Results 21 to 30 of about 48,268 (218)

Evaluation of the effects of acyclovir and/or human amniotic membrane on herpes virus culture and quantitative virus inactivity by real-time polymerase chain reaction [PDF]

open access: yesInternational Journal of Ophthalmology, 2014
AIM: To investigate the permeability of amniotic membrane in herpes virus cell culture to acyclovir with real time polymerase chain reaction (RT-PCR).METHODS: Madin-Darby Bovine Kidney (MDBK) cell culture and Bovine Herpes Virus (BHV1) type 1 were used ...
Feride Aylin Kantarci   +3 more
doaj   +1 more source

Acyclovir-Loaded Solid Lipid Nanoparticles: Optimization, Characterization and Evaluation of Its Pharmacokinetic Profile

open access: yesNanomaterials, 2020
Acyclovir is an antiviral drug used for the treatment of herpes simplex virus infection. Its oral bioavailability is low; therefore, frequent and high doses are prescribed for optimum therapeutic efficacy.
Haniza Hassan   +6 more
doaj   +1 more source

Central Composite Design for Formulation and Optimization of Solid Lipid Nanoparticles to Enhance Oral Bioavailability of Acyclovir

open access: yesMolecules, 2021
Treatment of herpes simplex infection requires high and frequent doses of oral acyclovir to attain its maximum therapeutic effect. The current therapeutic regimen of acyclovir is known to cause unwarranted dose-related adverse effects, including acute ...
Haniza Hassan   +5 more
doaj   +1 more source

Herpes simplex keratitis: Challenges in diagnosis and clinical management [PDF]

open access: yes, 2017
Herpes simplex virus is responsible for numerous ocular diseases, the most common of which is herpetic stromal keratitis. This is a recurrent infection of the cornea that typically begins with a subclinical infection of the cornea that establishes a ...
Azher, Tayaba N   +4 more
core   +3 more sources

Vitreous pharmacokinetics and electroretinographic findings after intravitreal injection of acyclovir in rabbits

open access: yesClinics, 2012
OBJECTIVES: Acute retinal necrosis is a rapidly progressive and devastating viral retinitis caused by the herpesvirus family. Systemic acyclovir is the treatment of choice; however, the progression of retinal lesions ceases approximately 2 days after ...
Francisco Max Damico   +8 more
doaj   +1 more source

Clinical features of varicella-zoster virus infection [PDF]

open access: yes, 2018
Varicella-zoster virus (VZV) is a pathogenic human herpes virus that causes varicella (chickenpox) as a primary infection, following which it becomes latent in peripheral ganglia.
Gershon, Anne A., Kennedy, Peter G.E.
core   +1 more source

Acyclovir Has Low but Detectable Influence on HLA-B*57:01 Specificity without Inducing Hypersensitivity. [PDF]

open access: yesPLoS ONE, 2015
Immune mediated adverse drug reactions (IM-ADRs) remain a significant source of patient morbidity that have more recently been shown to be associated with specific class I and/or II human leukocyte antigen (HLA) alleles. Abacavir-induced hypersensitivity
Imir G Metushi   +15 more
doaj   +1 more source

What is Causing This Man\u27s Rectal Pain and Urinary Retention? [PDF]

open access: yes, 2016
Case: A 23-year-old man presented to an urgent care office with a 2-week history of rectal pain and scant rectal bleeding. In the few days leading up to his presentation, he also had a fever of 101° F (38.3° C), inguinal lymphadenopathy, and urinary ...
McKenney-Drake, Mikaela L.   +2 more
core   +2 more sources

Pharmacokinetics and analytical determination of acyclovir in Asian elephant calves (Elephas maximus)

open access: yesVeterinary and Animal Science, 2022
A therapeutic regimen that includes antiviral drugs is critical for the survival of Asian elephant (Elephas maximus) calves infected with elephant endotheliotropic herpesvirus hemorrhagic disease (EEHV-HD), with acyclovir showing considerable promise ...
Siripat Khammesri   +6 more
doaj   +1 more source

Omeprazole Increases the Efficacy of Acyclovir Against Herpes Simplex Virus Type 1 and 2

open access: yesFrontiers in Microbiology, 2019
Omeprazole was shown to improve the anti-cancer effects of the nucleoside analogue 5-fluorouracil. Here, we combined omeprazole with the antiviral nucleoside analogues ribavirin and acyclovir.
Martin Michaelis   +5 more
doaj   +1 more source

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