Results 21 to 30 of about 36,344 (217)

Neonates with acute liver failure have higher overall mortality but similar posttransplant outcomes as older infants

Liver Transplantation, EarlyView., 2022
Abstract Neonatal acute liver failure (ALF) carries a high mortality rate; however, little data exist on its peritransplant hospital course. This project aimed to identify factors associated with outcomes in neonates with ALF using large multicenter databases.
Swati Antala, Bridget Whitehead, Justin Godown, Matt Hall, Anna Banc‐Husu, Estella M. Alonso, Sarah A. Taylor   +6 more
wiley   +1 more source

Acyclovir crystalluria: The utility of bedside urine routine microscopic examination

Journal of Pediatric Critical Care, 2020
Acyclovir, an acyclic nucleoside, is commonly used for the treatment of viral infections. Acyclovir is well tolerated in children. However, severe nephrotoxicity has been shown to occur in some children.
Puneet Jain, Ramachandran Rameshkumar, Ponnarmeni Satheesh, Subramanian Mahadevan   +3 more
doaj   +1 more source

Incidence, patterns, risk factors and clinical outcomes of intravenous acyclovir induced nephrotoxicity

Saudi Pharmaceutical Journal, 2022
Objectives: Acyclovir is approved to treat herpes simplex virus (HSV) type 1, type 2 and varicella-zoster virus. It is mainly eliminated via the kidneys, for which drug crystals accumulation might lead to nephrotoxicity. This study aimed to determine the
Abdullah M. Al-Alawi, Juhaina Salim Al-Maqbali, Maria Al-Adawi, Anan Al-Jabri, Henrik Falhammar   +4 more
doaj   +1 more source

Evaluation of the effects of acyclovir and/or human amniotic membrane on herpes virus culture and quantitative virus inactivity by real-time polymerase chain reaction [PDF]

International Journal of Ophthalmology, 2014
AIM: To investigate the permeability of amniotic membrane in herpes virus cell culture to acyclovir with real time polymerase chain reaction (RT-PCR).METHODS: Madin-Darby Bovine Kidney (MDBK) cell culture and Bovine Herpes Virus (BHV1) type 1 were used ...
Feride Aylin Kantarci, Ali Reza Faraji, Aykut Ozkul, Fikret Akata   +3 more
doaj   +1 more source

Shedding a Light on Acyclovir Pharmacodynamics: A Retrospective Analysis on Pharmacokinetic/Pharmacodynamic Modelling of Acyclovir for the Treatment of Varicella Zoster Virus Infection in Immunocompromised Patients: A Pilot Study

Pharmaceutics, 2022
Background: Acyclovir and valacyclovir are used for the treatment and prophylaxis of infections with herpes simplex virus (HSV) and varicella zoster virus (VZV). The aim of this study is to provide insight into the pharmacodynamics (PD) of (val)acyclovir.
Geeske F. Grit, Anne-Grete Märtson, Marjolein Knoester, Marlous L. Toren-Wielema, Daan J. Touw   +4 more
doaj   +1 more source

Episodic therapy for genital herpes in sub-saharan Africa: a pooled analysis from three randomized controlled trials. [PDF]

, 2011
BACKGROUND: A randomized controlled trial in South Africa found a beneficial effect of acyclovir on genital ulcer healing, but no effect was seen in trials in Ghana, Central African Republic and Malawi.
LeGoff, Jerome, Lewis, David A., Weiss, Helen A, Helen A Weiss, Phiri, Sam, David A Lewis, Hoffman, Irving F, Gerard Gresenguet, Laurent Belec, Pepin, Jacques, William C Miller, Jerome LeGoff, Weiss, Helen A., Sam Phiri, Gabriela Paz Bailey, Miller, William C, David A. Lewis, Paz Bailey, Gabriela, Helen A. Weiss, Irving F Hoffman, Mayaud, Philippe, William C. Miller, Lewis, David A, Philippe Mayaud, Jacques Pepin, Miller, William C., Gresenguet, Gerard, Irving F. Hoffman, Belec, Laurent, Hoffman, Irving F.   +29 more
core   +1 more source

Acyclovir-Loaded Solid Lipid Nanoparticles: Optimization, Characterization and Evaluation of Its Pharmacokinetic Profile

Nanomaterials, 2020
Acyclovir is an antiviral drug used for the treatment of herpes simplex virus infection. Its oral bioavailability is low; therefore, frequent and high doses are prescribed for optimum therapeutic efficacy.
Haniza Hassan, Ramatu Omenesa Bello, Siti Khadijah Adam, Ekram Alias, Meor Mohd Redzuan Meor Mohd Affandi, Ahmad Fuad Shamsuddin, Rusliza Basir   +6 more
doaj   +1 more source

Central Composite Design for Formulation and Optimization of Solid Lipid Nanoparticles to Enhance Oral Bioavailability of Acyclovir

Molecules, 2021
Treatment of herpes simplex infection requires high and frequent doses of oral acyclovir to attain its maximum therapeutic effect. The current therapeutic regimen of acyclovir is known to cause unwarranted dose-related adverse effects, including acute ...
Haniza Hassan, Siti Khadijah Adam, Ekram Alias, Meor Mohd Redzuan Meor Mohd Affandi, Ahmad Fuad Shamsuddin, Rusliza Basir   +5 more
doaj   +1 more source

Acyclovir-induced neurotoxicity in an immunocompromised patient [PDF]

, 2020
This is a case report of a 75-year-old immunocompromised male who developed encephalopathy while undergoing treatment for disseminated herpes zoster with peripheral nerve involvement.
Walston, Bobbi Jo, Marks, Daniel, De La Paz, Andrew   +2 more
core   +1 more source

Vitreous pharmacokinetics and electroretinographic findings after intravitreal injection of acyclovir in rabbits

Clinics, 2012
OBJECTIVES: Acute retinal necrosis is a rapidly progressive and devastating viral retinitis caused by the herpesvirus family. Systemic acyclovir is the treatment of choice; however, the progression of retinal lesions ceases approximately 2 days after ...
Francisco Max Damico, Mariana Ramos Scolari, Gabriela Lourençon Ioshimoto, Beatriz Sayuri Takahashi, Armando da Silva Cunha Jr., Sílvia Ligório Fialho, Daniela Maria Bonci, Fabio Gasparin, Dora Fix Ventura   +8 more
doaj   +1 more source