Results 41 to 50 of about 63,314 (347)
In Vitro Analysis of Hedgehog Acyltransferase and Porcupine Fatty Acyltransferase Activities [PDF]
, 2019 Hedgehog and Wnt proteins are modified by covalent attachment of the fatty acids palmitate and palmitoleate, respectively. These lipid modifications are essential for Hedgehog and Wnt protein signaling activities and are catalyzed by related, but distinct fatty acyltransferases: Hedgehog acyltransferase (Hedgehog) and Porcupine (Wnt).
James J. Asciolla +4 more
openaire +2 more sources
Cancer Medicine, Volume 11, Issue 24, Page 5050-5065, December 2022., 2022 The aberrant expression pattern and prognostic implications of HIVEP3 in AML were explored and validated based on versatile bioinformatics tools. A LASSO model which combined HIVEP3 with ferroptosis regulators was created to predict the prognosis for AML patients.
Xiaoning Zhang +6 more
wiley +1 more source
Evolutionary Developments in Plant Specialized Metabolism, Exemplified by Two Transferase Families
Frontiers in Plant Science, 2019 Plant specialized metabolism emerged from the land colonization by ancient plants, becoming diversified along with plant evolution. To date, more than 1 million metabolites have been predicted to exist in the plant kingdom, and their metabolic processes ...
Hiroaki Kusano +5 more
doaj +1 more source
Microorganisms, 2021 Biocatalytic transesterification is commonly carried out employing lipases in anhydrous organic solvents since hydrolases usually prefer hydrolysis over acyl transfer in bulk water.
Amanda Staudt +7 more
doaj +1 more source
ChemBioChem, Volume 23, Issue 23, December 5, 2022., 2022 Housing sulfur: Certain fungi produce diketopiperazine compounds with a transannular sulfur bridge. These so‐called epipolythiodioxopiperzines are toxic by non‐specifically interacting with intracellular proteins and contribute to fungal pathogenicity. Producer strains serve as bio‐pesticides but also question safety of food fermentation.
Eva M. Huber
wiley +1 more source
Expression of mouse MGAT in Arabidopsis results in increased lipid accumulation in seeds
Frontiers in Plant Science, 2015 Worldwide demand for vegetable oil is projected to double within the next thirty years due to increasing food, fuel and industrial requirements. There is therefore great interest in metabolic engineering strategies that boost oil accumulation in plant ...
Anna eEl Tahchy +9 more
doaj +1 more source
Molecules, 2021 Taxol is one of the most effective anticancer drugs in the world that is widely used in the treatments of breast, lung and ovarian cancer. The elucidation of the taxol biosynthetic pathway is the key to solve the problem of taxol supply.
Tao Wang +6 more
doaj +1 more source
Automated structure prediction of trans-acyltransferase polyketide synthase products
Nature Chemical Biology, 2019 Bacterial trans-acyltransferase polyketide synthases (trans-AT PKSs) are among the most complex known enzymes from secondary metabolism and are responsible for the biosynthesis of highly diverse bioactive polyketides.
Eric J. N. Helfrich +11 more
semanticscholar +1 more source
Targeting diacylglycerol acyltransferase 2 for the treatment of nonalcoholic steatohepatitis
Science Translational Medicine, 2019 Inhibition of DGAT2 reduces steatosis, inflammation, and fibrosis in rodent models of NASH and reduces liver fat in clinical testing. A pill a day keeps liver fat away Nonalcoholic fatty liver diseases can progress to liver failure but currently lack ...
N. Amin +8 more
semanticscholar +1 more source
Frontiers in Plant Science, 2020 Tea (Camellia sinensis L.) leaves synthesize and concentrate a vast array of galloylated catechins (e.g., EGCG and ECG) and non-galloylated catechins (e.g., EGC, catechin, and epicatechin), together constituting 8%–24% of the dry leaf mass.
Muhammad Zulfiqar Ahmad +6 more
doaj +1 more source