Results 61 to 70 of about 377 (71)

血浆ADAMTS-13活性和NLR在急性肺血栓栓塞症中的诊断价值

Zhongshan Daxue xuebao. Yixue kexue ban, 2021
目的探究急性肺血栓栓塞症（PTE）患者血浆血管性血友病因子（vWF）活性、血管性血友病因子裂解酶（ADAMTS-13）活性、中性粒细胞计数与淋巴细胞计数比率（NLR）健康对照组的表达差异，探究ADAMTS-13活性、NLR对于PTE患者的诊断意义。方法共纳入急性PTE患者64例及健康对照者30例，收集相关临床数据并采用酶联免疫吸附试验（ELISA）检测血浆ADAMTS-13活性、vWF活性，分析比较ADAMTS-13活性、vWF活性的组间差异及其与其他临床指标的相关性，绘制受试者工作特征曲线（ROC ...
胡子旋, 何婉媚, 曾勉
doaj  

Severe ADAMTS-13 deficiency without hemolysis as a cause of cryptogenic stroke: A single center case series

Journal of Stroke and Cerebrovascular Diseases
Introduction: Cerebral Infarction due to Severe ADAMTS-13 Deficiency (CISAD) remains an underrecognized cause of cryptogenic stroke. Despite the absence of classic hematologic features, CISAD confers a risk of recurrent ischemic events if not promptly ...
Johanna Seiden, MD, MPH, Juan Felipe Daza-Ovalle, MD, Zhengrui Xiao, MD, Olga Rubalsky, MD, Irina Murakhovskaya, MD, Ellen Friedman, MD, Kathryn Kirchoff-Torres, MD, Daniel Labovitz, MD, MS, Charles Esenwa, MD, MS   +8 more
doaj   +1 more source

Role of a Tissue Factor Pathway Inhibitor, the Plasma Proteinase ADAMTS-13 and its Inhibitor in the Pathogenesis of Acute Respiratory Distress Syndrome in A/H1N1 Influenza

Общая реаниматология, 2011
Objective: to study the role of a tissue factor pathway inhibitor (TFPI), the metalloproteinase ADAMTS-13, and its inhibitor in the pathogenesis of acute respiratory distress syndrome (ARDS) in A/H1N1 influenza. Subjects and methods.
E. V. Prutkina, A. V Malyarchikov, N. N. Tsybikov, K. G. Shapovalov, N. V. Isakova   +4 more
doaj   +1 more source

Decreased plasma ADAMTS-13 activity as a predictor of postoperative bleeding in cyanotic congenital heart disease

Clinics, 2013
OBJECTIVE: To analyze the preoperative plasma antigenic concentration and activity of von Willebrand factor and its main cleaving protease ADAMTS-13 in pediatric patients with cyanotic congenital heart disease undergoing surgical treatment and ...
Rosangela P.S. Soares, Sérgio P. Bydlowski, Marcelo B. Jatene, Janete Ferreira Hironaka, Antonio Augusto Lopes   +4 more
doaj  

Investigation of ADAMTS-13 levels in patients with COVID-19 infection

Journal of Infection in Developing Countries
Introduction: Coronavirus disease 2019 (COVID-19) patients are predisposed to thrombotic events. COVID-19 coagulopathy can be associated with ADAMTS-13 (a disintegrin-like and metalloprotease with thrombospondin type I repeats 13) levels. ADAMTS-13, the
Hüseyin H Kutlu, Arzu Sahin, Soycan Mizrak, Abdurrahman Yilmaz, Songul Doganay, Serdar Gungor, Sema Yilmaz   +6 more
doaj   +1 more source

Daratumumab for relapsed refractory immune thrombotic thrombocytopenic purpura: initial response and long-term follow-up

Research and Practice in Thrombosis and Haemostasis
Background: Management of patients with refractory or frequently relapsing (r/r) immune thrombotic thrombocytopenic purpura (iTTP) remains challenging, with no established consensus on optimal therapeutic strategies.
Roman Schimmer, Jana van den Berg, Marissa Schraner, Alice Trinchero, Andreas Holbro, Johanna A. Kremer Hovinga, Jan-Dirk Studt   +6 more
doaj   +1 more source

Prophylactic use of recombinant ADAMTS-13 during pregnancy for congenital thrombotic thrombocytopenic purpura

Research and Practice in Thrombosis and Haemostasis
Background: Congenital thrombotic thrombocytopenic purpura (cTTP) related to ADAMTS-13 deficiency is associated with a maternal risk of death of 10% and a risk of fetal loss greater than 50% without treatment.
Éloïse Colliou, Agnès Ribes, Clotilde Gaible, Mathilde Marlas, David Ribes, Isabelle Labadens, Paul Guerby, Stanislas Faguer   +7 more
doaj   +1 more source

A CASE OF THROMBOTIC THROMBOCYTOPENIC PURPURA RELATED TO MALIGNITY AND CHEMOTHERAPY

Hematology, Transfusion and Cell Therapy
Objective: Thrombotic thrombocytopenic purpura (TTP) is a life-threatening multisystem disease. TTP progresses with Microangiopathic hemolytic anemia (MAHA), fever, thrombocytopenia, neurological symptoms, and renal failure.
Ebru Kavak Yavuz, Songül Beskisiz Dönen, Etem Özkaya, Esra Pirinççi, Abdullah Karakuş, Orhan Ayyıldız   +5 more
doaj   +1 more source

Serum biomarkers reflecting progression of knee osteoarthritis: a stage-based evaluation of TGF-β3, ADAMTS-4, ADAMTS-5, and MMP-13

BMC Musculoskeletal Disorders
Background Knee osteoarthritis (KOA) is a progressive degenerative joint disease characterized by extracellular matrix (ECM) degradation and dysregulated inflammatory signaling.
Omer Esmez, Zubeyde Ercan, Secil Yılmaz, Meryem Sedef Doğru   +3 more
doaj   +1 more source

PO20 | DYSFUNCTION OF THE ADAMTS-13 / VON WILLEBRAND FACTOR AXIS, MEDIATED BY NETOSIS, AS A DRIVER OF PROTHROMBOTIC STATE AND UNFAVORABLE PROGNOSIS IN ONCOGYNECOLOGICAL PATIENTS

Bleeding, Thrombosis and Vascular Biology
Introduction. An imbalance between von Willebrand factor (VWF) and its primary protease, ADAMTS-13, plays a crucial role in the pathogenesis of microthrombosis and endotheliopathy.
Alexander Makatsariya
doaj