Results 81 to 90 of about 264,861 (313)

Oral arsenic trioxide incorporation into frontline treatment with all‐trans retinoic acid and chemotherapy in newly diagnosed acute promyelocytic leukemia: A 5‐year prospective study

Cancer, 2019
Strategies using oral arsenic trioxide (As2O3) are efficacious in relapsed acute promyelocytic leukemia (APL), but they have not been examined in newly diagnosed cases.
H. Gill, C. Kumana, Rita Yim, Y. Hwang, T. Chan, S. Yip, Harold-Kwok Lee, V. Mak, J. S. Lau, Chi-chung Chan, Bonnie Kho, R. Wong, Wa Li, Shek-Yin Lin, C. Lau, H. Ip, R. Leung, C. Lam, Y. Kwong   +18 more
semanticscholar   +1 more source

Prospective validation of podoplanin expression as a diagnostic biomarker of acute promyelocytic leukemia

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Acute promyelocytic leukemia (APL) is a medical emergency that needs immediate diagnosis and treatment. Podoplanin, a transmembrane glycoprotein that binds CLEC‐2 on platelets, was recently demonstrated to be abnormally expressed in leukemic blasts in APL, as opposed to other forms of AML, in a study using thawed primary cells.
Camilla Maria de Alencar Saraiva, Carla Roberta Peachazepi Moraes, Bruno Kosa Lino Duarte, Gislaine Borba Oliveira, Herton Luiz Alves Sales Filho, Paula de Melo Campos, Sara Teresinha Olalla Saad, Erich Vinicius De Paula   +7 more
wiley   +1 more source

Salvianolic Acid B Prevents Arsenic Trioxide-Induced Cardiotoxicity In Vivo and Enhances Its Anticancer Activity In Vitro [PDF]

, 2013
Clinical attempts to reduce the cardiotoxicity of arsenic trioxide (ATO) without compromising its anticancer activities remain to be an unresolved issue.
Chen, Rongchang, Dong, Xi, Luo, Yun, Qin, Meng, Sun, Guibo, Sun, Hong, Sun, Xiaobo, Wang, Min, Wu, Ping, Yao, Fan, Zhang, Qiang   +10 more
core   +3 more sources

Acute promyelocytic leukemia presenting as an extradural mass

Revista Brasileira de Hematologia e Hemoterapia, 2011
Acute promyelocytic leukemia is potentially a highly curable type of leukemia that usually presents with pancytopenia, coagulopathies and bleeding. We describe a case of an unusual presentation of acute promyelocytic leukemia.
Henrique Bittencourt, Antonio Lucio Teixeira Junior, Ana Beatriz Firmato Glória, Ana Flávia Leonardi Tiburcio Ribeiro, Evandro Maranhão Fagundes   +4 more
doaj   +1 more source

Monocyte maturation pattern by flow cytometry expression of CD64, CD300e, and CD14 correlates to presence of myeloid neoplasm and helps identify blast equivalents in the setting of monocytic neoplasm

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract CD300e is a marker of mature monocytes in flow cytometry; however, there is limited detailed information on staining patterns in conjunction with other monocyte markers. We evaluated the flow cytometric staining patterns of CD64, CD14, and CD300e in 12 negative and 33 positive peripheral blood specimens and 16 negative and 56 positive bone ...
Jenny Zhang, Jacob Kaplan, Elizabeth Courville   +2 more
wiley   +1 more source

Management of elderly patients with acute promyelocytic leukemia: progress and problems [PDF]

, 2013
Despite substantial progress in the management and outcome of acute promyelocytic leukemia (APL) during the last decades, older age remains a prominent negative prognostic factor.
Eva Lengfelder, Florian Nolte, Wolf-Karsten Hofmann   +2 more
core   +1 more source

Molecular and hematologic relapses in adult patients with acute promyelocytic leukemia: a cohort study

Revista Brasileira de Hematologia e Hemoterapia
Objective: To evaluate factors predictive for relapse in a cohort of adult patients with acute promyelocytic leukemia monitored by molecular methods during consolidation and during at least one month of maintenance therapy.
Ilana de França Azevedo, Michelline Gomes Magalhães, Fernanda Ribeiro Souto, Washington Batista das Neves, Fárida Coeli de Barros Correia Melo, Eduardo Magalhães Rego, Raul Antônio Morais Melo   +6 more
doaj   +1 more source

2-Bromopalmitate targets retinoic acid receptor alpha and overcomes all-trans retinoic acid resistance of acute promyelocytic leukemia

Haematologica, 2019
Fatty acid oxidation dependency of leukemia cells has been documented in recent studies. Pharmacologic inhibition of fatty acid oxidation, thereby, displays significant effects in suppressing leukemia.
Ying Lu, Jin-Song Yan, Li Xia, Kang Qin, Qian-Qian Yin, Hong-Tao Xu, Meng-Qing Gao, Xiao-Ning Qu, Yu-Ting Sun, Guo-Qiang Chen   +9 more
doaj   +1 more source

Analysis of gamma-glutamyltransferase in acute promyelocytic leukemia patients undergoing arsenic trioxide treatment [PDF]

, 2021
Meijuan Sui, Wei Hong, Qian Zhang, Ruolin Xiu, Xiaohan Shen, Zhuo Zhang, Jin Zhou   +6 more
openalex   +1 more source

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source