Results 11 to 20 of about 924 (139)

In-Flow Generation of Thionyl Fluoride (SOF2) Enables the Rapid and Efficient Synthesis of Acyl Fluorides from Carboxylic Acids [PDF]

JACS Au
Herein, we report an approach for generating thionyl fluoride (SOF2) from the commodity chemicals thionyl chloride (SOCl2) and potassium fluoride (KF).
Daniele Mazzarella, Jelena Stanić, Miguel Bernús, Arad Seyed Mehdi, Cassandra J. Henderson, Omar Boutureira, Timothy Noël   +6 more
doaj   +6 more sources

Nickel‐Copper‐Catalyzed Hydroacylation of Vinylarenes with Acyl Fluorides and Hydrosilanes [PDF]

Chemistry - A European Journal, 2019
AbstractThe hydroacylation of vinylarenes with acyl fluorides and hydrosilanes was enabled by a synergistic bimetallic Ni/Cu‐catalytic system, giving access to the corresponding branched ketone products. The reaction takes place under mild conditions at 25–80 °C and tolerates base‐sensitive functional groups such as methoxycarbonyl and acetoxy groups.
Tomohiro Iwai, Masaya Sawamura
exaly   +5 more sources

Palladium-Catalyzed Decarbonylative Alkylation of Acyl Fluorides [PDF]

Organic Letters, 2020
Palladium-catalyzed decarbonylative alkylation reactions of acyl fluorides have been developed using alkylboranes having β-hydrogens. A wide range of functional groups were well tolerated, even at the high temperature required for decarbonylation. This protocol provides a diverse C(sp2)-C(sp3) bond formation via a highly efficient decarbonylative ...
Liyan Fu, Qiang Chen, Zhenhua Wang, Yasushi Nishihara   +3 more
core   +6 more sources

Rapid peptide synthesis using a methylimidazolium sulfinyl fluoride salt [PDF]

Communications Chemistry
Peptide couplings have been a subject of investigation for over a century, with modern research seeking to discover new methodologies that minimize purification steps, minimize reagent expense, and/or decrease reaction times.
Joey Lai, Carlota Bahri, Mai P. Truong, Kathleen T. Downey, Glenn M. Sammis   +4 more
doaj   +2 more sources

General alkyl fluoride functionalization via short-lived carbocation-organozincate ion pairs [PDF]

Nature Communications
Fluorinated organic compounds are frequently used across the chemical and life sciences. Although a large, structurally diverse pool of alkyl fluorides is nowadays available, synthetic applications trail behind the widely accepted utility of other ...
D. Lucas Kane, Bryan C. Figula, Kaluvu Balaraman, Jeffery A. Bertke, Christian Wolf   +4 more
doaj   +2 more sources

Nickel-Catalyzed Decarbonylative Thioetherification of Acyl Fluorides via C–F Bond Activation [PDF]

, 2021
Nickel-catalyzed decarbonylative thioetherification of acyl fluorides has been developed. This transformation allows an array of acyl fluorides to react with thiophenols. A wide range of functional groups are well tolerated and the corresponding sulfides
Chen, Qiang, You, Jingwen, Nishihara, Yasushi   +2 more
core   +2 more sources

Photochemical synthesis of acyl fluorides using copper-catalyzed fluorocarbonylation of alkyl iodides

, 2023
Acyl fluorides are important reagents in organic synthesis due to their unique balance between reactivity and stability. Here, we report a copper-catalyzed carbonylative coupling strategy to synthesize acyl fluorides under photoirradiation. Various alkyl
Neal, Mankad, Pinku, Tung
core   +1 more source

Photoinduced N‑Heterocyclic Nitrenium-Catalyzed Single Electron Reduction of Acyl Fluorides for Phenanthridine Synthesis

, 2023
Acyl fluorides are versatile reagents in organic synthesis. However, there is no precedent to employ acyl fluorides as acyl radical precursors. We herein report an N-heterocyclic nitrenium iodide salt-catalyzed photoreduction of acyl fluorides to produce
Xiang-Yu Chen (2226904), Xiang-Yu Chen, Lei Bao (9883), Zhi-Xiang Wang (1489132), Lei Bao, Zhi-Xiang Wang   +5 more
core   +1 more source

Elemental Sulfur-Mediated Transformation of Carboxylic Acids to Acyl Fluorides by Electrophilic Fluorinating Reagent, Selectfluor

, 2023
The elemental sulfur-mediated synthesis of acyl fluorides from carboxylic acids is achieved using Selectfluor. A broad range of acyl fluorides are accessible from carboxylic acids while avoiding the formation of acid anhydrides.
Elsayed M. Mahmoud, Yuji Sumii (1479166), Soichiro Mori, Norio Shibata (1479169), Soichiro Mori (12454923), Norio Shibata, Yuji Sumii, Elsayed M. Mahmoud (15078100)   +7 more
core   +1 more source

Nickel-Catalyzed Decarbonylative Alkynylation of Acyl Fluorides with Terminal Alkynes under Copper-Free Conditions [PDF]

, 2020
Nickel-catalyzed decarbonylative alkynylation of acyl fluorides with terminal silylethynes under copper-free conditions is described. This newly developed method has a wide substrate scope, affording internal silylethynes in moderate to high yields.
Chen, Qiang, Fu, Liyan, You, Jingwen, Nishihara, Yasushi   +3 more
core   +2 more sources