Results 71 to 80 of about 786,429 (286)

Acute and subchronic oral toxicity assessments of Combretum micranthum (Combretaceae) in Wistar rats

Toxicology Reports, 2020
Background: Combretum micranthum (CM) (Combretaceae) is widely used in traditional medicine throughout West Africa for the treatment of diabetes, hypertension, inflammation, malaria and liver ailments.
Mabozou Kpemissi, Kossi Metowogo, Mamatchi Melila, Veeresh P. Veerapur, Mihai Negru, Marian Taulescu, Adrian-Valentin Potârniche, Doddamavattur Shivalingaiah Suhas, Tumbadi Adinarayanashetty Puneeth, Sachidananda Vijayakumar, Kwashie Eklu-Gadegbeku, Kodjo Aklikokou   +11 more
doaj   +1 more source

Experimental evolution reveals high insecticide tolerance in Daphnia inhabiting farmland ponds [PDF]

, 2015
Exposure of nontarget populations to agricultural chemicals is an important aspect of global change. We quantified the capacity of natural Daphnia magna populations to locally adapt to insecticide exposure through a selection experiment involving ...
Agra, Agra, Angel, Barata, Carriere, Cerbin, Colbourne, Coors, Crawley, De Meester, Decaestecker, Declerck, Goussen, Hebert, Hoffman, Jansen, Kerr, Klüttgen, Lampert, Levinton, McCullagh, Medina, Messiaen, Miner, Muyssen, Naddy, Parker, Raymond, Saro, Sibly, Tanaka, Van Doorslaer, Van Doorslaer, Van Straalen, Walker, Waterfield, Wheeler   +36 more
core   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Acute Toxic Effects of Zinc Oxide Nanoparticle and Zinc Chloride on Daphnia magna (Straus)

Trakya University Journal of Natural Sciences, 2017
The acute toxicities of zinc oxide nanoparticle (ZnO NP), zinc chloride (ZnCl2) and their mixtures of different concentrations (0.75, 1.5, 3, 6 and 12ppm) on Daphnia magna (Straus, 1820) were investigated at 24, 48 and 72 hours by employing the static ...
Şeyda Fikirdeşici Ergen
doaj   +1 more source

Acute and repeated dose 60-day oral toxicity assessment of chemically characterized Berberis hispanica Boiss. and Reut in Wistar rats

Open Chemistry, 2021
Berberis hispanica Boiss. & Reut (B. hispanica) belongs to the family Berberidaceae, which is currently used in traditional medicines. This article aimed to study the phytochemical composition and acute and subacute toxicity of B.
El Fakir Loubna, Bourhia Mohammed, Salamatullah Ahmad Mohammad, Alzahrani Abdulhakeem, Ullah Riaz, Ezzeldin Essam, Mostafa Gamal A., Bari Ahmed, Alaoui Tajelmolk, Gmouh Said, Benbacer Laila, Zaid Abdelhamid   +11 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Toxicity and Safety Profiles of Methanolic Extract of Pistacia integerrima J. L. Stewart ex Brandis (PI) for Wistar Rats

Journal of Pharmacopuncture, 2016
Objectives: The goals of this research were to evaluate acute (single-dose) and sub-acute (repeated-dose) toxicity profiles of methanolic extract of Pistacia integerrima J. L. Stewart ex Brandis (PI) for Wistar rats and to assess the safety profile of PI
Gotmi Sharwan, Parag Jain, Ravindra Pandey, Shiv Shankar Shukla   +3 more
doaj   +1 more source

Evaluation of the acute and sub-acute toxicity of the black caraway seed essential oil in Wistar rats

Toxicology Reports, 2019
The aim of the present study was to evaluate the acute toxicity as lethal dose 50% (LD50) and sub-acute toxicity of the black caraway Bunium persicum (Bioss) seed essential oil in male Wistar rats. The compounds of B.
Hadi Tabarraei, Jalal Hassan, Mohammad Reza Parvizi, Hannaneh Golshahi, Hossain keshavarz-Tarikhi   +4 more
doaj   +1 more source

Evaluation of toxicity effect of Datura innoxia root extract to Clarias gariepinus fingerlings [PDF]

, 2003
Clarias gariepinus fingerlings were exposed 96 hours under laboratory conditions using static bioassays with continuous aeration to determine acute toxicity of Datura innoxia root extract. The LC sub(50) of the exposed fingerlings was 128.83 mg/L.
Ayuba, V.O., Ofojekwu, P.C.
core  

A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes’ toxicity [PDF]

, 2017
Octahedral rhenium cluster compound Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] has recently emerged as a very promising X-ray contrast agent for biomedical applications.
Alekseev, Alexander Y., Brylev, Konstantin A., Efremova, Olga A., Gulyaeva, Marina A., Ivanov, Anton A., Krasilnikova, Anna A., Kurskaya, Olga G., Mironov, Yuri V., Poveshchenko, Alexander F., Pozmogova, Tatiana N., Shestopalov, Alexander M., Shestopalov, Michael A., Shestopalova, Lidiya V., Solovieva, Anastasiya O.   +13 more
core   +1 more source