Results 71 to 80 of about 507,051 (317)

Dose escalation of desmoteplase for acute ischemic stroke (DEDAS): evidence of safety and efficacy 3 to 9 hours after stroke onset [PDF]

, 2006
<p><b>Background and Purpose:</b> Desmoteplase is a novel plasminogen activator with favorable features in vitro compared with available agents.
Lees, K.R., Hacke, W.l, Sachara, C., Rowley, H.A., Furlan, A.J., Al, R.Y., Eyding, D., Albers, G.W., Soehngen, M., Warach, S.   +9 more
core   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

Development of a computerised decision aid for thrombolysis in acute stroke care

, 2015
Background - Thrombolytic treatment for acute ischaemic stroke improves prognosis, although there is a risk of bleeding complications leading to early death/severe disability. Benefit from thrombolysis is time dependent and treatment must be administered
Ford, Gary, Kray, Christian, Thomson, Richard G., Price, Christopher, Ford, Gary A., Nesbitt, Daniel J., Flynn, Darren, Nesbitt, Daniel, McMeekin, Peter, Rodgers, Helen   +9 more
core   +1 more source

Stroke outcome in clinical trial patients deriving from different countries [PDF]

, 2008
<p><b>Background and Purpose:</b> Stroke incidence and outcome vary widely within and across geographical locations. We examined whether differences in index stroke severity, stroke risk factors, mortality, and stroke outcome across ...
Lyden, Patrick, Sacco, R.L., Atula, Sari, Lees, Kennedy R, Hacke, Werner, Marler, J.R., Marler, John R., Lees, K.R., Grotta, James, Sacco, Ralph L, Bath, Philip M W, Lyden, Patrick D., Sacco, Ralph, Grotta, J., Sacco, Ralph L., Lees, Kennedy R., Bath, Philip M.W., Bath, P.M.W., Ali, M., Ali, Myzoon, Lyden, P., Marler, John, Hacke, W., Grotta,, James, Marler, John R, Atula, S.   +25 more
core   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Measures of intracranial compartments in acute intracerebral haemorrhage: data from the Rapid Intervention with Glyceryl Trinitrate in Hypertensive Stroke-2 Trial (RIGHT-2)

Stroke and Vascular Neurology
Background and purpose Intracerebral haemorrhage volume (ICHV) is prognostically important but does not account for intracranial volume (ICV) and cerebral parenchymal volume (CPV).
Joanna M Wardlaw, Philip M Bath, Lisa J Woodhouse, Nikola Sprigg, Zhe Kang Law, Kailash Krishnan, Rob A Dineen   +6 more
doaj   +1 more source

Influence of age on outcome from thrombolysis in acute stroke: a controlled comparison in patients from the Virtual International Stroke Trials Archive (VISTA) [PDF]

, 2010
<p><b>Background and Purpose:</b> Thrombolysis for acute ischemic stroke in patients aged >80 years is not approved in some countries due to limited trial data in the very elderly.
Diener, H.-C., Lees, K.R., Mishra, N.K., Kennedy R. Lees, Lyden, P.D., Erich Bluhmki, Bluhmki, E., Nishant Kumar Mishra, Patrick D. Lyden, Hans-Christoph Diener   +9 more
core   +1 more source

Location‐Specific Hematoma Volume Predicts Early Neurological Deterioration in Supratentorial ICH

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Early neurological deterioration (END) adversely affects outcomes in patients with intracerebral hemorrhage (ICH). This study aimed to determine the location‐specific hematoma volumes for END in supratentorial ICH patients. Methods We retrospectively analyzed supratentorial ICH patients presenting from two prospective cohorts.
Zuoqiao Li, Guilin Meng, Zijie Wang, Xiao Hu, Jing Cheng, Chu Chen, Tiannan Yang, Jiaxin Luo, Zizhen Meng, Xueyun Liu, Qi Li   +10 more
wiley   +1 more source

APIC 2019 Meeting - Advanced Peripheral Interventions Course - Acute Stroke Intervention Course

Sakarya Tıp Dergisi, 2019
APIC 2019 Meeting - Advanced Peripheral Interventions Course - Acute Stroke Intervention ...
Apic 2019 Meeting - Advanced Peripheral İnterventions Course - Acute Stroke Intervention Course
doaj  

Prevalence of cognitive morbidity including delirium in 51,202 emergency hospital admissions across 29 medical and surgical specialties in ORCHARD-EPR: a cross-sectional studyResearch in context

EClinicalMedicine
Summary: Background: Older people account for a growing proportion of unplanned hospital admissions and many have complex conditions. However, there are few data on cognitive morbidity (delirium, dementia and low cognitive test score) by specialty to ...
Emily Louise Boucher, Sarah Catherine Smith, Sudhir Singh, Sasha Shepperd, Sarah Tamsin Pendlebury   +4 more
doaj   +1 more source