Results 91 to 100 of about 171,066 (327)
Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals. [PDF]
, 2016 IFIT (interferon-induced with tetratricopeptide repeats) proteins are critical mediators of mammalian innate antiviral immunity. Mouse IFIT1 selectively inhibits viruses that lack 2'O-methylation of their mRNA 5' caps.
Daugherty, Matthew D +3 more
core +1 more source
Microbiome Single Cell Atlases Generated with a Commercial Instrument
Advanced Science, EarlyView.Single cell sequencing is valuable for dissecting complex systems and uncovering unique features in individual cell types. However, tools for single cell microbial analysis are limited. Easily Accessible Single microbe sequencing (EASi‐seq), which adapts a commercially available single cell platform for efficient sequencing of single microbial genomes ...
Xiangpeng Li +8 more
wiley +1 more source
Therapeutic potential of ADAM10 modulation in Alzheimer’s disease: a review of the current evidence
Cell Communication and Signaling, 2023 Alzheimer’s disease (AD), the most common neurodegenerative disease worldwide, is caused by loss of neurons and synapses in central nervous system.
Mohammad Rafi Khezri +2 more
doaj +1 more source
Advanced Science, EarlyView.This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie +8 more
wiley +1 more source
Deciphering Cell Type Abundance in Proteomics Data Through Graph Neural Networks
Advanced Science, EarlyView.GraphDEC constructs pseudo bulk reference data using a mixup strategy, then learns low dimensional representations via autoencoders to model intra and inter dataset relationships. These are processed through a multi view adaptive neighborhood aware GNN, integrating reference, target, and joint graphs.
Zhiming Dai +7 more
wiley +1 more source
Transmembrane collagen XVII, an epithelial adhesion protein, is shed from the cell surface by ADAMs [PDF]
The EMBO Journal, 2002 Collagen XVII, a type II transmembrane protein and epithelial adhesion molecule, can be proteolytically shed from the cell surface to generate a soluble collagen. Here we investigated the release of the ectodomain and identified the enzymes involved.
Tryggvason, K +10 more
openaire +4 more sources
Molecular studies on a complex of potyviruses infecting solanaceous crops, and some specific virus-host interactions [PDF]
, 2003 This thesis constitutes a comprehensive analysis of the molecular and biological characteristics of three potyviruses (genus Potyvirus, family Potyviridae) naturally occurring in cultivated and wild species of family Solanaceae: Peru tomato virus (PTV ...
Spetz, Carl
core
PubServer: literature searches by homology. [PDF]
, 2014 PubServer, available at http://pubserver.burnham.org/, is a tool to automatically collect, filter and analyze publications associated with groups of homologous proteins.
Godzik, Adam +3 more
core +4 more sources
Advanced Science, EarlyView.This study deciphers maternal‐driven microbial transmission in pigs using a deep learning model (maternal–offspring microbial transmission model), identifying Christensenellaceae R‐7 group as a key transmitted taxon. Filtered galacto‐oligosaccharides‐targeted Christensenellaceae R‐7 group alters offspring microbial functions via maternal ...
Haibo Shen +9 more
wiley +1 more source
Advanced Science, EarlyView.This study proposes a pioneering method leveraging transfer learning to optimize multiple indicators in meta‐biosensor design, achieving the multiple‐indicator comprehensive optimization. By adopting frequency shift as a unified criterion, this study quantifies the contribution ratio of each performance indicator to the biosensor, which facilitates ...
Shengfeng Wang +6 more
wiley +1 more source