Results 21 to 30 of about 26,607 (237)

Efficacy and the Adverse Effects of Oral Versus Intravenous Arsenic for Acute Promyelocytic Leukemia: A Meta-Analysis of Randomized-Controlled Studies

Technology in Cancer Research & Treatment, 2020
Acute promyelocytic leukemia, a subtype of acute myeloid leukemia, is highly curable. In subgroup of patients with non-high-risk acute promyelocytic leukemia, intravenous arsenic trioxide plus all-trans-retinoic acid is considered the preferred regimen ...
Natthaporn Sasijareonrat MD, Nikolaus Jahn MD, Patompong Ungprasert MD, MS, Weerapat Owattanapanich MD   +3 more
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Extramedullary acute promyelocytic leukemia [PDF]

Cancer, 1996
Extramedullary acute promyelocytic leukemia (APL) is rare, and said to be more common after treatment with all-trans retinoic acid (ATRA) than after any other treatment.The case of a child with extramedullary relapse of APL after initial treatment with ATRA and that of an adult whose initial treatment was chemotherapy are presented, and the literature ...
P H, Wiernik, R, De Bellis, P, Muxi, J P, Dutcher   +3 more
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Cellulitis with Leukocytopenia as an Initial Sign of Acute Promyelocytic Leukemia

Case Reports in Dermatology, 2012
Patients with hematologic malignancies are immunosuppressive and may develop cutaneous or invasive infections as a primary sign of immune suppression.
Sachiko Sakamoto, Naoki Oiso, Masakatsu Emoto, Shusuke Uchida, Ayaka Hirao, Yoichi Tatsumi, Itaru Matsumura, Akira Kawada   +7 more
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Identification of cooperating genetic events in acute leukemia [PDF]

, 2009
The genetic alterations associated with acute leukemia can be divided into two functional groups. The class I mutations enhance cellular proliferation and survival by constitutive activation of mainly protein tyrosine kinases signaling pathways.
Liu, Ting
core   +1 more source

Molecular basis for the diagnosis and treatment of acute promyelocytic leukemia

Revista Brasileira de Hematologia e Hemoterapia, 2012
Acute promyelocytic leukemia is characterized by gene rearrangements that always involve the retinoic acid receptor alpha on chromosome 15. In the majority of patients t(15;17) is detected, which generates the promyelocytic leukemia gene/retinoic acid ...
Sarah Cristina Bassi, Eduardo Magalhães Rego   +1 more
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Frontline Management of Acute Promyelocytic Leukemia

, 2023
In the frontline management of acute promyelocytic leukemia (APL), prevention of early deaths and the selection of the optimal frontline induction strategies incorporating arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) are the more important ...
Singh, Gill Harinder Harry
core   +1 more source

Co-operative leukemogenesis in acute myeloid leukemia and acute promyelocytic leukemia reveals C/EBPα as a common target of TRIB1 and PML/RARA

Haematologica, 2016
The PML/RARA fusion protein occurs as a result of the t(15;17) translocation in the acute promyelocytic leukemia subtype of human acute myeloid leukemia.
Karen Keeshan, Pauline Vieugué, Shahzya Chaudhury, Loveena Rishi, Coline Gaillard, Lu Liang, Elaine Garcia, Takuro Nakamura, Nader Omidvar, Scott C. Kogan   +9 more
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Notch signaling in acute promyelocytic leukemia [PDF]

Leukemia, 2013
Acute promyelocytic leukemia (APL) is initiated by the PML-RARA (PR) fusion oncogene and has a characteristic expression profile that includes high levels of the Notch ligand Jagged-1 (JAG1). In this study, we used a series of bioinformatic, in vitro, and in vivo assays to assess the role of Notch signaling in human APL samples, and in a PML-RARA knock-
Grieselhuber, Nicole R., Klco, Jeffery M., Verdoni, Angela M., Lamprecht, Tamara, Sarkaria, Shawn M., Wartman, Lukas D., Ley, Timothy J.   +6 more
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Predictors of early death, serious hemorrhage, and differentiation syndrome in Japanese patients with acute promyelocytic leukemia.

, 2020
Significant advancements have been achieved with regard to the outcomes of acute promyelocytic leukemia (APL) patients through the introduction of all-trans retinoic acid; however, early hemorrhagic death and differentiation syndrome remain the major ...
8178, 8179, 8176, 8177, OHTAKE, Shigeki, 8170, 8171, 8174, USUI, Noriko, 8175, 8172, 8173, 0000-0003-4450-0106, 8189, 8187, 8188, FUJIMAKI, Katsumichi, KIYOI, Hitoshi, 8181, 8182, TAKESHITA, Akihiro, 8180, 8185, 8186, 8183, 8184, NAOE, Tomoki, 806, TANIGUCHI, Yasuhiro, YANADA, Masamitsu, MINAMIGUCHI, Hitoshi, SAWA, Masashi, MIYAZAKI, Yasushi, SAKURA, Toru, UEDA, Yasunori, 8190, 8191, 0000-0001-7504-6677, MATSUMURA, Itaru, FUJITA, Hiroyuki, DOBASHI, Nobuaki, 0000-0003-2378-7865, 8167, 8168, ASOU, Norio, 8169, IWANAGA, Masako, ATSUTA, Yoshiko, SUZUKI, Rikio, HAGIHARA, Maki, TAMAKI, Shigehisa, 南口, 仁志, UCHINO, Yoshihito, TOMITA, Akihiro, MAEDA, Yoshinobu, KOBAYASHI, Yukio   +55 more
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Acute Promyelocytic Leukemia in Four Year Old Female Child - A Case Report [PDF]

Journal of Krishna Institute of Medical Sciences University, 2014
Leukemia is the most common malignancy of childhood representing about 30 % of oncohematological diseases diagnosed in children less than 15 years of age.
Anirudha V. Kushtagi, Mihir J. Bhalodia, Mahesh H. Karigoudar, Jyotirling Savle   +3 more
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