Results 91 to 100 of about 58,529 (305)

Mining the active proteome of Arabidopsis thaliana

Frontiers in Plant Science, 2011
Assigning functions to the >30.000 proteins encoded by the Arabidopsis genome is a challenging task of the Arabidopsis Functional Genomics Network.
Renier A. L. Van Der Hoorn, Tom eColby, Sabrina eNickel, Kerstin eRichau, Juergen eSchmidt, Markus eKaiser   +5 more
doaj   +1 more source

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

Advanced Science, EarlyView.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak, Juliane Tschuck, Stefanie A. I. Weiß, Daniel Kaemena, Karolin Klimm, Ana Galhoz, Larissa Ringelstetter, Myles Fennell, Juliane Merl‐Pham, Anna Artati, Stefanie Strasser, Ralph Garippa, Michael Witting, Hans Zischka, Joel A. Schick, Stefanie M. Hauck, Michael P. Menden, Michelle Vincendeau, Brent R. Stockwell, Kamyar Hadian   +19 more
wiley   +1 more source

Enzymatic characterization of a human acyltransferase activity.

, 2009
Non-histone protein acylation is increasingly recognized as an important posttranslational modification, but little is known as to the biochemical properties of protein serine acylating enzymes.We here report that we have identified a metal-stimulated ...
Iris Lindberg, Richard B Speaker, Akihiko Ozawa   +2 more
core   +1 more source

Structure of the Acyl-[acyl-carrier-protein]—UDP-N acetyl glucosamine O-acyltransferase protein.

, 2021
(A) Three dimensional structure of Acyl-[acyl-carrier-protein]—UDP-N acetyl glucosamine O-acyltransferase protein. (B) Ramachandran Plot of Acyl-[acyl-carrier-protein]—UDP-N acetyl glucosamine O-acyltransferase protein.
Ijaz Rasul (11841071), Usman Ali Ashfaq (9386004), Habibullah Nadeem (1980106), Muhammad Zubair (728141), Hira Saleem (11841068), Muhammad Hussnain Siddique (8966621)   +5 more
core   +1 more source

Silencing AT3 gene reduces the expression of pAmt, BCAT, Kas, and Acl genes involved in capsaicinoid biosynthesis in chili pepper fruits

Biologia Plantarum, 2015
The effects of AT3-gene silencing on the expression of genes involved in capsaicinoid biosynthesis was investigated in chili pepper (Capsicum annuum L.) cv. Tampiqueño 74 fruits.
M. L. Arce-Rodríguez, N. Ochoa-Alejo
doaj   +1 more source

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria[S]

Journal of Lipid Research, 2011
The enzyme 1-acylglycerol-3-phosphate-O-acyltransferase (AGPAT) converts lysophosphatidic acid (LPA) to phosphatidic acid (PA). In this study, we show enzymatic properties, tissue distribution, and subcellular localization of human AGPAT3 and AGPAT5.
Sneha S. Prasad, Abhimanyu Garg, Anil K. Agarwal   +2 more
doaj   +1 more source

Microsomal glycerolphosphate acyltransferase inactivation by fatty acids

, 1990
Glycerolphosphate acyltransferase activity in microsomes from rat adipose tissue is shown to decrease with time upon incubation with adipose tissue cytosolic fraction.
M. A. Rodriguez, V. Durocher, M. Miller
core   +1 more source

Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity

Journal of Lipid Research, 2006
Triglyceride synthesis in most mammalian tissues involves the sequential addition of fatty acids to a glycerol backbone, with unique enzymes required to catalyze each acylation step.
Laurent Vergnes, Anne P. Beigneux, Ryan Davis, Steven M. Watkins, Stephen G. Young, Karen Reue   +5 more
doaj   +1 more source

Transcriptome Analysis Reveals Candidate Genes Related to Anthocyanin Biosynthesis in Different Carrot Genotypes and Tissues

Plants, 2020
Black carrots are characterized by a significant amount of anthocyanins, which are not only a good source of natural food colorant, but can also provide many health benefits to humans. In the present work, taproots of different carrot genotypes were used
Geng Meng, Sabine K. Clausen, Søren K. Rasmussen   +2 more
doaj   +1 more source