Results 11 to 20 of about 32,557 (330)

Mitochondrial acyltransferases and glycerophospholipid metabolism.

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2017
Our understanding of the synthesis and remodeling of mitochondrial phospholipids remains incomplete. Two isoforms of glycerol-3-phosphate acyltransferase (GPAT1 and 2) and two isoforms of acylglycerol-3-phosphate acyltransferase (AGPAT4 and 5) are located on the outer mitochondrial membrane, suggesting that both lysophosphatidic acid and phosphatidic ...
M. Gonzalez-Baro, R. Coleman
semanticscholar   +4 more sources

Genome-wide identification of BAHD acyltransferases and in vivo characterization of HQT-like enzymes involved in caffeoylquinic acid synthesis in globe artichoke

Frontiers in Plant Science, 2016
Globe artichoke (Cynara cardunculus L. var. scolymus) is a rich source of compounds promoting human health (phytonutrients), among them caffeoylquinic acids (CQAs), mainly represented by chlorogenic acid (CGA), and dicaffeoylquinic acids (diCQAs).
Andrea Moglia, Alberto Acquadro, Kaouthar Eljounaidi, Anna Maria Milani, Cecilia Cagliero, Patrizia Rubiolo, Andrea Genre, Katarina Cankar, Jules Beekwilder, Cinzia Comino   +9 more
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Synthesis of neutral ether lipid monoalkyl-diacylglycerol by lipid acyltransferases[S]

Journal of Lipid Research, 2017
In mammals, ether lipids exert a wide spectrum of signaling and structural functions, such as stimulation of immune responses, anti-tumor activities, and enhancement of sperm functions.
Zhengping Ma, Joelle M. Onorato, Luping Chen, David W. Nelson, Chi-Liang Eric Yen, Dong Cheng   +5 more
doaj   +2 more sources

Insights into acylation mechanisms: co‐expression of serine carboxypeptidase‐like acyltransferases and their non‐catalytic companion paralogs

The Plant Journal, 2022
SUMMARY Serine carboxypeptidase‐like acyltransferases (SCPL‐ATs) play a vital role in the diversification of plant metabolites. Galloylated flavan‐3‐ols highly accumulate in tea (Camellia sinensis), grape (Vitis vinifera), and persimmon (Diospyros kaki).
Shengbo Yao, Ya-Jun Liu, Juhua Zhuang, Yue Zhao, Xinlong Dai, Changjuan Jiang, Zhihui Wang, Xiaolan Jiang, Shuxiang Zhang, Yumei Qian, Yuling Tai, Yunsheng Wang, Haiyan Wang, D. Xie, Liping Gao, Tao Xia   +15 more
semanticscholar   +1 more source

Lipid Metabolism in Cancer: The Role of Acylglycerolphosphate Acyltransferases (AGPATs)

Cancers, 2022
Simple Summary Rapidly proliferating cancer cells reprogram lipid metabolism to keep the balance between fatty acid uptake, synthesis, consumption, and storage as triacylglycerides (TAG).
Angeliki Karagiota, G. Chachami, E. Paraskeva   +2 more
semanticscholar   +1 more source

Substrate promiscuity of acyltransferases contributes to the diversity of hydroxycinnamic acid derivatives in purple coneflower.

The Plant Journal, 2022
Hydroxycinnamic acid derivatives (HADs) represented by chicoric acid are the main active ingredients of purple coneflower (Echinacea purpurea (L.) Moench).
Rao Fu, Pingyu Zhang, Ge Jin, Shuo Wei, Jiang Chen, J. Pei, Yang Zhang   +6 more
semanticscholar   +1 more source

Acyltransferases in Bacteria [PDF]

Microbiology and Molecular Biology Reviews, 2013
SUMMARY Long-chain-length hydrophobic acyl residues play a vital role in a multitude of essential biological structures and processes. They build the inner hydrophobic layers of biological membranes, are converted to intracellular storage compounds, and are used to modify protein properties or function as membrane anchors, to name only a few ...
Alexander Steinbüchel, Alexander Steinbüchel, Annika Röttig   +2 more
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Recent Research Progress in Taxol Biosynthetic Pathway and Acylation Reactions Mediated by Taxus Acyltransferases

Molecules, 2021
s Taxol is one of the most effective anticancer drugs in the world that is widely used in the treatments of breast, lung and ovarian cancer. The elucidation of the taxol biosynthetic pathway is the key to solve the problem of taxol supply.
Tao Wang, Lingyu Li, W. Zhuang, Fengjiao Zhang, Xiao-chun Shu, Ning Wang, Zhong Wang   +6 more
semanticscholar   +1 more source

The zDHHC family of S-acyltransferases [PDF]

Biochemical Society Transactions, 2015
The discovery of the zDHHC family of S-acyltransferase enzymes has been one of the major breakthroughs in the S-acylation field. Now, more than a decade since their discovery, major questions centre on profiling the substrates of individual zDHHC enzymes (there are 24 ZDHHC genes and several hundred S-acylated proteins), defining the mechanisms of ...
Lemonidis, Kimon, Werno, Martin W., Greaves, Jennifer, Diez Ardanuy, Cinta, Sanchez Perez, Maria C., Salaun, Christine, Thomson, David M., Chamberlain, Luke H.   +7 more
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Open Biology: overview for special issue on dynamics of protein fatty acylation

Open Biology, 2021
Fatty acylation is a widespread form of protein modification that occurs on specific intracellular and secreted proteins. Beyond increasing hydrophobicity and the affinity of the modified protein for lipid bilayers, covalent attachment of a fatty acid ...
Marilyn D. Resh
doaj   +1 more source