Results 61 to 70 of about 2,279,754 (315)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The Virtual International Stroke Trials Archive [PDF]

, 2007
Background and Purpose - Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal.
Donnan, Geoffrey A., Kaste, M., HENNERICI, Michael G, Teal, P., Gregson, B.A., Hacke, Werner, Marler, J.R., Marler, John R., Fisher, M., GREGSON, Barbara A, Wahlgren, Nils-Gunnar, Curram, John, Grotta, J., MARLER, John R, Davis, Stephen M., Sacco, Ralph L., Donnan, G.A., Myzoon, Ali, Bath, Philip M.W., Teal, Philip, WEIR, Christopher J, Weir, C.J., Gregson, Barbara A., Fisher, Marc, Hommel, Marc, Hacke, W., BATH, Philip M. W, Sacco, R.L., Diener, Hans-Christoph, Warach, S., DONNAN, Geoffrey A, Hennerici, Michael G., Wahlgren, N.-G., Lees, K.R., Grotta, James, Hennerici, M.G., Kaste, Markku, Weir, Christopher J., Warach, Steven, Lees, Kennedy R., DAVIS, Stephen M, Bath, P.M.W., Ali, M., Curram, J., Diener, H.-C., Ali, Myzoon, Davis, S.M., SACCO, Ralph L, Hommel, M., LEES, Kennedy R   +49 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Can the ischemic penumbra be identified on noncontrast CT of acute stroke? [PDF]

, 2007
<p><b>Background and Purpose:</b> Early ischemic changes on noncontrast CT in acute stroke include both hypoattenuation and brain swelling, which may have different pathophysiological significance.</p> <p><b>Methods:
Muir, K.W., McCormick, M., Baird, T., Coutts, S.B., Walker, L., Baird-Gunning, J.   +5 more
core   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Additional outcomes and subgroup analyses of NXY-059 for acute ischemic stroke in the SAINT I trial [PDF]

, 2006
<p><b>Background and Purpose:</b> NXY-059 is a free radical-trapping neuroprotectant demonstrated to reduce disability from ischemic stroke. We conducted analyses on additional end points and sensitivity analyses to confirm our findings.
Lees, K.R., Diener, H.-C., Shuaib, A., Zivin, J.A., Davis, S.M., Wasiewski, W., Lyden, P., Emeribe, U., Ashwood, T., Hardemark, H.G., Davalos, A., Grotta, J.   +11 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

National Incidence of Intracranial Haemorrhage–Related Hospitalisations and Mortality in England 2014–2019

Stroke Research and Treatment
Conclusion: The majority of ICrH acute hospitalisations (59.7%) were atraumatic. Sex differences were seen in outcome measurements: males had a higher overall incidence of hospitalisation; however, females had a higher incidence of atraumatic ICrH ...
Katherine J. Creeper, Andrew C. Stafford, Allycia MacDonald, Arvind Chandratheva, Alexander T. Cohen   +4 more
doaj   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source