Results 61 to 70 of about 4,617,323 (138)

ADAMTS-13: laboratory diagnosis [PDF]

, 2020
ADAMTS-13 es una desintegrina y metaloproteasa, zinc y calcio dependiente, codificada en el cromosoma humano 9q34. Su rol primario es clivar los multímeros ultra grandes del factor de Von Willebrand (ULVWF) originando sus diferentes formas moleculares ...
Lencina, Gisele, Perés Wingeyer, Silvia, de Larrañaga, Gabriela Fernanda   +2 more
core   +1 more source

Mechanistic insight into multiple antibody binding to ADAMTS13 in immune thrombotic thrombocytopenic purpura

Research and Practice in Thrombosis and Haemostasis
Background: Antibody-mediated inhibition of von Willebrand factor (VWF) cleavage by ADAMTS-13 results in immune thrombotic thrombocytopenic purpura (iTTP).
Konstantine Halkidis, Chan Meng, Vikram G. Pillai, Madison Shay, Szumam Liu, X. Long Zheng   +5 more
doaj   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Brain metastasis‐associated fibroblasts shape the tumour microenvironment to enhance cancer cell invasion

Brain Pathology, EarlyView.
Brain metastasis‐associated fibroblasts are active stromal components of the metastatic niche characterised by extracellular matrix remodelling and production of pro‐migratory mediators. They promote monocyte and cancer cell migration and enhance cancer cell invasion while having no growth‐promoting effect on cancer cells.
Barbora Výmolová, Lucie Pfeiferová, Tadeáš Karel Smetana, Petr Výmola, Nikola Ternerová, Michal Zubaľ, Michal Kolář, Jana Šáchová, Soňa Gyönyörová, Eva Balážiová, Magdalena Houdová Megová, Jakub Červenka, Helena Kupcová Skalníková, Michal Španko, Karel Smetana Jr., Lukáš Lacina, David Netuka, Robert Tomáš, Petr Bušek, Aleksi Šedo   +19 more
wiley   +1 more source

MAB 1810 (Millipore) also recognizes ADAMTS-1 in nuclei.

, 2016
(A) Immunofluorescence was performed in MCF-10A cells with another commercially available antibody against ADAMTS-1, and the same labeling pattern is observed.
Ruy G. Jaeger (618268), Suély V. Silva (3233223), Maíra A. Lima (3233220), Vanessa M Freitas (3233226), Nathalie Cella (2889740)   +4 more
core   +1 more source

Clinical observation of a patient with thrombotic thrombocytopenic purpura with renal and intestinal lesions

Терапевтический архив, 2019
The article presents a brief description of a rare disease - thrombotic thrombocytopenic purpura (Moshkovits - disease), which is based on the deficiency of ADAMTS-13 metalloproteinase, leading to the development of thrombotic microangiopathy with the ...
A G Stolyar, P V Avdonin, I E Valamina, E S Stolyarevich   +3 more
doaj   +1 more source

Ammonia Accumulation Drives Intervertebral Disc Degeneration by Triggering Ammonia‐Induced Cell Death Through Lysosome–Mitochondria Crosstalk

Cell Proliferation, EarlyView.
Mechanical strain disrupts the lysosome‐mitochondria axis via GLS1‐mediated ammonia toxicity, causing NP cell death and ECM breakdown in IVDD. CB839‐mediated GLS1 inhibition effectively rescues cellular homeostasis and alleviates disc degeneration.
Yang Zhang, Yucheng Gao, Shuhang Dong, Shuanggong Liu, Lei Liu, Ziyi Song, Jie Xu, Yijun Rong, Guangxu Song, Yingze Zhang, Dongjin Wu, Zengxin Gao   +11 more
wiley   +1 more source

ADAMTS-1 protein is predominantly in the cell nucleus.

, 2016
Western blot containing cytoplasmic and nuclear fractions from MCF-10A, MCF-7, and MDA-MB-231 cells, probed for ADAMTS-1, β-actin, histone and GAPDH.
Ruy G. Jaeger (618268), Suély V. Silva (3233223), Maíra A. Lima (3233220), Vanessa M Freitas (3233226), Nathalie Cella (2889740)   +4 more
core   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Recombinant ADAMTS-13: first-in-human pharmacokinetics and safety in congenital thrombotic thrombocytopenic purpura [PDF]

, 2017
Key PointsFirst-in-human, phase 1 study, recombinant ADAMTS-13 was safe, nonimmunogenic, and tolerated in congenital thrombotic thrombocytopenic purpura.
Hibbard, Christopher, Johanna A. Kremer Hovinga, Scully, Marie, Fujimura, Yoshihiro, Michiko Kajiwara, Caterina Maggiore, Leah Martell, Martell, Leah, Karim Kentouche, Schneppenheim, Reinhard, Yoshihiro Fujimura, Kremer Hovinga, Johanna Anna, Rice, Lawrence, Doralt, Jennifer, Maggiore, Caterina, Ewenstein, Bruce, Knöbl, Paul, Marie Scully, Kajiwara, Michiko, Christopher Hibbard, Bruce Ewenstein, Jerzy Windyga, Paul Knöbl, Lawrence Rice, Reinhard Schneppenheim, Kentouche, Karim, Jennifer Doralt, Windyga, Jerzy   +27 more
core   +3 more sources