Results 91 to 100 of about 2,279,754 (315)

Comparison of the National Institutes of Health Stroke Scale with disability outcome measures in acute stroke trials [PDF]

, 2005
<p><b>Background and Purpose:</b> Acute stroke trials typically use disability scales as their primary end point. Neurologic impairment scales such as the National Institutes of Health Stroke Scale (NIHSS) are possibly more sensitive to
Lees, K.R., Weir, C.J., Young, F.B.
core   +1 more source

Comprehensive Assessment of Arterial, Tissue, and Venous Collaterals for Evaluating the Infarct Growth Rate: The Multimodal Collateral Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto, Umberto Pensato, Ilaria Casetta, Giorgio U. Marcello, Angelo Barra, Anna Poggesi, Edoardo Carlesi, Sara Mancini, Andrea Ginestroni, Vittorio Miele, Alessandro Padovani, Andrea Morotti, Enrico Fainardi   +12 more
wiley   +1 more source

Demographic, clinical and radiological characteristics of patients with acute ischemic stroke and acute symptomatic seizures [PDF]

Medicinski Podmladak
Introduction: A growing number of stroke survivors face various stroke complications, including acute symptomatic seizures. Symptomatic seizures are associated with longer hospitalizations, negative functional outcomes, and lower quality of life for ...
Baljak Anja, Kovačević Maša
doaj   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Effects of music-based group exercise in patients with acquired brain injury—a randomized controlled trial

Frontiers in Psychology
BackgroundCognitive impairment following acquired brain injury (ABI) is common. In this study, we investigated whether music-based group exercise (MBGE) is superior to standard therapy (ST) in improving cognitive deficits.
Mareike Schrader, Mareike Schrader, Tobias Strank, Annette Sterr, Stephan Bamborschke, Stephan Bamborschke, Christian Dohle, Christian Dohle, Christian Dohle   +8 more
doaj   +1 more source

Using historical lesion volume data in the design of a new phase II clinical trial in acute stroke [PDF]

, 2009
<p><b>Background and Purpose:</b> Clinical research into the treatment of acute stroke is complicated, is costly, and has often been unsuccessful.
Bolland, Kim, Lees, Kennedy J., Lihic, A., Lees, Kennedy, Ali, M., Lihic, Anela, Lees, K.R., Bolland, K., Whitehead, J., Ali, Myzoon, Valdes-Marquez, E., Whitehead, John, Valdés-Márquez, Elsa, Lees, K.   +13 more
core   +1 more source

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Penetrating neck trauma: a comprehensive review

Trauma Surgery & Acute Care Open
Although the overall incidence is low, penetrating neck trauma can result in devastating injuries. The traditional zonal approach is being increasingly abandoned in favor of selective approaches, especially as mandatory exploration can result in non ...
Kenji Inaba, Martin Schreiber, Kazuhide Matsushima, Christopher Barrett, ANNA WHITE, Reynold Henry, Daniel Lammers, Lindsey Loss   +7 more
doaj   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Gavestinel does not improve outcome after acute intracerebral hemorrhage: an analysis from the GAIN International and GAIN Americas studies [PDF]

, 2005
<p><b>Background and Purpose:</b> Glycine Antagonist in Neuroprotection (GAIN) International and GAIN Americas trials were prospectively designed, randomized, placebo-controlled trials of gavestinel, a glycine-site antagonist and ...
Lees, K.R., Brown, D.L., Levin, B., Pittman, J.G., Ordronneau, P., Sacco, R.L., Davis, S., Derosa, J.T., Thompson, J.L.P., Haley, E.C., ORDRONNEAU P, DEROSA J. T, CLARKE HALEY, E. JR, LEVIN, Bruce, THOMPSON J. L. P, PITTMAN J. C, DAVIS, Stephen, LEES, K. L, BROWN, D. L, FOR THE GAIN AMERICAS AND GAIN, DAVIS S, CAROLEI, ANTONIO, PITTMAN, John G, DEROSA, Janet T, ORDRONNEAU, Paul, SACCO R. L, INTERNATIONAL INVESTIGATORS, LEVIN B, HALEY E. C, SACCO, Ralph L, THOMPSON, John L. P, LEES, Kennedy R, BROWN, Devin L   +32 more
core   +1 more source