryonic genes such as the SLIT-ROBO family has been associated with poor prognosis, while little is known about their role in acute myeloid leukemia (AML).
Jan Jacob Schuringa, Arnold Ganser, Chauffaille, Maria de Lourdes, Kerbauy, Fabio, Keating, Armand, Maria de Lourdes Chauffaille, Melo, Raul A. M., Gloria, Ana B., Luíse A. A. Simões, Diego A. Pereira-Martins, Rosane I. Bittencourt, Martin S. Tallman, Richard Dillon, Isabel Weinhäuser, Koury, Luisa C., Lo-Coco, Francesco, Bianco, Thiago M., Emanuele Ammatuna, Nancy Berliner, Armand Keating, Francesco Lo-Coco, Antonio R. Lucena-Araujo, Silveira, Douglas R., Bob Löwenberg, Fábio Kerbauy, Katia Pagnano, Weinhauser, Isabel, Pereira-Martins, Diego A., Simoes, Luise A. A., Valk, Peter, Fagundes, Evandro M., Tallman, Martin S., Berliner, Nancy, Lucena-Araujo, Antonio R., Cesar Ortiz, Miguel A. Sanz, Douglas R. Silveira, Eduardo M. Rego, Sanz, Miguel A., Ana B. Gloria, Raul C. Ribeiro, Raul A. M. Melo, Elenaide C. Nunes, Evandro M. Fagundes, Pasquini, Ricardo, Rego, Eduardo M., Nunes, Elenaide C., Cleide L. Araujo, Araujo, Cleide L., Thiago M. Bianco, Ganser, Arnold, Schuringa, Jan Jacob, Luisa C. Koury, Ribeiro, Raul C., Weinhauser, Isabel; id_orcid, Ammatuna, Emanuele, Ortiz, Cesar, Bittencourt, Rosane I., Pagnano, Katia, Ricardo Pasquini, Dillon, Richard, Peter Valk, Lowenberg, Bob   +62 more
core   +1 more source

Acute myeloid leukemia with fusion resembling acute promyelocytic leukemia, initially presenting as sweet syndrome: A case report and literature review

Journal of International Medical Research
Some subtypes of acute myeloid leukemia share morphologic, immunophenotypic, and clinical features of acute promyelocytic leukemia but lack a promyelocytic leukemia–retinoic acid receptor alpha fusion gene.
Huan Liu, Guo-Xia Liu, Feng-Hai Liu, Shu-Guo Wang   +3 more
doaj   +1 more source

Relapsed acute promyelocytic leukemia in a hemodialysis-dependent patient treated with arsenic trioxide: a case report

Journal of Medical Case Reports, 2012
Introduction In the relapsed setting, arsenic trioxide remains the backbone of treatment. Scant literature exists regarding treatment of relapsed acute promyelocytic leukemia in patients with renal failure.
Emmons Gregory S, Steingart Richard H, Stewart James A, Mertens Wilson C   +3 more
doaj   +1 more source

Micro‐Galvanic Coupling Programs the Therapeutic Zinc Ion Window to Reconfigure Immune Cascades for Pro‐Regenerative Bone Healing

Advanced Science, EarlyView.
This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun, Bo Jia, Jiahui Shi, Shuang Li, Guo Bao, Dong Bian, Kai Chen, Junlong Tan, Xuenan Gu, Yan Guan, Yu Qin, Xinhua Qu, Xiaogang Wang, Yufeng Zheng, Hongtao Yang   +14 more
wiley   +1 more source