Results 21 to 30 of about 7,811 (178)

Acyclovir crystalluria: The utility of bedside urine routine microscopic examination

Journal of Pediatric Critical Care, 2020
Acyclovir, an acyclic nucleoside, is commonly used for the treatment of viral infections. Acyclovir is well tolerated in children. However, severe nephrotoxicity has been shown to occur in some children.
Puneet Jain, Ramachandran Rameshkumar, Ponnarmeni Satheesh, Subramanian Mahadevan   +3 more
doaj   +1 more source

Incidence, patterns, risk factors and clinical outcomes of intravenous acyclovir induced nephrotoxicity

Saudi Pharmaceutical Journal, 2022
Objectives: Acyclovir is approved to treat herpes simplex virus (HSV) type 1, type 2 and varicella-zoster virus. It is mainly eliminated via the kidneys, for which drug crystals accumulation might lead to nephrotoxicity. This study aimed to determine the
Abdullah M. Al-Alawi, Juhaina Salim Al-Maqbali, Maria Al-Adawi, Anan Al-Jabri, Henrik Falhammar   +4 more
doaj   +1 more source

Evaluation of the effects of acyclovir and/or human amniotic membrane on herpes virus culture and quantitative virus inactivity by real-time polymerase chain reaction [PDF]

International Journal of Ophthalmology, 2014
AIM: To investigate the permeability of amniotic membrane in herpes virus cell culture to acyclovir with real time polymerase chain reaction (RT-PCR).METHODS: Madin-Darby Bovine Kidney (MDBK) cell culture and Bovine Herpes Virus (BHV1) type 1 were used ...
Feride Aylin Kantarci, Ali Reza Faraji, Aykut Ozkul, Fikret Akata   +3 more
doaj   +1 more source

Shedding a Light on Acyclovir Pharmacodynamics: A Retrospective Analysis on Pharmacokinetic/Pharmacodynamic Modelling of Acyclovir for the Treatment of Varicella Zoster Virus Infection in Immunocompromised Patients: A Pilot Study

Pharmaceutics, 2022
Background: Acyclovir and valacyclovir are used for the treatment and prophylaxis of infections with herpes simplex virus (HSV) and varicella zoster virus (VZV). The aim of this study is to provide insight into the pharmacodynamics (PD) of (val)acyclovir.
Geeske F. Grit, Anne-Grete Märtson, Marjolein Knoester, Marlous L. Toren-Wielema, Daan J. Touw   +4 more
doaj   +1 more source

Episodic therapy for genital herpes in sub-saharan Africa: a pooled analysis from three randomized controlled trials. [PDF]

, 2011
BACKGROUND: A randomized controlled trial in South Africa found a beneficial effect of acyclovir on genital ulcer healing, but no effect was seen in trials in Ghana, Central African Republic and Malawi.
LeGoff, Jerome, Lewis, David A., Weiss, Helen A, Helen A Weiss, Phiri, Sam, David A Lewis, Hoffman, Irving F, Gerard Gresenguet, Laurent Belec, Pepin, Jacques, William C Miller, Jerome LeGoff, Weiss, Helen A., Sam Phiri, Gabriela Paz Bailey, Miller, William C, David A. Lewis, Paz Bailey, Gabriela, Helen A. Weiss, Irving F Hoffman, Mayaud, Philippe, William C. Miller, Lewis, David A, Philippe Mayaud, Jacques Pepin, Miller, William C., Gresenguet, Gerard, Irving F. Hoffman, Belec, Laurent, Hoffman, Irving F.   +29 more
core   +1 more source

Acyclovir-Loaded Solid Lipid Nanoparticles: Optimization, Characterization and Evaluation of Its Pharmacokinetic Profile

Nanomaterials, 2020
Acyclovir is an antiviral drug used for the treatment of herpes simplex virus infection. Its oral bioavailability is low; therefore, frequent and high doses are prescribed for optimum therapeutic efficacy.
Haniza Hassan, Ramatu Omenesa Bello, Siti Khadijah Adam, Ekram Alias, Meor Mohd Redzuan Meor Mohd Affandi, Ahmad Fuad Shamsuddin, Rusliza Basir   +6 more
doaj   +1 more source

Protocol for German trial of Acyclovir and corticosteroids in Herpes-simplex-virus-encephalitis (GACHE) : a multicenter, multinational, randomized, double-blind, placebo-controlled German, Austrian and Dutch trial [ISRCTN45122933] [PDF]

, 2008
Background The treatment of Herpes-simplex-virus-encephalitis (HSVE) remains a major unsolved problem in Neurology. Current gold standard for therapy is acyclovir, a drug that inhibits viral replication.
Menon, Sanjay, Meyding-Lamadé Uta, Luntz, Steffen, Luntz Steffen, Hacke Werner, de Gans, Jan, Eva Schielke, Sanjay Menon, Hacke, Werner, Schielke, Eva, Jensen, Katrin, Meyding-Lamadé, Uta, Schmutzhard Erich, Menon Sanjay, Norbert Victor, Schmutzhard, Erich, Chin-Hee Chung, Victor, Norbert, Jensen Katrin, Martinez-Torres Francisco, Katrin Jensen, Schielke Eva, Maria Pritsch, Jenetzky Ekkehart, Chung Chin-Hee, Pritsch Maria, Martinez Torres, Francisco Javier, Werner Hacke, Erich Schmutzhard, Jenetzky, Ekkehart, Victor Norbert, de Gans Jan, Chung, Chin-Hee, null null, Francisco Martinez-Torres, Steffen Luntz, Uta Meyding-Lamadé, Pritsch, Maria, Martinez-Torres, Francisco, Ekkehart Jenetzky, Jan de Gans   +40 more
core   +2 more sources

Central Composite Design for Formulation and Optimization of Solid Lipid Nanoparticles to Enhance Oral Bioavailability of Acyclovir

Molecules, 2021
Treatment of herpes simplex infection requires high and frequent doses of oral acyclovir to attain its maximum therapeutic effect. The current therapeutic regimen of acyclovir is known to cause unwarranted dose-related adverse effects, including acute ...
Haniza Hassan, Siti Khadijah Adam, Ekram Alias, Meor Mohd Redzuan Meor Mohd Affandi, Ahmad Fuad Shamsuddin, Rusliza Basir   +5 more
doaj   +1 more source

Electrospun Structural Hybrids of Acyclovir-Polyacrylonitrile at Acyclovir for Modifying Drug Release

, 2021
In traditional pharmaceutics, drug–crystalline nanoparticles and drug–polymer composites are frequently explored for their ability to modify drug release profiles.
Yonghui Wu, Shiri Guo, Wanli He, He Lv, Gaoyi Zhang, Deng-Guang Yu   +5 more
core   +1 more source

Comparison of some physical parameters of different brands of acyclovir tablets marketed in Iran: Quality control of acyclovir tablets

, 2022
Acyclovir is the nucleoside analogue of guanosine, which is used as an antiviral drug. Since the quality requirements set for a higher quality product are necessary, the purpose of this study was to investigate the quality control characteristics of ...
Zarepishe, Naeime, Amini, Ali, Tavakoli-Ardakani, Maria, Amidi, Salimeh, Mahboubi-Rabbani, Mohammad   +4 more
core   +1 more source