Results 11 to 20 of about 43,912 (220)

TGFβ-Mediated Overexpression of Podoplanin Serves as a Potential Diagnostic Biomarker in Acute Promyelocytic Leukemia. [PDF]

Mol Carcinog
ABSTRACT Early diagnosis of acute promyelocytic leukemia (APL), driven by PML‐RARA oncoprotein, is vital for survival, as delays can cause fatal coagulopathy without prompt therapeutic intervention of all‐trans retinoic acid and arsenic trioxide. Although APL is diagnosed using microscopy, immunophenotyping, and FISH/PCR for PML‐RARA, morphological ...
Maity A, Kumar R, Dutta M, Mishra A, Gawde J, Patil J, Kadam D, Mirgh S, Gokarn A, Jain H, Nayak L, Bagal B, Punatar S, Sengar M, Khattry N, Subramanian PG, Tembhare P, Hasan SK.   +17 more
europepmc   +2 more sources

Severe acute axonal neuropathy following treatment with arsenic trioxide for acute promyelocytic leukemia: a case report [PDF]

, 2016
Peripheral neuropathy is a common complication of arsenic toxicity. Symptoms are usually mild and reversible following discontinuation of treatment. A more severe chronic sensorimotor polyneuropathy characterized by distal axonal-loss neuropathy can be ...
Kuhn, Marcus, Nabergoj, Mithia, Sammartin, Kety, Vianello, Fabrizio   +3 more
core   +3 more sources

The CEBPA gene is down-regulated in acute promyelocytic leukemia and its upstream promoter, but not the core promoter, is highly methylated

Haematologica, 2011
Impairment of CCAAT Enhancer Binding Protein alpha (CEBPA) function is a common finding in acute myeloid leukemia; nevertheless, its relevance for acute promyelocytic leukemia pathogenesis is unclear.
Bárbara Amélia Santana-Lemos, Ana Paula Alencar de Lima Lange, Mariana Tereza de Lira Benício, Thiago Donizete da Silva José, Antônio Roberto Lucena-Araújo, Alexandre Krause, Carolina Hassibe Thomé, Eduardo Magalhães Rego   +7 more
doaj   +1 more source

Role of vitamin A/retinoic acid in regulation of embryonic and adult hematopoiesis [PDF]

, 2017
Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being ...
Adamo, Ana Cañete, Arguello, Cardoso, Dary, De Luca, Elena Cano, Gebremedhin, Gerster, Grande, Guo, Haussler, Kuwata, Lo-Coco, McLaren, Nervi, North, Ottersbach, O’Donnell, Ramón Muñoz-Chápuli, Rita Carmona, Ross, Testa, West   +23 more
core   +4 more sources

Preferential expression of the transcription coactivator HTIF1alpha gene in acute myeloid leukemia and MDS-related AML [PDF]

, 2002
HTIF1α, a transcription coactivator which is able to mediate RARα activity and functionally interact with PML, is encoded by a gene on chromosome 7q32–34, which is a critical region in acute myeloid leukemias (AML). With the assumption that this gene may
AGUIARI, Gianluca, CASTOLDI, GL, CUNEO, Antonio, DE ANGELI, C, DEL SENNO, Laura, GANDINI, D, LANZA, F, MANZATI, E, PANDOLFI, PP   +8 more
core   +1 more source

Arsenic trioxide is required in the treatment of newly diagnosed acute promyelocytic leukemia. Analysis of a randomized trial (APL 2006) by the French Belgian Swiss APL group

Haematologica, 2018
In standard-risk acute promyelocytic leukemia, recent results have shown that all-trans retinoic acid plus arsenic trioxide combinations are at least as effective as classical all-trans retinoic acid plus anthracycline-based chemotherapy while being less
Lionel Adès, Xavier Thomas, Agnes Guerci Bresler, Emmanuel Raffoux, Olivier Spertini, Norbert Vey, Tony Marchand, Christian Récher, Arnaud Pigneux, Stephane Girault, Eric Deconinck, Claude Gardin, Olivier Tournilhac, Jean Francois Lambert, Patrice Chevallier, Stephane de Botton, Julie Lejeune, Hervé Dombret, Sylvie Chevret, Pierre Fenaux   +19 more
doaj   +1 more source

A case of acute myeloid leukemia with promyelocytic features characterized by expression of a novel RARG-CPSF6 fusion [PDF]

, 2018
Key Points Novel RARG-CPSF6 fusion in an AML case with promyelocytic features and no evidence of PML-RARA or X-RARA fusion. Gene fusions involving RARG can initiate AML with promyelocytic morphological features.
Duncavage, Eric J., Griffith, Malachi, Griffith, Obi L., Hassan, Anjum, Lee, Yi-Shan, Miller, Christopher A., O\u27Laughlin, Michelle D., Schmidt, Heather, Skidmore, Zachary L., Tian, Ling, Tricarico, Christopher, Uy, Geoffrey L., Wartman, Lukas D., Welch, John S.   +13 more
core   +2 more sources

Acute promyelocytic leukemia with increased bone marrow reticulin fibrosis: Description of three cases and review of the literature

Hematology/Oncology and Stem Cell Therapy, 2018
Pathologic increase in bone marrow reticulin fibrosis can be present in many malignant hematopoietic diseases. In acute leukemia, one-third of patients have some degree of marrow reticulin fibrosis at presentation, which is thought to be related to ...
Iman Abou Dalle, Samer Nassif, Ali Bazarbachi   +2 more
doaj   +1 more source

Acute Myeloid Leukemia and Acute Promyelocytic Leukemia

Hematology, 2003
AbstractThe therapeutic approach to the patient with acute myeloid leukemia (AML) currently evolves toward new frontiers. This is particularly apparent from the entree of high-throughput diagnostic technologies and the identification of prognostic and therapeutic targets, the introduction of therapies in genetically defined subgroups of AML, as well as
Bob, Löwenberg, James D, Griffin, Martin S, Tallman   +2 more
openaire   +2 more sources

The relevance of preferentially expressed antigen of melanoma (PRAME) as a marker of disease activity and prognosis in acute promyelocytic leukemia

Haematologica, 2008
Background The gene for preferentially expressed antigen of melanoma (PRAME) has been shown to be over-expressed in acute promyelocytic leukemia, but its actual incidence and clinical impact are still unknown.Design and Methods We studied PRAME ...
Carlos Santamaría, María Carmen Chillón, Ramón García-Sanz, Ana Balanzategui, María Eugenia Sarasquete, Miguel Alcoceba, Fernando Ramos, Teresa Bernal, José Antonio Queizán, María Jesús Peñarrubia, Pilar Giraldo, Jesús F. San Miguel, Marcos Gonzalez   +12 more
doaj   +1 more source