Results 11 to 20 of about 17,541 (293)
Local and substrate-specific S-palmitoylation determines subcellular localization of Gαo
Nature Communications, 2022 How palmitoylated proteins specifically localize is not fully understood. Here, authors created the SwissKASH assay to visualize S-palmitoylation in cells and uncovered a striking substrate selectivity of acyltransferases at the core of this process.
Gonzalo P. Solis +6 more
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Regulation of T cell function by protein S-acylation
Frontiers in Physiology, 2022 S-acylation, the reversible lipidation of free cysteine residues with long-chain fatty acids, is a highly dynamic post-translational protein modification that has recently emerged as an important regulator of the T cell function. The reversible nature of
Savannah J. West +4 more
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Intestinal triacylglycerol synthesis in fat absorption and systemic energy metabolism
Journal of Lipid Research, 2015 The intestine plays a prominent role in the biosynthesis of triacylglycerol (triglyceride; TAG). Digested dietary TAG is repackaged in the intestine to form the hydrophobic core of chylomicrons, which deliver metabolic fuels, essential fatty acids, and ...
Chi-Liang Eric Yen +2 more
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MOGAT2: A New Therapeutic Target for Metabolic Syndrome
Diseases, 2015 Metabolic syndrome is an ever-increasing health problem among the world’s population. It is a group of intertwined maladies that includes obesity, hypertriglyceridemia, hypertension, nonalcoholic fatty liver disease (NAFLD), and diabetes mellitus type II
Muhua Yang, Joseph T. Nickels
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Acyltransferases as Tools for Polyketide Synthase Engineering
Antibiotics, 2018 Polyketides belong to the most valuable natural products, including diverse bioactive compounds, such as antibiotics, anticancer drugs, antifungal agents, immunosuppressants and others.
Ewa Maria Musiol-Kroll +1 more
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Nature Communications, 2022 Approaches for manipulating individual organelles are important for learning more about their functions. Here the authors report a tool utilising phospholipase A/acyltransferases (PLAATs) for rapid defunctionalisation of organelles through remodelling of
Satoshi Watanabe +6 more
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Journal of Lipid Research, 1971 Isolated mitochondria cannot synthesize their own phospholipids, there is only an exchange between exogenous and mitochondrial phospholipid fatty acids.
MARIE-THÉRÈSE SAUNER, MARIANNE LÉVY
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Marine Drugs, 2013 The importance of n-3 long chain polyunsaturated fatty acids (LC-PUFAs) for human health has received more focus the last decades, and the global consumption of n-3 LC-PUFA has increased.
Alice Mühlroth +7 more
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Alcohol acyltransferases for the biosynthesis of esters
Biotechnology for Biofuels and Bioproducts, 2023 Esters are widely used in food, energy, spices, chemical industry, etc., becoming an indispensable part of life. However, their production heavily relies on the fossil energy industry, which presents significant challenges associated with energy ...
Gaofei Liu, Lei Huang, Jiazhang Lian
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Identification and characterization of piperine synthase from black pepper, Piper nigrum L.
Communications Biology, 2021 Schnabel et al. identify and characterize piperine synthase in developing black pepper fruits which catalyses the formation of piperine from piperoyl coenzyme A and piperidine.
Arianne Schnabel +5 more
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