Results 111 to 120 of about 171,066 (327)

The Prediction of Intrinsically Disordered Proteins Based on Feature Selection

Algorithms, 2019
Intrinsically disordered proteins perform a variety of important biological functions, which makes their accurate prediction useful for a wide range of applications.
Hao He, Jiaxiang Zhao, Guiling Sun
doaj   +1 more source

Commentary: The missing sabertooth baculum—At what point might the absence of evidence reasonably be considered evidence of absence?

The Anatomical Record, EarlyView.
Abstract Most carnivorans and all modern felids have ossified bacula; however, no machairodont baculum has ever been identified. This is true despite the many fairly complete skeletons found around the world of several sabertooth taxa. Although the bacula of modern felids are much smaller than those of canoids (even the least weasel's baculum is longer
Adam Hartstone‐Rose
wiley   +1 more source

Decoding regulatory programs underlying placode and dermal condensate cell fate commitment during hair follicle induction via single‐cell multi‐omics analysis

Animal Research and One Health, EarlyView.
The experimental framework of the study encompasses sample collection, single‐cell data analysis, and experimental validation. Abstract Understanding differences in chromatin state and changes in gene regulatory landscape of placode (Pc) and dermal condensate are crucial for decoding hair follicle (HF) morphogenesis programs.
Fang Li, Minghao Li, Tongtong Zhang, Menghua Sui, Hasan Khatib, Xin Wang   +5 more
wiley   +1 more source

Variability in intestinal drug metabolizing enzymes and transporters in Crohn's disease and potential impact on oral drug absorption

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of study was to generate quantitative data on the abundance of drug‐metabolizing enzymes and transporters (DMETs) in inflamed and non‐inflamed Crohn's disease (CD) ileum and colon, for incorporation into physiologically based pharmacokinetic (PBPK) models, enabling prediction of oral drugs' pharmacokinetics (PK) perturbation in CD patients.
Sarah Alrubia, Brahim Achour, Zubida M. Al‐Majdoub, Amin Rostami‐Hodjegan, Jill Barber   +4 more
wiley   +1 more source

PersLay: A Neural Network Layer for Persistence Diagrams and New Graph Topological Signatures

, 2020
Persistence diagrams, the most common descriptors of Topological Data Analysis, encode topological properties of data and have already proved pivotal in many different applications of data science.
Carrière, Mathieu, Chazal, Frédéric, Ike, Yuichi, Lacombe, Théo, Royer, Martin, Umeda, Yuhei   +5 more
core  

The feasibility of pharmacokinetic‐based dosing of hydroxyurea for children with sickle cell anaemia in Uganda: Baseline results of the alternative dosing and prevention of transfusions trial

British Journal of Clinical Pharmacology, EarlyView.
Abstract Pharmacokinetic (PK)‐guided dosing of hydroxyurea for children with sickle cell anaemia (SCA) could optimize dosing and improve outcomes, but its feasibility has not been demonstrated in low‐resource settings where the majority of affected children live.
Alexandra Power‐Hays, Ruth Namazzi, Min Dong, Caroline Kazinga, Charles Kato, Sadat Aliwuya, Kathryn McElhinney, Andrea L. Conroy, Adam Lane, Chandy John, Alexander A. Vinks, Teresa Latham, Robert O. Opoka, Russell E. Ware   +13 more
wiley   +1 more source

Novosadski golozrni, a spring oat variety [PDF]

Selekcija i Semenarstvo, 2001
The naked oat variety Novosadski golozrni was developed from a cross between the variety Adam and a spring-type naked oat line from Canada. The variety is early, medium tall, with excellent resistance to lodging. The yield of Novosadski golozrni is 30-40%
Pržulj Novo, Mihailović Vojislav, Momčilović Vojislava   +2 more
doaj  

Hybrid Modeling of the Reversed‐Phase Chromatographic Purification of an Oligonucleotide: Few‐Shot Learning From Differentiable Physics Solver‐in‐the‐Loop

Biotechnology and Bioengineering, EarlyView.
The DP‐SOL hybrid modeling framework was employed to model the reversed‐phase chromatographic purification of oligonucleotides. By combining differentiable physics and neural networks at the solver level, DP‐SOL outperforms traditional mechanistic models in prediction accuracy, captures complex process dynamics and offers a robust approach for ...
Yu‐Cheng Chen, Ismaele Fioretti, Dong‐Qiang Lin, Mattia Sponchioni   +3 more
wiley   +1 more source

LRP1 shedding in human brain: roles of ADAM10 and ADAM17

Molecular Neurodegeneration, 2009
Background The low-density lipoprotein receptor-related protein 1 (LRP1) plays critical roles in lipid metabolism, cell survival, and the clearance of amyloid-β (Aβ) peptide. Functional soluble LRP1 (sLRP1) has been detected in circulating human placenta;
Reiss Karina, Verbeek Marcel M, Tran Hien, Zhang Juan, Liu Qiang, Estus Steven, Bu Guojun   +6 more
doaj   +1 more source

Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin α6β1: Implications for murine fertilization [PDF]

, 1999
Michellee S. Chen, Kenneth S. K. Tung, Scott A. Coonrod, Yûji Takahashi, Dora Bigler, Alice C. Chang, Yoshio Yamashita, Paul W. Kincade, John C. Herr, Judith M. White   +9 more
openalex   +1 more source