Results 81 to 90 of about 58,776 (313)
Advanced Science, EarlyView.ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang +9 more
wiley +1 more source
Angewandte Chemie, EarlyView.The fischerazoles, unusual cyanobacterial chlorinated lipopeptides are reported. During their biosynthesis, a linear fatty acyl‐acyl carrier protein (ACP) precursor is rearranged through the action of the S‐adenosyl‐methionine (SAM)‐dependent methyltransferase FshF, to generate a pendant vinyl group.
Sandra A. C. Figueiredo +8 more
wiley +2 more sources
Studies of dihydroxyacetone phosphate acyltransferase. [PDF]
, 1988 Acyl-coenzyme A:dihydroxyacetone phosphate acyltransferase (EC 2.3.1.42) is the enzyme which initiates the biosynthesis of both the ester-linked and the ether-linked glycerolipids.
Webber, Keith Owen
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Lecithin:cholesterol acyltransferase and vascular disease [PDF]
, 2010 Evaluation of: Calabresi L, Baldassarre D, Castelnuovo S et al.: Functional lecithin:cholesterol acyltransferase is not required for efficient atheroprotection in humans. Circulation 120, 628-635 (2009).
A.L. Catapano, G.D. Norata
core +1 more source
MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes
Advanced Science, EarlyView.A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak +19 more
wiley +1 more source
Characterisation of monolysocardiolipin acyltransferase activity [PDF]
, 2000 Cardiolipin (CL) is a unique phospholipid synthesised exclusively in the mitochondria where it is also mainly localised. Monolyso-CL acyltransferase is the enzyme responsible for re-acylating monolyso-CL to CL once a phospholipase A has removed one of ...
Ma, Brian Jason Lap-Yen
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Acyltransferase Mediated Polyketide Release from a Fungal Megasynthase [PDF]
, 2016 Acyltransferase Mediated Polyketide Release from a Fungal ...
Yi Tang (55726) +4 more
core +1 more source
Catalytic properties of MGAT3, a putative triacylgycerol synthases⃞
Journal of Lipid Research, 2007 Acyl-coenzyme A:monoacylglycerol acyltransferase 3 (MGAT3) is a member of the MGAT family of enzymes that catalyze the synthesis of diacylglycerol (DAG) from monoacylglycerol (MAG), a committed step in dietary fat absorption.
Jingsong Cao, Long Cheng, Yuguang Shi
doaj +1 more source
Advanced Science, EarlyView.This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai +12 more
wiley +1 more source
Inhibition of ghrelin o-acyltransferase attenuated lipotoxicity by inducing autophagy via AMPK–mTOR pathway [PDF]
, 2018 Shaoren Zhang, Yuqing Mao, Xiaoming Fan Department of Gastroenterology and Hepatology, Jinshan Hospital of Fudan University, Shanghai, China Background: Nonalcoholic fatty liver disease (NAFLD) has been considered the most commonly occurring chronic ...
Fan X, Zhang S, Mao Y
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