Results 241 to 250 of about 17,541 (293)

Stereochemische Entschlüsselung der Strobilurin‐PKS enthüllt die komplexe biosynthetische Logik des iterativen Aufbaus eines EZE‐Triens

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
Die iterative Strobilurin‐PKS baut ein bemerkenswertes EZE‐Trien auf, indem es seine S‐tereoselektvität während der Synthese variiert. Die stereoselektive 2R‐Methylierung des Triketid‐Intermediats durch die C‐terminale C‐Methyltransferase‐Domäne induziert die KR‐ und DH‐Domänen ihre native Stereoselektivität umzukehren und ein Z‐konfiguriertes ...
Maurice Hauser, Jing Pang, Daowan Lai, Yunlong Sun, Hao Yao, Russell J. Cox   +5 more
wiley   +1 more source

Engineering galactoside acetyltransferase for enhanced hesperetin-7-O-glucoside bioavailability. [PDF]

Appl Microbiol Biotechnol
Wang JX, Lin ZF, Zheng XY, Zhou JL, Huang JJ, Lu YJ.   +5 more
europepmc   +1 more source

Pseudotetraivprolides from Pseudomonas entomophila Provide Insights into the Biosynthesis of Detoxin/Rimosamide‐Like Anti‐Antibiotics

Angewandte Chemie International Edition, Volume 65, Issue 4, 22 January 2026.
Pseudotetraivprolide is a new player among the Detoxin/Rimosamide‐like natural products! Its biosynthesis requires FabD from primary metabolism and a PipDFG complex for final‐step acetylation – unlocking its anti‐antibotic activity. Abstract Novel variants of known natural product (NP) classes can provide valuable insights into their biosynthesis ...
Edna Bode, Julia Büllesbach, Kevin Bauer, Yan‐Ni Shi, Simon Reiners, Ziheng Cui, Petra Happel, Yi‐Ming Shi, Kevin Hoffmann, Peter Grün, Bianca Pommerenke, Uli Kazmaier, Martin Grininger, Helge B. Bode   +13 more
wiley   +1 more source

Phylogenomic and synteny analysis of BAHD and SCP/SCPL gene families reveal their evolutionary histories in plant specialized metabolism. [PDF]

Philos Trans R Soc Lond B Biol Sci
Naake T, D'Auria JC, Fernie AR, Scossa F.   +3 more
europepmc   +1 more source

Proximal Tubule‐Specific Genetic Deficiency of PPARα Worsens Systemic Lipid and Glucose Metabolism During Fasting

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Proximal tubule‐specific PPARα knockout mouse (PPARαΔKPT) showed decreased lipid and glucose metabolism in the kidney during fasting. Metabolism in the other organs was increased, presumably as a means of compensating for the impaired kidney metabolism.
Daiki Aomura, Takayuki Nimura, Kosuke Yamaka, Yosuke Yamada, Makoto Harada, Takero Nakajima, Takefumi Kimura, Koji Hashimoto, Hiroyuki Kanno, Motoko Yanagita, Frank J. Gonzalez, Naoki Tanaka, Yuji Kamijo   +12 more
wiley   +1 more source

Genetic Regulation and Breeding Application of Medium-Chain Fatty Acids Metabolism in Rice. [PDF]

Biology (Basel)
Zubair M, Tong X, Ashraf A, Li H, Li G, Xin A, Chen J, Wang Y, Li Z, Huang J, Cheng Y, Zhang J, Ying J.   +12 more
europepmc   +1 more source

Inactivation of the Burkholderia Toxin Malleicyprol by Enzymatic Cyclopropanol Ring Opening

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Burkholderia pseudomallei and Burkholderia mallei are dangerous pathogens that cause severe diseases with high mortality rates. Their virulence relies in part on malleicyprols, potent toxins containing a highly reactive cyclopropanol group. In this study, we identify BurK, a heme‐dependent oxidoreductase that neutralizes malleicyprols by enzymatically ...
Jonas Fiedler, Ingrid Richter, Katharina Dornblut, Alicia Scharf, Christian Hertweck   +4 more
wiley   +1 more source

BAHD acyltransferase from dragon fruit enables production of phyllocactin in engineered yeast. [PDF]

FEMS Yeast Res
Glitz C, Dyekjær JD, Mattitsch S, Babaei M, Borodina I.   +4 more
europepmc   +1 more source

Innate Immune Regulation: ABHD17 Is Calling NOD2 Back From Duty. [PDF]

Cell Mol Gastroenterol Hepatol
Kufer TA.
europepmc   +1 more source

Lipid droplets in the tumor microenvironment: Biogenesis, functional diversity, and therapeutic targeting. [PDF]

Chin Med J (Engl)
Zhong J, Liu Y, Wang C, Li S, Bian XW, Ping YF.   +5 more
europepmc   +1 more source