Results 101 to 110 of about 63,314 (347)
Angewandte Chemie International Edition, Accepted Article.Modular megasynthases, such as polyketide synthases (PKSs) and non‐ribosomal peptide synthetases (NRPSs), are molecular assembly lines that biosynthesize many pharmaceutically and ecologically important natural products. Understanding how these compounds evolve could inspire the artificial evolution of compound diversity by metabolic engineering.
Martin Baunach +6 more
wiley +1 more source
Nature Communications, 2016 Endothelial dysfunction is a hallmark of systemic inflammatory response underlying multiple organ failure. Here we report a novel function of DHHC-containing palmitoyl acyltransferases (PATs) in mediating endothelial inflammation.
R. Beard +12 more
semanticscholar +1 more source
Angewandte Chemie International Edition, Accepted Article.Pseudomonas syringae is a soil‐dwelling bacterium that exhibits remarkable niche adaptability and it is known for its devastating impact as a plant pathogen. This bacterium has an outstanding capability to produce a wide array of biologically active natural products. P.
Shuaibing Zhang +7 more
wiley +1 more source
The Plant Cell, 2015 ASAT3 is a trichome-specific BAHD-type acyltransferase that adds aliphatic acyl chains to acylsucroses and contributes to phenotypic diversity of acylsugars among the Solanum tomato species.
Anthony L. Schilmiller +6 more
semanticscholar +1 more source
Marine Drugs, 2013 Lipid A, the hydrophobic anchor of lipopolysaccharide, is an essential component in the outer membrane of most Gram-negative bacteria. Food-borne pathogen Cronobacter sakazakii synthesizes two lipid A species, differing by the length of the secondary ...
Wen Guo +5 more
doaj +1 more source
Frontiers in Plant Science, 2020 Camelina sativa is an emerging biotechnology oil crop. However, more information is needed regarding its innate lipid enzyme specificities. We have therefore characterized several triacylglycerol (TAG) producing enzymes by measuring in vitro substrate ...
Ida Lager +7 more
doaj +1 more source
Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase
Nature Communications, 2015 Lysosomal phospholipase A2 (LPLA2) and lecithin:cholesterol acyltransferase (LCAT) belong to a structurally uncharacterized family of key lipid-metabolizing enzymes responsible for lung surfactant catabolism and for reverse cholesterol transport ...
A. Glukhova +5 more
semanticscholar +1 more source
Identification of an SCPL Gene Controlling Anthocyanin Acylation in Carrot (Daucus carota L.) Root
Frontiers in Plant Science, 2020 Anthocyanins are natural health promoting pigments that can be produced in large quantities in some purple carrot cultivars. Decoration patterns of anthocyanins, such as acylation, can greatly influence their stability and biological properties and use ...
Julien Curaba +11 more
doaj +1 more source
An Update: Enzymatic Synthesis for Industrial Applications
Angewandte Chemie International Edition, Accepted Article.Supported by rapid technological advancements, biocatalytic applications have matured into a sustainable, scalable, and cost‐competitive alternatives to established chemical catalysis. This review presents the most recent examples of enzyme‐based solutions for the manufacturing of molecules with extended carbon‐carbon frameworks and multiple ...
Thomas Bayer +4 more
wiley +1 more source
Determinants of pH profile and acyl chain selectivity in lysosomal phospholipase A2 [S]
Journal of Lipid Research, 2018 Lysosomal phospholipase A2 (LPLA2) is characterized by broad substrate recognition, peak activity at acidic pH, and the transacylation of lipophilic alcohols, especially N-acetyl-sphingosine. Prior structural analysis of LPLA2 revealed the presence of an
Vania Hinkovska-Galcheva +7 more
doaj