Results 71 to 80 of about 58,776 (313)

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Suppression of a BAHD acyltransferase decreases p-coumaroyl on arabinoxylan and improves biomass digestibility in the model grass Setaria viridis [PDF]

, 2020
Grass cell walls have hydroxycinnamic acids attached to arabinosyl residues of arabinoxylan (AX), and certain BAHD acyltransferases are involved in their addition.
Sampaio, B. L., Marchiosi, R., Campanha, R. B., Mota, T. R., De Souza, W. R., Ribeiro, A. P., Vieriea, D. S., Martins, P. K., Duarte, K. E., Oliveira, D. M., Vinecky, F., Dos Santos, W. D., Pacheco, T. F., De K. V. Monteiro, N., Molinari, H. B., Kobayashi, A. K., Ferrarese-Filho, O., De O Molinari, P. A., Mitchell, R. A. C.   +18 more
core   +1 more source

The Role of Acyl-Glucose in Anthocyanin Modifications

Molecules, 2014
Higher plants can produce a wide variety of anthocyanin molecules through modification of the six common anthocyanin aglycons that they present. Thus, hydrophilic anthocyanin molecules can be formed and stabilized by glycosylation and acylation.
Nobuhiro Sasaki, Yuzo Nishizaki, Yoshihiro Ozeki, Taira Miyahara   +3 more
doaj   +1 more source

Stage‐Specific H3K14 and H3K23 Succinylation Orchestrates Insect Metamorphosis and Oogenesis

Advanced Science, EarlyView.
Stage‐specific succinylation of histone H3 at lysine 14 and 23 differentially controls insect metamorphosis and oogenesis through distinct GPCR‐PKC signaling cascades, revealing an evolutionarily conserved epigenetic mechanism that coordinates key life‐history traits.
Yu‐Pu Jing, Lunjie Li, Libin Yang, Lin‐Jie Zhang, Qiang Yan, Ci Zhang, Zanrong Wen, Guangze Yu, Qian Li, Shutang Zhou   +9 more
wiley   +1 more source

The membrane bound phosphatidic add phosphatase from avocado [PDF]

, 1997
Phosphatidate Phosphatase (EC 3.1.3.4) is an important enzyme in plant lipid metabolism as it lies at a theoretical branchpoint between phospholipid and triacylglycerol biosyntheses.
Pearce, Matthew L., Pearce, M.L.
core  

Sequence‐Based Prediction of Promiscuous Acyltransferase Activity in Hydrolases [PDF]

, 2020
Certain hydrolases preferentially catalyze acyl transfer over hydrolysis in an aqueous environment. However, the molecular and structural reasons for this phenomenon are still unclear.
Lammers, M., Lukas Reisky, Simon P. Godehard, Palm, G.J., Badenhorst, C.P.S., Badenhorst, Christoffel P. S., Bornscheuer, U.T., Godehard, Simon P., Gottfried J. Palm, Müller, Henrik, Christoffel P. S. Badenhorst, Müller, H., Palm, Gottfried J., Ann‐Kristin Becker, Reisky, Lukas, Reisky, L., Becker, A.K., Godehard, S.P., Lammers, Michael, Henrik Müller, Becker, Ann‐Kristin, Leona Berndt, Berndt, Leona, Bornscheuer, Uwe T., Uwe T. Bornscheuer, Berndt, L., Michael Lammers   +26 more
core   +1 more source

Short-chain fatty acids activate acetyltransferase p300

eLife, 2021
Short-chain fatty acids (SCFAs) acetate, propionate, and butyrate are produced in large quantities by the gut microbiome and contribute to a wide array of physiological processes. While the underlying mechanisms are largely unknown, many effects of SCFAs
Sydney P Thomas, John M Denu
doaj   +1 more source

Amplification of Endoplasmic Reticulum Stress via Inhibiting Lipid Droplet Formation to Enhance Chemodynamic Immunotherapy

Advanced Science, EarlyView.
An endoplasmic reticulum (ER)‐targeted chemodynamic nanoagent (TCBQ/iLD‐ER NPs) comprising •OH‐generating tetrachloro‐1,4‐benzoquinone (TCBQ) and lipid droplets (LDs) formation inhibitor (iLD) is developed for chemodynamic immunotherapy of tumors. After ingestion by cancer cells, TCBQ/iLD‐ER NPs preferentially accumulate in the ER and react with ER ...
Huilan Cai, Shaoru Zhuang, Yang Zhu, Rujiang Ao, Meili Yu, Tingting Cui, Jun Wang, Xuegang Niu, Hongwei Huang, Shanshan Peng, Yu He, Lisen Lin, Huanghao Yang   +12 more
wiley   +1 more source

Purification of Dihydroxyacetone Phosphate Acyltransferase from Guinea Pig Liver Peroxisomes [PDF]

, 1993
Dihydroxyacetone phosphate acyltransferase (EC 2.3.1.42), a peroxisomal enzyme which initiates the biosynthesis of glycerolipids (especially the ether-linked glycerolipids) in higher eukaryotes, has been purified by over 3250-fold from guinea pig liver ...
Webber K. O. ,, Hajra A. K. ,
core   +1 more source

Membrane Topology of Hedgehog Acyltransferase [PDF]

Journal of Biological Chemistry, 2015
Hedgehog acyltransferase (Hhat) is a multipass transmembrane enzyme that mediates the covalent attachment of the 16-carbon fatty acid palmitate to the N-terminal cysteine of Sonic Hedgehog (Shh). Palmitoylation of Shh by Hhat is critical for short and long range signaling.
Armine, Matevossian, Marilyn D, Resh
openaire   +2 more sources