Results 171 to 180 of about 7,722 (194)

Momelotinib in JAK2 inhibitor-naïve myelofibrosis: pros and cons. [PDF]

Blood Cancer J
Gangat N, Tefferi A.
europepmc   +1 more source

Discoidin domain receptor 2 is an important modulator of BMP signaling during heterotopic bone formation. [PDF]

Bone Res
Wu F, Ge C, Pan H, Han Y, Mishina Y, Kaartinen V, Franceschi RT.   +6 more
europepmc   +1 more source

CD9-enriched extracellular vesicles from chemically reprogrammed basal progenitors of salivary glands mitigate salivary gland fibrosis. [PDF]

Bioact Mater
Park S, Yoon YJ, Hong Y, Yu J, Cho JM, Jeong YJ, Yu H, Jeong H, Lee H, Hwang S, Koh WG, Yang JY, Hyun KA, Jung HI, Lim JY.   +14 more
europepmc   +1 more source

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A Fibrodysplasia Ossificans Progressiva Patient with a Rare Missense Mutation in ACVR1 Detected on 18F-FDG PET/CT.

Joint Bone Spine, 2023
Fibrodysplasia ossificans progressiva (FOP) is an exceedingly rare human genetic disorder characterized by the progressive and incapacitating formation of ectopic bone outside of the skeleton.
H. Ni, Songhan Tang, Ying Zhang
semanticscholar   +1 more source

Abstract 4990: Dual inhibitor of ACVR1 and MEK 1/2 E6201 and PI3K/mTOR inhibitor paxalisib synergistically inhibit cell growth in DMG

Cancer Research, 2023
Diffuse midline glioma (DMG) is an aggressive pediatric glioma with no curative treatment options. Mutation in MAPK pathway is common in many DMG tumors, however, has not been largely explored before. E6201 is a dual inhibitor of ACVR1 and MEK 1/2.
Hyukje Kwon, Abigail Tindall, C. Eberhart, Jeffrey A. Rubens, Eric H. Raabe   +4 more
semanticscholar   +1 more source

Midline brain hamartomatous lesions in fibrodysplasia ossificans progressiva with ACVR1 mutations

Neuropathology (Kyoto. 1993), 2023
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by extensive heterotopic ossification of soft tissue structures leading to severe limitations in movement.
J. Kresak, Meggen A Walsh, Anthony Tuzzolo, Zehra Ordulu, J. Gregory   +4 more
semanticscholar   +1 more source

ACVR1 Drives Neuropathic Pain by Regulating NLRP3-Induced Neuronal Pyroptosis through the p38 and Smad1/5/8 Pathways.

Neuropharmacology
BACKGROUND Neuropathic pain is characterized by sustained pain hypersensitivity caused by nerve injury. The molecular mechanisms underlying this condition remain poorly understood.
Xiaoxu Zhang, Yuxin Miao, Zong-Xi Li, Hao-Ming Xu, Zejun Niu   +4 more
semanticscholar   +1 more source

Abstract 204: Targeting tumor-stroma interactions: Prognostic and therapeutic implications of the ACVR1-BMP7 axis in colorectal cancer

Cancer Research
The tumor microenvironment plays a critical role in colorectal cancer (CRC) progression, with stromal signatures closely linked to poor prognoses and resistance to chemotherapy.
N. Miyoshi, Shinya Kato, S. Fujino, Soichiro Minami, Rie Mizumoto, Rie Hayashi, Ken Haruma   +6 more
semanticscholar   +1 more source

Acvr2b receptors transduce all BMP signaling in the zebrafish gastrula and restrict Fibrodysplasia Ossificans Progressiva ACVR1-R206H signaling in a dose-dependent manner

bioRxiv
BMP signaling drives dorsoventral (DV) axial patterning in vertebrates and invertebrates, with BMP dimers recruiting tetrameric receptor complexes to phosphorylate SMADs that activate ventral target gene expression.
Jeet H. Patel, Benjamin Tajer, Jira White, Finn Warrick, Mary C. Mullins   +4 more
semanticscholar   +1 more source

DMG-59. Preclinical efficacy of JAK2/IRAK1/ACVR1 inhibitor pacritinib against diffuse midline glioma (DMG)

Neuro-Oncology Pediatrics
Pacritinib is a clinically-approved JAK2/IRAK1/ACVR1 inhibitor for the treatment of myelofibrosis. As JAK2 inhibition has shown utility against a range of tumors, including glioblastoma (GBM), we aimed to investigate its role in the treatment of ...
Matthew C Biery, Davina S Lau, Lily I Winter, Andrea Timpanaro, Edward Z. Song, Leonel Elena-Sanchez, Michael Meechan, Kelsey Nemec, Nicholas A Vitanza   +8 more
semanticscholar   +1 more source