Results 81 to 90 of about 4,617,323 (138)

ADAMTS-13 assays in thrombotic thrombocytopenic purpura

, 2010
ADAMTS-13, the thirteenth member of the ADAMTS (A Disintegrin And Metalloprotease with Thrombo-Spondin 1 repeats) family, is the plasma metalloprotease responsible for regulating the multimeric structure of VWF. In congenital or acquired deficiency it is
R. Palla, M. A. Scully, I. Mackie, S. J. Machin, F. Peyvandi, L.A. Lotta   +5 more
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ADAMTS-13: diagnóstico de laboratorio

, 2020
ADAMTS-13 es una desintegrina y metaloproteasa, zinc y calcio dependiente, codificada en el cromosoma humano 9q34. Su rol primario es clivar los multímeros ultra grandes del factor de Von Willebrand (ULVWF) originando sus diferentes formas moleculares ...
Aranda Aranda, Federico Manuel, Larrañaga, Gabriela de, Lencinas, Gisela, Peres, Silvia   +3 more
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ADAMTS -1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes [PDF]

, 2006
ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) enzymes are a recently described group of metalloproteinases. The substrates degraded by ADAMTS-1, -4 and -5 suggests that they play a role in turnover of extracellular matrix in the
Woodroofe, N., Surr, J., Allan, S., Stock, C. J., Cross, A. K., Haddock, G., Buttle, D. J., Bunning, R. A.   +7 more
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ADAMTS-1 is present on nuclei of invasive ductal carcinoma cells but not on luminal cells of normal breast tissue.

, 2016
(A) Immunohistochemistry shows ADAMTS-1 inside the nucleus of cancer cells (arrows pointed to dot-like structures). Cells under division or stromal-like cells do not present ADAMTS-1 (arrowheads).
Ruy G. Jaeger (618268), Suély V. Silva (3233223), Maíra A. Lima (3233220), Vanessa M Freitas (3233226), Nathalie Cella (2889740)   +4 more
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ADAMTS-13, von Willebrand factor and related parameters in severe sepsis and septic shock

, 2007
BACKGROUND: Insufficient control of von Willebrand factor (VWF) multimer size as a result of severely deficient ADAMTS-13 activity results in thrombotic thrombocytopenic purpura associated with microvascluar thrombosis and platelet consumption, features ...
Zeerleder, S, Zeerleder, S., ten Cate, H, Wuillemin, W. A., Romani de Wit, T, Hack, C. E., van Mourik, J A, Kessler, P., Lämmle, B., Reitsma, P H, Kremer Hovinga, J A, Romani de Wit, T., Kremer Hovinga, J. A., van Mourik, J. A., Wuillemin, W A, Lämmle, B, Kessler, P, ten Cate, H., Reitsma, P. H., Hack, C E   +19 more
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Predictive value of ADAMTS-13 on concealed chronic renal failure in COPD patients

, 2017
Mian Zeng, Qingui Chen, Wenjie Liang, Wanmei He, Haichong Zheng, Chunrong Huang Department of Medical Intensive Care Unit, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China Background: Impaired renal function is often neglected ...
Chen QG, Zheng HC, Huang CR, Zeng M, He WM, Liang WJ   +5 more
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Multi-step binding of ADAMTS-13 to von Willebrand factor

, 2009
Background: ADAMTS-13 proteolytic activity is controlled by the conformation of its substrate, von Willebrand factor (VWF), and changes in the secondary structure of VWF are essential for efficient cleavage.
Anderson, PJ, Feys, Hendrik, Vanhoorelbeke, K, Sadler, JE, Majerus, EM   +4 more
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ADAMTS-1 and Aggrecan are both in the nucleus.

, 2016
(A) Colocalization of ADAMTS-1 and aggrecan. ADAMTS-1 (red), Aggrecan (green) and Nuclei (blue). Aggrecan is found in nuclei and cytoplasm and is colocalized with ADAMTS-1 in cell nucleolus (white arrows) in MCF7 and MDA-MB-231. Scale bar: 5 μm.
Ruy G. Jaeger (618268), Suély V. Silva (3233223), Maíra A. Lima (3233220), Vanessa M Freitas (3233226), Nathalie Cella (2889740)   +4 more
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Acquired ADAMTS-13 Deficiency in Pediatric Patients with Severe Sepsis

, 2012
[[abstract]]We studied the state of ultralarge von Willebrand factor (ULVWF) proteolysis in 21 pediatric patients with severe sepsis and found that the overall group of patients had moderately reduced ADAMTS-13 activity, but 31% had severe enzymatic ...
Nguyen, Trung C. ; Liu, Anne; Liu, Li; Ball, Chalmette; Choi, Hiuwan; May, William S. ; Aboulfatova, Khatira; Bergeron, Angela L. ; Dong, Jing-fei
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Differential expression of ADAMTS -1, -4, -5 and TIMP -3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis [PDF]

, 2005
Experimental autoimmune encephalomyelitis (EAE) is an animal model of inflammatory demyelination, a pathological event common to multiple sclerosis (MS). During CNS inflammation there are alterations in the extracellular matrix (ECM).
Woodroofe, N., Bunning, R. A D, Woodroofe, M. N., Plumb, J., Surr, J., Cross, A. K., Haddock, G., Buttle, D. J.   +7 more
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