Results 11 to 20 of about 28,251 (147)

Central Composite Design for Formulation and Optimization of Solid Lipid Nanoparticles to Enhance Oral Bioavailability of Acyclovir

Molecules, 2021
Treatment of herpes simplex infection requires high and frequent doses of oral acyclovir to attain its maximum therapeutic effect. The current therapeutic regimen of acyclovir is known to cause unwarranted dose-related adverse effects, including acute ...
Haniza Hassan, Siti Khadijah Adam, Ekram Alias, Meor Mohd Redzuan Meor Mohd Affandi, Ahmad Fuad Shamsuddin, Rusliza Basir   +5 more
doaj   +1 more source

Vitreous pharmacokinetics and electroretinographic findings after intravitreal injection of acyclovir in rabbits

Clinics, 2012
OBJECTIVES: Acute retinal necrosis is a rapidly progressive and devastating viral retinitis caused by the herpesvirus family. Systemic acyclovir is the treatment of choice; however, the progression of retinal lesions ceases approximately 2 days after ...
Francisco Max Damico, Mariana Ramos Scolari, Gabriela Lourençon Ioshimoto, Beatriz Sayuri Takahashi, Armando da Silva Cunha Jr., Sílvia Ligório Fialho, Daniela Maria Bonci, Fabio Gasparin, Dora Fix Ventura   +8 more
doaj   +1 more source

Omeprazole Increases the Efficacy of Acyclovir Against Herpes Simplex Virus Type 1 and 2

Frontiers in Microbiology, 2019
Omeprazole was shown to improve the anti-cancer effects of the nucleoside analogue 5-fluorouracil. Here, we combined omeprazole with the antiviral nucleoside analogues ribavirin and acyclovir.
Martin Michaelis, Malte C. Kleinschmidt, Denisa Bojkova, Holger F. Rabenau, Mark N. Wass, Jindrich Cinatl Jr.   +5 more
doaj   +1 more source

Acyclovir Has Low but Detectable Influence on HLA-B*57:01 Specificity without Inducing Hypersensitivity. [PDF]

PLoS ONE, 2015
Immune mediated adverse drug reactions (IM-ADRs) remain a significant source of patient morbidity that have more recently been shown to be associated with specific class I and/or II human leukocyte antigen (HLA) alleles. Abacavir-induced hypersensitivity
Imir G Metushi, Amanda Wriston, Priyanka Banerjee, Bjoern Oliver Gohlke, A Michelle English, Andrew Lucas, Carrie Moore, John Sidney, Soren Buus, David A Ostrov, Simon Mallal, Elizabeth Phillips, Jeffrey Shabanowitz, Donald F Hunt, Robert Preissner, Bjoern Peters   +15 more
doaj   +1 more source

Acyclovir-induced neurotoxicity with a positive cerebrospinal fluid varicella zoster PCR result creating a management dilemma: a case report

Journal of Medical Case Reports, 2020
Background Varicella zoster virus central nervous system infections can present as aseptic meningitis, encephalitis, myelitis, and vasculopathy.
Kelli M. Robertson, Christopher L. Harvey, John M. Cunningham   +2 more
doaj   +1 more source

Pharmacokinetics and analytical determination of acyclovir in Asian elephant calves (Elephas maximus)

Veterinary and Animal Science, 2022
A therapeutic regimen that includes antiviral drugs is critical for the survival of Asian elephant (Elephas maximus) calves infected with elephant endotheliotropic herpesvirus hemorrhagic disease (EEHV-HD), with acyclovir showing considerable promise ...
Siripat Khammesri, Chadarat Ampasavate, Darunee Hongwiset, Raktham Mektrirat, Siriluk Sangsrijan, Janine L. Brown, Chatchote Thitaram   +6 more
doaj   +1 more source

In vitro antiviral activity of thymoquinone and its synergistic effect with acyclovir against herpes simplex virus type 1 (HSV-1) [PDF]

Journal of HerbMed Pharmacology
Introduction: Drug resistance has heightened the demand for natural antiviral agents. Thymoquinone (TQ), a major bioactive component of black seed oil, has demonstrated antiviral activity in numerous studies.
Maryam Shirian, Zainab Jalil Awad Al Jabree, Pegah Khosravian, Masoud Hafizi, Fatemeh Javadi-Farsani, Mohammad-Taghi Moradi   +5 more
doaj   +1 more source

FLUOROMETRIC•DETERMINATION OF ACYCLOVIR IN SPIKED HUMAN PLASMA [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 1993
A highly sensitive fluorometric method for determination of acyclovir  is described. The method depends  on the interaction between acyclovir .and 7-hydroxy-4-methylcoumarin where a fluorophore of high fluorogenic activity is formed which has wavelengths
M. Mabrouk, A. Habeeb
doaj   +1 more source

Acyclovir-Loaded Chitosan Nanospheres from Nano-Emulsion Templating for the Topical Treatment of Herpesviruses Infections

Pharmaceutics, 2018
Acyclovir is not a good candidate for passive permeation since its polarity and solubility limit is partitioning into the stratum corneum. This work aims to develop a new topical formulation for the acyclovir delivery.
Manuela Donalisio, Federica Leone, Andrea Civra, Rita Spagnolo, Ozgen Ozer, David Lembo, Roberta Cavalli   +6 more
doaj   +1 more source

Bullous eruptions in a preschool child: A rare adverse effect of acyclovir

Indian Journal of Paediatric Dermatology, 2020
Acyclovir in children is usually associated with minimal local adverse effects, with bullous eruptions being extremely rare in occurrence. A 5-year-old boy was admitted to the pediatric intensive care unit as a case of febrile encephalopathy with status ...
Nidhi Garg, K V Vinu Balraam
doaj   +1 more source