Results 41 to 50 of about 4,617,323 (138)

ADAMTS-4 and ADAMTS-5 are found in the cytoplasm.

, 2016
Western blot containing cytoplasmic and nuclear fractions from MCF-10A (A), MCF-7 (B) and MDA-MB-231 (C) cells, probed for ADAMTS-4, ADAMTS-5, β-actin, histone and GAPDH.
Ruy G. Jaeger (618268), Suély V. Silva (3233223), Maíra A. Lima (3233220), Vanessa M Freitas (3233226), Nathalie Cella (2889740)   +4 more
core   +1 more source

Primary cilia disassembly down regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes [PDF]

, 2014
SummaryObjectiveHedgehog signalling is mediated by the primary cilium and promotes cartilage degeneration in osteoarthritis. Primary cilia are influenced by pathological stimuli and cilia length and prevalence are increased in osteoarthritic cartilage ...
Knight, M.M., Chapple, JP, Chapple, J.P., Knight, MM, Thompson, CL, Thompson, C.L.   +5 more
core   +1 more source

ADAMTS-13 deficiency: can it cause chronic renal failure?

, 2010
We describe a case of a 45-year-old woman with progressive chronic kidney disease (CKD), macrocytic anaemia without fragments or thrombocytopaenia, and thrombotic microangiopathy on renal biopsy.
Bramham, Kate, Horsfield, Catherine, Camilleri, R., V. McDonald, C. Horsfield, B. J. Hunt, Hilton, Rachel, R. Hilton, Hunt, B.J., McDonald, Vickie, Hunt, Beverley, Hilton, R., Bramham, K., McDonald, V., K. Bramham, Camilleri, Raymond, Horsfield, C., R. Camilleri   +17 more
core   +1 more source

Further characterization of ADAMTS-13 inactivation by thrombin [PDF]

, 2007
Background: The multimeric size and platelet-tethering function of von Willebrand factor (VWF) are modulated by the plasma metalloprotease, a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS-13).
Lane, DA, Chion, CKNK, Zanardelli, S, Lam, JK, Crawley, JTB   +4 more
core   +1 more source

Clinical significance of assessing ADAMTS-13 and von Willebrand factor level in COVID-19 convalescent pregnant women

Акушерство, гинекология и репродукция, 2023
Introduction. Coronavirus infection is associated with severe endotheliopathy, thromboinflammation and immunothrombosis leading to excessive release of von Willebrand factor (vWF) multimers from Weibel–Palade bodies, which can affect activity of ADAMTS ...
N. R. Gashimova, K. N. Grigoreva, V. O. Bitsadze, L. L. Pankratyeva, J. Kh. Khizroeva, M. V. Tretyakova, Ya. M. Shammut, E. Iu. Iupatov, V. I. Tsibizova, J.-K. Gris, D. V. Blinov, A. D. Makatsariya   +11 more
doaj   +1 more source

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source

ADAMTS-13 glycans and conformation-dependent activity. [PDF]

, 2017
Background: ADAMTS-13 activity can be regulated by its conformation, whereby interactions between the C-terminal CUB domains and the spacer domain maintain ADAMTS-13 in a closed conformation.
Laffan, M.A., McKinnon, T.AJ., O'Brien, HER, M.A. Laffan, Henne, P., Doerr, A, K. Vanhoorelbeke, A.A. Nowak, Henne, P, Doerr, A., Nowak, AA, T.A.J. McKinnon, Nowak, A.A., O'Brien, H.ER., Vanhoorelbeke, K, Vanhoorelbeke, Karen, H.E.R. O'Brien, P. Henne, Laffan, MA, McKinnon, TAJ, A. Doerr   +20 more
core   +1 more source

The role of ADAMTS‐13 and von Willebrand factor in cancer patients: Results from the Vienna Cancer and Thrombosis Study

Research and Practice in Thrombosis and Haemostasis, 2019
Essentials Cancer is associated with increased risk of developing venous thrombosis. Cancer patients were studied for ADAMTS‐13 and VWF levels and occurrence of venous thrombosis.
Hanna L. Obermeier, Julia Riedl, Cihan Ay, Silvia Koder, Peter Quehenberger, Rupert Bartsch, Alexandra Kaider, Christoph C. Zielinski, Ingrid Pabinger   +8 more
doaj   +1 more source

Assessment of ADAMTS-13 Level in Hospitalized Children with Serious Bacterial Infections as a Possible Prognostic Marker

Medicina, 2019
Background and objectives: In children, acute infection is the most common cause of visits in the primary care or emergency department. In 2002, criteria for diagnostics of pediatric sepsis were published, and then revised in 2016 as “life ...
Linda Rautiainen, Anna Cirko, Jana Pavare, Reinis Balmaks, Ilze Grope, Irina Katirlo, Gita Gersone, Peteris Tretjakovs, Dace Gardovska   +8 more
doaj   +1 more source

Deep Immunophenotyping Reveals Distinct Immune Signatures in Axial Spondyloarthritis and Psoriatic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are overlapping yet distinct conditions within the SpA spectrum. As divergent immunophenotypes may influence disease course and therapeutic response, we compared immune cell subsets, cytokine profiles, and inflammatory mediators.
Natalie Frede, Nils Craig‐Müller, Silke Kohrt, Marei‐Theresa Bott, Ulrich Salzer, Ana Cecilia Venhoff, Jens Thiel, Julia Frede, Reinhard E. Voll, Marta Rizzi, Raquel Lorenzetti, Nils Venhoff   +11 more
wiley   +1 more source