Results 41 to 50 of about 7,722 (194)
Brown Fat Paucity Due to Impaired BMP Signaling Induces Compensatory Browning of White Fat [PDF]
, 2014 Summary Maintenance of body temperature is essential for survival of homeotherms. Brown adipose tissue (BAT) is a specialized fat tissue that is dedicated to thermoregulation1.
Cypess, Aaron M. +9 more
core +1 more source
DIPG-06. PRECLINICAL EVALUATION OF A NOVEL ACVR1 INHIBITOR IN DIFFUSE INTRINSIC PONTINE GLIOMAS
Neuro-Oncology, 2023 Diffuse intrinsic pontine glioma (DIPG) is an incurable brain disease in children. DIPG is refractory to current available therapies. Hence, new therapeutic approaches are urgently needed. About 80% of DIPGs harbor histone 3 lysine to methionine (H3K27M)
S. Kumar +3 more
semanticscholar +1 more source
Fibrodisplasia Osificante Progresiva: Reporte de Primer Caso Guatemalteco
Revista de la Facultad de Medicina, 2023 La Fibrodisplasia Osificante Progresiva (FOP) es una enfermedad rara, compleja, de herencia autosómica dominante, causada por una mutación heterocigota del gen ACVR1 en el cromosoma 2q24 (OMIM 135100), con una prevalencia de 1 en 2 millones en todo el ...
Marcela Elizabeth Orozco Orozco +3 more
doaj +1 more source
Transcriptomic analyses of regenerating adult feathers in chicken [PDF]
, 2015 Transcriptome Expression Data. Table of mapped reads to Galgal4 transcripts for all 15 data sets. FPKM (Fragments per kilobase of exon per million fragments mapped): normalized transcript abundance values for each gene in the indicated tissues.
Chen Siang Ng +16 more
core +6 more sources
Disease Models & Mechanisms, 2016 The ACVR1 gene encodes a type I receptor of bone morphogenetic proteins (BMPs). Activating mutations in ACVR1 are responsible for fibrodysplasia ossificans progressiva (FOP), a rare disease characterized by congenital toe malformation and progressive ...
Serena Cappato +11 more
doaj +1 more source
Journal of Animal Science and Biotechnology, 2021 Background MicroRNAs act as post-transcriptional regulators that repress translation or degrade mRNA transcripts. Each microRNA has many mRNA targets and each mRNA may be targeted by several microRNAs.
Dan Hao +7 more
doaj +1 more source
Neuro-Oncology, 2023 Somatic mutations in ACVR1, which encodes the serine/threonine kinase ALK2, are found in 20-25% of DMG-H3K27 patients. Treatment of ACVR1-mutant orthotopic xenografts with multiple chemotypes of ALK2 inhibitors (ALK2i) results in extended survival in ...
Rebecca F. Rogers +23 more
semanticscholar +1 more source
Atypical Presentation and Management of Fibrodysplasia Ossificans Progressiva [PDF]
, 2017 We report a case of an 18-year-old woman, with bilateral acute inflammatory pain on the hip area, during the premenstrual period, and progressive increase in volume and rigidity of both hips. Bilateral exuberant soft tissue calcifications were present on
Arcângelo, J, Grenho, A, Martins, A
core +1 more source
Disease Models & Mechanisms, 2011 SUMMARY We previously found that lenses lacking the Acvr1 gene, which encodes a bone morphogenetic protein (BMP) receptor, had abnormal proliferation and cell death in epithelial and cortical fiber cells.
Luke A. Wiley +3 more
doaj +1 more source
Genomic Context and Mechanisms of the ACVR1 Mutation in Fibrodysplasia Ossificans Progressiva
Biomedicines, 2021 Basic research in Fibrodysplasia Ossificans Progressiva (FOP) was carried out in the various fields involved in the disease pathophysiology and was important for designing therapeutic approaches, some of which were already developed as ongoing or planned
Roberto Ravazzolo, Renata Bocciardi
doaj +1 more source