Results 21 to 30 of about 4,617,323 (138)

Relationship Between Intraluminal Thrombus Volume and Circulating ADAMTS-13 Activity in Abdominal Aortic Aneurysms [PDF]

EJVES Vascular Forum
Introduction: Abdominal aortic aneurysms (AAAs) with intraluminal thrombus (ILT) are suggested to be more prone to rupture than AAAs without. Prior studies indicate that the von Willebrand factor (vWf) plays a role in the formation of ILT since a ...
Qasam M. Ghulam, Jens P. Goetze, Nikolaj Eldrup, Jonas P. Eiberg   +3 more
doaj   +2 more sources

ADAMTS-13 activity in stroke of known and unknown cause: Relation to vascular risk factor burden [PDF]

Frontiers in Neurology, 2023
BackgroundThe identification of the underlying mechanism in ischemic stroke has important implications for secondary prevention. A disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13 (ADAMTS-13) has antithrombotic properties and
Gerrit M. Grosse, Andrei Leotescu, Jan-Thorben Sieweke, Sonja Schneppenheim, Ulrich Budde, Nora L. Ziegler, Saskia Biber, Maria M. Gabriel, Johanna Ernst, Ramona Schuppner, Ralf Lichtinghagen, Udo Bavendiek, Julian Widder, Julian Widder, Karin Weissenborn   +14 more
doaj   +2 more sources

Low ADAMTS‐13 predicts adverse outcomes in hospitalized patients with suspected heparin‐induced thrombocytopenia [PDF]

Research and Practice in Thrombosis and Haemostasis, 2021
Background Heparin‐induced thrombocytopenia (HIT) is a life‐threatening thrombotic complication after heparin exposure. However, the role of ADAMTS‐13 and von Willebrand factor (VWF) in the disease process and outcomes of HIT is not known.
Meng Chan, Xinyang Zhao, X. Long Zheng
doaj   +2 more sources

Therapeutic application of recombinant human ADAMTS-13 improves shock reversal and coagulation status in a trauma hemorrhage and transfusion rat model [PDF]

Intensive Care Medicine Experimental, 2020
Introduction In hemorrhaging trauma patients, the endothelium is activated, resulting in excessive endothelial synthesis of von Willebrand Factor (vWF), which may enhance micro-thrombi formation, resulting in obstruction of the microcirculation and ...
Mathijs R. Wirtz, Daan P. van den Brink, Joris J. T. H. Roelofs, J. Carel Goslings, Nicole P. Juffermans   +4 more
doaj   +2 more sources

Determination of vWF, ADAMTS-13 and Thrombospondin-1 in Venous Thromboembolism and Relating Them to the Presence of Factor V Leiden Mutation [PDF]

Clinical and Applied Thrombosis/Hemostasis
Thrombophilia in venous thromboembolism (VTE) is multifactorial. Von Willebrand factor (vWF) plays a major role in primary hemostasis. While elevated vWF levels are well documented in VTE, findings related to its cleaving protease (ADAMTS-13) are ...
Anwar Al-Awadhi PhD, Rajaa Marouf MBBch, DCP, FRCPath, Mehrez M. Jadaon MS, Mohammad M. Al-Awadhy MD   +3 more
doaj   +2 more sources

Prophylactic use of recombinant ADAMTS-13 during pregnancy for congenital thrombotic thrombocytopenic purpura [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: Congenital thrombotic thrombocytopenic purpura (cTTP) related to ADAMTS-13 deficiency is associated with a maternal risk of death of 10% and a risk of fetal loss greater than 50% without treatment.
Éloïse Colliou, Agnès Ribes, Clotilde Gaible, Mathilde Marlas, David Ribes, Isabelle Labadens, Paul Guerby, Stanislas Faguer   +7 more
doaj   +2 more sources

Sustained VWF-ADAMTS-13 axis imbalance and endotheliopathy in long COVID syndrome is related to immune dysfunction. [PDF]

J Thromb Haemost, 2022
Background: Prolonged recovery is common after acute SARS-CoV-2 infection; however, the pathophysiological mechanisms underpinning Long COVID syndrome remain unknown.
Fogarty H, Ward SE, Townsend L, Karampini E, Elliott S, Conlon N, Dunne J, Kiersey R, Naughton A, Gardiner M, Byrne M, Bergin C, O'Sullivan JM, Martin-Loeches I, Nadarajan P, Bannan C, Mallon PW, Curley GF, Preston RJS, Rehill AM, Baker RI, Cheallaigh CN, O'Donnell JS, Irish COVID-19 Vasculopathy Study (iCVS) Investigators.   +23 more
europepmc   +4 more sources

ADAMTS-13 and bleeding phenotype in von Willebrand disease. [PDF]

Res Pract Thromb Haemost, 2020
Background: The bleeding phenotype of von Willebrand disease (VWD) varies highly between patients and can only partly be explained by von Willebrand factor (VWF) parameters.
Boender J, Nederlof A, Meijer K, Mauser-Bunschoten EP, Cnossen MH, Fijnvandraat K, van der Bom JG, de Meris J, Laros-van Gorkom BAP, van Galen KPM, Eikenboom J, de Maat MPM, Leebeek FWG, WiN Study Group.   +13 more
europepmc   +12 more sources

Clinical significance of ADAMTS-13/vWF axis in pregnant women at different trimesters of gestation

Акушерство, гинекология и репродукция, 2023
Introduction. The pandemic of a novel coronavirus infection has demonstrated the importance of assessing the ADAMTS-13/vWF axis in patients with COVID-19, because a decline in this ratio mirrors disease severity.
K. N. Grigoreva, N. R. Gashimova, V. O. Bitsadze, L. L. Pankratyeva, J. Kh. Khizroeva, M. V. Tretyakova, V. I. Tsibizova, N. D. Degtyareva, A. V. Mulenkova, J.-C. Gris, M. V. Kvaratskheliia, E. Grandone, F. E. Yakubova, D. V. Blinov, A. D. Makatsariya   +14 more
doaj   +1 more source

Plasma Levels of ADAMTS-13 Antigen, ADAMTS-13 Inhibitor, ADAMTS-13 Activity, and Von Willebrand Factor in Patients with Behçet's Disease. [PDF]

Mediterr J Rheumatol
Background: Beh ; ccedil;et's Disease (BD) is characterised by recurrent aphthous oral and genital ulcers. Vascular involvement is one of the poor prognostic factors.
Karasu U, Erkek M, Ulutaş F, Demiray A, Çimen Y, Kaymaz S, Açıkbaş İ, Şenol H, Çobankara V.   +8 more
europepmc   +2 more sources