Results 141 to 150 of about 80,359 (315)

Enhancing the β‐Oxidation‐Like Pathway for the Optimal Production of the Immunosuppressant Mycophenolic Acid

open access: yesAdvanced Science, EarlyView.
The most elaborate known example of β‐oxidation‐like pathway recruitment in fungi is reported, involving a 10‐step oxidative chain‐shortening cascade catalyzed by five dedicated enzymes to generate the pharmacophore of mycophenolic acid (MPA)—a novel clinical immunosuppressant. Our findings illustrate how nature repurposes catabolic enzymes for complex
Baoqiang Fan   +5 more
wiley   +1 more source

Chirality Makes or Breaks Chemically Driven Self‐Assembly

open access: yesAngewandte Chemie, EarlyView.
Chirality‐controlled reaction cycles: Reaction cycles are constructed to respond to the chirality (handedness) of an acylating agent. Left‐ and right‐handed aminoacyl phosphate esters modulate the structure, lifetime, and transformation of transient (thio)ester intermediates, enabling control over distinct chemical pathways using molecules that are ...
Lenard Saile   +5 more
wiley   +2 more sources

Lactate Dehydrogenase C4 Accelerates Triple‐Negative Breast Cancer Progression by Promoting Acetyl‐CoA Acyltransferase 2 Lactylation to Increase Free Fatty Acid Accumulation

open access: yesAdvanced Science, EarlyView.
Diagram of the reprogramming of FA metabolism mediated by LDHC4‐induced ACAA2 activity to promote TNBC progression. LDHC4 drives TNBC progression by enhancing ACAA2‐mediated fatty acid production. The resulting accumulation of FFAs stimulates autophagy and accelerates cell cycle progression, thereby promoting tumor growth.
Zhaolei Cui   +10 more
wiley   +1 more source

Thematic Review Series: Glycerolipids. Acyltransferases in bacterial glycerophospholipid synthesis*

open access: yesJournal of Lipid Research, 2008
Phospholipid biosynthesis is a vital facet of bacterial physiology that begins with the synthesis of the fatty acids by a soluble type II fatty acid synthase.
Yong-Mei Zhang, Charles O. Rock
doaj  

A General Strategy to Fine‐Tune Group 14 Rhodamines for Ultrahigh Signal‐to‐Noise Ratio Labeling In Vivo by Nano‐Aggregation

open access: yesAggregate, EarlyView.
Group 14 rhodamines are one of the most widely explored fluorogenic probes with high signal‐to‐noise ratio (SNR). We have boosted the SNR of group 14 rhodamines by nano‐aggregation via a novel strategy by manipulating their dynamic physical and chemical states for the first time. The ultrahigh SNR fluorescence imaging offers a fundamental understanding
Ning Wang   +5 more
wiley   +1 more source

A Genetically Encoded Homocysteine Precursor to Probe Protein Active Sites and to Addict Escherichia coli to a Noncanonical Amino Acid Directly Involved in Catalysis

open access: yesAngewandte Chemie, EarlyView.
A new genetically encoded amino acid is chemically converted into homocysteine (Hcy) under mild conditions to probe and to activate protein active sites. Surprisingly, Hcy can replace cysteine or serine residues in several enzymes. Its potential for a widespread use in proteins is further underlined by rendering Escherichia coli dependent on Hcy ...
Clara Dunker, Henning D. Mootz
wiley   +2 more sources

Acyl Carrier Protein [PDF]

open access: yesJournal of Biological Chemistry, 1965
Philip W. Majerus   +2 more
openaire   +4 more sources

Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives

open access: yesAggregate, EarlyView.
Triterpenoids serve as both exceptional molecular motifs for supramolecular assembly and versatile therapeutic agents, offering broad biological functions to improve health outcomes and enhance treatment efficacy. This review comprehensively summarizes recent advances in triterpenoid‐based supramolecular systems, including their roles as functional ...
Jie Zhong   +3 more
wiley   +1 more source

Rapid Synthesis and Diversification of Thymine‐Containing Bridged Nucleic Acids Through Cascade Cyclization Reactions

open access: yesAngewandte Chemie, EarlyView.
Several processes are reported that enable the rapid diversification of bridged nucleoside analogues (NAs) starting from a common and readily prepared fluorohydrin. Also, several clinically relevant bridged nucleosides are now prepared in as few as three synthetic steps, creating new opportunities for examining structure‐activity relationships within ...
Cohan Huxley   +7 more
wiley   +2 more sources

Progress in Biomimetic Microdevices for Anticancer Drug Screening and their Potential for Enhancing In Vivo Efficacy

open access: yesAdvanced NanoBiomed Research, EarlyView.
Biomimetic microdevices are redefining anticancer drug screening by mimicking complex tumor microenvironments. This review highlights advances in microfluidic systems, cell microarrays, and in vivo‐like models, offering new insights into drug efficacy prediction and personalized medicine. The development of effective anticancer drugs remains a critical
Ching‐Te Kuo   +2 more
wiley   +1 more source

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