Results 121 to 130 of about 171,066 (327)

Immunosuppressive JAG2+ tumor‐associated neutrophils hamper PD‐1 blockade response in ovarian cancer by mediating the differentiation of effector regulatory T cells

Cancer Communications, EarlyView.
Abstract Background Tumor‐associated neutrophils (TANs) play a critical role in modulating immune responses and exhibit significant heterogeneity. Our previous study demonstrated that jagged canonical Notch ligand 2 (JAG2)+ TANs were associated with an immunosuppressive microenvironment in high‐grade serous ovarian cancer (HGSOC), but the underlying ...
Chenyang Wang, Moran Yang, Yujing Zhong, Kankan Cao, Xueling Wang, Chen Zhang, Yiying Wang, Mengdi He, Jiaqi Lu, Guodong Zhang, Yan Huang, Haiou Liu   +11 more
wiley   +1 more source

Therapeutic Challenge with a CDK 4/6 Inhibitor Induces an RB-Dependent SMAC-Mediated Apoptotic Response in Non-Small Cell Lung Cancer. [PDF]

, 2018
Purpose: The retinoblastoma tumor suppressor (RB), a key regulator of cell-cycle progression and proliferation, is functionally suppressed in up to 50% of non-small cell lung cancer (NSCLC).
Addya, Sankar, Bhardwaj, Anshul, Birbe, Ruth, Chellappagounder, Thangavel, Den, Robert B., Dicker, Adam P., Ertel, Adam, Ettickan, Boopathi, Haber, Alex, Knudsen, Karen E., Liu, Yi, McNair, Christopher, Perepelyuk, Maryna, Salvino, Joseph M., Shoyele, Sunday   +14 more
core   +1 more source

Activation of human NK cells by Plasmodium-infected red blood cells.

, 2012
This chapter describes a protocol to assess activation of human NK cells following in vitro stimulation with malaria-infected red blood cells. Activation is assessed by flow cytometry, staining for cell surface expression of CD69 and accumulation of ...
Horowitz, Amir, Riley, Eleanor M
core   +1 more source

PCSK‐9 Inhibitors Can Significantly Improve the Coronary Slow Flow Caused by Elevated Lipoprotein (a) in ST‐Elevation Myocardial Infarction Patients With Chronic Kidney Disease

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Coronary slow flow and no reflow significantly predict poor prognosis in acute myocardial infarction (AMI) patients, especially those with chronic kidney disease (CKD). Early identification of factors contributing to these conditions can mitigate ischemic events and improve outcomes.
Hao Xu, Ziqing Wang, Dan Chen, Haojie Zhang, Junhua Ge, Jian Li   +5 more
wiley   +1 more source

Prevalence of Cystic Fibrosis Carrier Status in Chronic Rhinosinusitis Without Nasal Polyp

International Forum of Allergy &Rhinology, EarlyView.
Do‐Yeon Cho, Adam J. Skelton, Jessica W. Grayson, Justin H. Turner, Bradford A. Woodworth   +4 more
wiley   +1 more source

An Alternative Mechanistic Paradigm for the Electrochemical C‐Terminal Decarboxylation of Peptides

ChemElectroChem, EarlyView.
Chemoselectivity in electrochemical oxidations is largely influenced by oxidation potential which represents a challenge for selectively oxidizing higher potential functional groups in complex substrates. Herein, a molecular binding strategy that selectively oxidizes the C‐terminal acid of a model peptide containing an electron‐rich tyrosine residue by
Adam J. Sowers, Kevin D. Moeller, Kim S. Halskov   +2 more
wiley   +1 more source

Inhibition of the clathrin terminal domain – amphiphysin protein‐protein interaction. Probing the Pitstop® 2 aromatic moiety.

ChemMedChem, Accepted Article.
Pitstop 2, (Z)‐N‐(5‐(4‐bromenzylidene)‐4‐oxo‐4,5‐dihydrothiazol‐2‐yl)naphthalene‐1‐sulfonamide (1), inhibits the clathrin terminal domain‐ amphiphysin interaction (NTD‐PPI) and has been widely used to investigate endocytosis. In this work we report on the synthesis of 56 novel Pitstop 2 analogues via four discrete focused libraries.
Kate Prichard, Mark J Robertson, Ngoc Chau, Jing Xue, Martin Neuenschwander, Uwe Fink, Andre Horatscheck, Marc Nazare, Phillip J Robinson, Volker Haucke, Adam McCluskey   +10 more
wiley   +1 more source

Jagged1 protein processing in the developing mammalian lens

Biology Open, 2019
Notch signaling regulates a multitude of cellular processes. During ocular lens development this pathway is required for lens progenitor growth, differentiation and maintenance of the transition zone.
Mina Azimi, Nadean L. Brown
doaj   +1 more source

ADAM 12, a Disintegrin Metalloprotease, Interacts with Insulin-like Growth Factor-binding Protein-3 [PDF]

, 2000
Zengdun Shi, Wenzhong Xu, Frosty Loechel, Ulla M. Wewer, Liam J. Murphy   +4 more
openalex   +1 more source

Unfolding of the Villin Headpiece Domain: Revealing Structural Heterogeneity with Time‐Resolved X‐Ray Solution Scattering and Markov State Modeling

ChemPhysChem, EarlyView.
The unfolding of villin headpiece 35 (HP35) and a double‐norleucine variant (2F4K) using a temperature‐jump and time‐resolved X‐ray solution scattering is examined. HP35 displays a two‐state kinetic model, while 2F4K indicates a transient intermediate.
Adam K. Nijhawan, Arnold M. Chan, Madeline B. Ho, Changmin Lee, Irina Kosheleva, Lin X. Chen, Kevin L. Kohlstedt   +6 more
wiley   +1 more source