Results 41 to 50 of about 7,648 (236)
Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer. [PDF]
, 2015 BackgroundUnderstanding cell signaling pathways that contribute to metastatic colon cancer is critical to risk stratification in the era of personalized therapeutics.
Akagi, Naomi +9 more
core +2 more sources
The Journal of Clinical Investigation, 2022 Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized by progressive and catastrophic heterotopic ossification (HO) of skeletal muscle and associated soft tissues.
John B. Lees-Shepard +8 more
doaj +1 more source
A case of Fibrodysplasia Ossificans Progressiva associated with a novel variant of the ACVR1 gene
Molecular Genetics & Genomic Medicine, 2021 Background Fibrodysplasia Ossificans Progressiva (FOP) is a rare autosomal dominant disease characterized by congenital malformation of the great toes and progressive heterotopic ossification of soft tissues leading to cumulative disability.
Serena Cappato +4 more
doaj +1 more source
Stem Cell Research, 2021 Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disorder of progressive ossification of skeletal muscle, fascia, tendons, and ligaments. Most FOP cases are caused by a heterozygous c.
Xiuli Huang +7 more
doaj +1 more source
Approaches Toward Improving the Prognosis of Pediatric Patients With Glioma: Pursuing Mutant Drug Targets With Emerging Small Molecules [PDF]
, 2014 Gliomas represent approximately 70% of all pediatric brain tumors and most of these are of astrocytic lineage, furthermore, malignant or high-grade astrocytoma account for approximately 20% of pediatric astrocytoma. Treatment options for pediatric glioma
Snape, Timothy J., Warr, Tracy
core +1 more source
Blood Advances, 2022 Key Points • Pacritinib exhibits fourfold higher potency for inhibition of the hepcidin regulator ACVR1 compared to momelotinib based on in vitro data.• Pacritinib is associated with an increase in red blood cell transfusion independence in patients with
S. Oh +14 more
semanticscholar +1 more source
Brown Fat Paucity Due to Impaired BMP Signaling Induces Compensatory Browning of White Fat [PDF]
, 2014 Summary Maintenance of body temperature is essential for survival of homeotherms. Brown adipose tissue (BAT) is a specialized fat tissue that is dedicated to thermoregulation1.
Cypess, Aaron M. +9 more
core +1 more source
Fibrodysplasia ossificans progressiva in a 3-year-old female patient
Boletín Médico del Hospital Infantil de México, 2023 Background: Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disease affecting connective tissue, primarily caused by de novo mutations of the ACVR1 gene.
Cecilia Moreira +9 more
doaj +1 more source
Transcriptomic analyses of regenerating adult feathers in chicken [PDF]
, 2015 Transcriptome Expression Data. Table of mapped reads to Galgal4 transcripts for all 15 data sets. FPKM (Fragments per kilobase of exon per million fragments mapped): normalized transcript abundance values for each gene in the indicated tissues.
Chen Siang Ng +16 more
core +6 more sources
Disease Models & Mechanisms, 2016 The ACVR1 gene encodes a type I receptor of bone morphogenetic proteins (BMPs). Activating mutations in ACVR1 are responsible for fibrodysplasia ossificans progressiva (FOP), a rare disease characterized by congenital toe malformation and progressive ...
Serena Cappato +11 more
doaj +1 more source