Results 41 to 50 of about 58,776 (313)

Alcohol acyltransferases for the biosynthesis of esters

Biotechnology for Biofuels and Bioproducts, 2023
AbstractEsters are widely used in food, energy, spices, chemical industry, etc., becoming an indispensable part of life. However, their production heavily relies on the fossil energy industry, which presents significant challenges associated with energy shortages and environmental pollution. Consequently, there is an urgent need to identify alternative
Gaofei Liu, Lei Huang, Jiazhang Lian
openaire   +3 more sources

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis

Hepatology, EarlyView., 2022
Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres, Cristina Ortiz, Nadine Bachtler, Wenyi Gu, Leon D. Grünewald, Nico Kraus, Robert Schierwagen, Christoph Hieber, Caroline Meier, Olaf Tyc, Maximilian Joseph Brol, Frank Erhard Uschner, Bart Nijmeijer, Christoph Welsch, Marie‐Luise Berres, Carmen Garcia‐Ruiz, Jose Carlos Fernandez‐Checa, Christian Trautwein, Thomas J. Vogl, Stefan Zeuzem, Jonel Trebicka, Sabine Klein   +21 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Biochemical studies on plant glycerol-3- phosphate acyltransferase [PDF]

, 2003
sn-Glycerol-3-phosphate acyltransferase [G3PAT, PlsB (E.coli), EC 2.3.1.15] is an enzyme involved in glycerolipid biosynthesis, catalysing the acylation of glycerol-3-phosphate (G3P) to produce lysophosphatidic acid (LPA). Chilling tolerance in plants is
Hayman, Matthew William
core  

Genomic features of carnitine acyltransferase genes. [PDF]

, 2015
Genomic features of carnitine acyltransferase genes.
Amirthagowri Ambalavanan (651834), Pingxing Xie (290131), Ousmane Diallo (651835), Cynthia V. Bourassa (357744), Dan Spiegelman (229081), Edouard Henrion (229084), Sirui Zhou (744860), Alexandre Dionne-Laporte (651836), Maude Turcotte Gauthier (744861), Patrick A. Dion (105550), Lan Xiong (213879), Guy A. Rouleau (105556)   +11 more
core   +1 more source

Structure, mechanism, and inhibition of Hedgehog acyltransferase [PDF]

, 2021
The Sonic Hedgehog (SHH) morphogen pathway is fundamental for embryonic development and stem cell maintenance and is implicated in various cancers. A key step in signaling is transfer of a palmitate group to the SHH N terminus, catalyzed by the multi ...
Siebold, Christian, Pardon, Els, Tate, Edward W, Steyaert, Jan, Ansell, T Bertie, Andrei, Sebastian A, Coupland, Claire E, Sansom, Mark SP, Carrique, Loic, Sefer, Lea, Schwab, Rebekka A, Kumar, Pramod, Lanyon-Hogg, Thomas, Magee, Anthony I, Magee, Anthony, Byrne, Eamon FX   +15 more
core   +1 more source

Functional diversity of sunflower DGAT1 and DGAT2 enzymes underlying seed triacylglycerol biosynthesis

Frontiers in Plant Science
IntroductionTriacylglycerols (TAGs) are the main storage lipids in oilseeds, providing energy and carbon during seed germination, and serving as valuable feedstocks for food, feed, and industrial applications.
Mónica Villoslada-Valbuena, Juan Diego Fernández-García, Juan Ramón Maroto-García, Raquel Martíns Noguerol, Smita Kurup, Enrique Martínez-Force, Joaquín J. Salas, Mónica Venegas-Calerón   +7 more
doaj   +1 more source

The zDHHC family of S-acyltransferases [PDF]

Biochemical Society Transactions, 2015
The discovery of the zDHHC family of S-acyltransferase enzymes has been one of the major breakthroughs in the S-acylation field. Now, more than a decade since their discovery, major questions centre on profiling the substrates of individual zDHHC enzymes (there are 24 ZDHHC genes and several hundred S-acylated proteins), defining the mechanisms of ...
Lemonidis, Kimon, Werno, Martin W., Greaves, Jennifer, Diez Ardanuy, Cinta, Sanchez Perez, Maria C., Salaun, Christine, Thomson, David M., Chamberlain, Luke H.   +7 more
openaire   +4 more sources