Results 31 to 40 of about 4,617,323 (138)

DEFICIENCY OF ADAMTS-13 IN SEPSIS PATIENTS AND ITS CORRELATION WITH MORBIDITY/ MORTALITY

Pakistan Armed Forces Medical Journal, 2021
Objective: To detect ADAMTS-13 deficiency in sepsis patients and its effect on in-hospital morbidity and mortality in adult patients of sepsis. Study Design: Cross sectional study.
Syed Owais Ali, Chaudhry Altaf Hussain, Dawood Ahmad, Rafia Mahmood, Syeda Sarwat Fatima, Taqdees Fatima   +5 more
doaj   +1 more source

ADAMTS-13 level in children with severe diarrhea-associated hemolytic uremic syndrome: Unmasking new association

Saudi Journal of Kidney Diseases and Transplantation, 2018
Severe deficiency of ADAMTS-13 leads to thrombotic thrombocytopenic purpura. Few studies have reported reduced activity of ADAMTS-13 in patients with atypical and typical hemolytic uremic syndrome (HUS).
Naglaa A Khalifa, Heba H Gawish, Noora A Khalifa, Doaa M Tawfeek, Saed M Morsy   +4 more
doaj   +1 more source

Immunothrombosis in cancer patients: contribution of neutrophil extracellular traps, ADAMTS-13 and von Willebrand factor

Акушерство, гинекология и репродукция, 2023
Introduction. Neutrophil extracellular traps (NETs) and von Willebrand factor (vWF) are integral players in thrombosis and inflammation in cancer patients. It has been increasingly evident that an active interplay exists between NETs and vWF.
E. V. Slukhanchuk, V. O. Bitsadze, A. G. Solopova, J. Kh. Khizroeva, V. I. Tsibizova, J.-K. Gris, I. Elalamy, D. V. Shcherbakov, L. L. Pankratyeva, L. A. Ashrafyan, A. D. Makatsariya   +10 more
doaj   +1 more source

ADAMTS proteases in cardiovascular physiology and disease [PDF]

Open Biology, 2020
The a disintegrin-like and metalloproteinase with thrombospondin motif (ADAMTS) family comprises 19 proteases that regulate the structure and function of extracellular proteins in the extracellular matrix and blood.
Salvatore Santamaria, Rens de Groot
doaj   +1 more source

Determination of anti-ADAMTS-13 autoantibody titers in ELISA: Influence of ADAMTS-13 presentation and autoantibody detection

, 2021
BACKGROUND: Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is caused by inhibitory and/or clearing anti-ADAMTS-13 (A Disintegrin and Metalloprotease with ThromboSpondin type 1 repeats, member 13) autoantibodies.
Mannik, Andres, Tellier, Edwige, Feys, Hendrik B., Kaplanski, Gilles, Vandenbulcke, Aline, Dekimpe, Charlotte, De Meyer, Simon F., Feys, Hendrik, Bonnez, Quintijn, Tersteeg, Claudia, Roose, Elien, Vanhoorelbeke, Karen, Kangro, Kadri, de Meyer, Simon   +13 more
core   +1 more source

Recombinant ADAMTS-13 Improves Survival of Mice Subjected to Endotoxemia [PDF]

, 2023
When stimulated by proinflammatory mediators, endothelial cells release ultra-large von Willebrand factor (ULVWF) multimers that are hyperactive in activating and aggregating platelets.
Huaizhu Wu, Trung Nguyen, Zhou, Zhou, Ma, Ruidong, Wu, Huaizhu, Liu, Li, Daniel Gao, Jingfei Dong, Zhou Zhou, Li Liu, Nguyen, Trung, Ruidong Ma, Gao, Daniel, Dong, Jingfei   +13 more
core   +1 more source

Plasmatic ADAMTS-13 metalloprotease and von Willebrand factor in children with cyanotic congenital heart disease

Brazilian Journal of Medical and Biological Research, 2013
Changes in plasma von Willebrand factor concentration (VWF:Ag) and ADAMTS-13 activity (the metalloprotease that cleaves VWF physiologically) have been reported in several cardiovascular disorders with prognostic implications.
R.P.S. Soares, S.P. Bydlowski, N.M. Nascimento, A.M. Thomaz, E.N.M. Bastos, A.A. Lopes   +5 more
doaj   +3 more sources

Thrombotic thrombocytopenic purpura as a rare cause of anemia with thrombocytopenia in childhood: report of 2 cases

The Turkish Journal of Pediatrics, 2019
Thrombotic thrombocytopenic purpura (TTP) is a rare multisystem disorder characterized by single or recurrent episodes of thrombocytopenia, microangiopathic hemolytic anemia and widespread microvascular thrombosis, which causes significant morbidity and
Oya Köker, Zeynep Yıldız Yıldırmak, Dildar Bahar Genç, Önder Kılıçaslan   +3 more
doaj   +1 more source

ADAMTS-13 proteolyzed by thrombin has reduced affinity for von Willebrand factor (VWF)

, 2011
(A) 6 n ADAMTS-13, 60 n thrombin-cleaved ADAMTS-13 (ADAMTS-13/FIIa) or 60 n thrombin-cleaved ADAMTS-13/6 n ADAMTS-13 (10:1 mix) was incubated with 10 n purified plasma-derived VWF in the presence of 1.5 urea and 5 m BaCl.
C K N K CHION (48919), S ZANARDELLI (48920), J T B CRAWLEY (48922), J K LAM (48918), D A LANE (48921)   +4 more
core   +1 more source

Prevalence of the ADAMTS-13 missense mutation R1060W in late onset adult thrombotic thrombocytopenic purpura

, 2008
Background: Thrombotic thrombocytopenic purpura (TTP) is most commonly associated with deficiency or inhibition of von Willebrand factor-cleaving protease (ADAMTS-13) activity.
Cohen, H., Machin, S.J., Crawley, J.T.B., Camilleri, R., Mackie, I.J., Skully, M., Lane, D.A., Starke, R.D.   +7 more
core   +1 more source