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Role of ADAMTS-1 in Atherosclerosis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2005 Objective— We investigated the potential role of ADAMTS-1 (a disintegrin and metalloprotease with thrombospondin motif type I) in atherogenesis. Methods and Results— ADAMTS-1 is expressed at the highest levels in the aorta when
Peter Brodin, Birgitta Rosengren
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Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively [PDF]
Oncogene, 2005 The exact role of a disintegrin and metalloproteinase with thrombospondin motifs-1 (ADAMTS-1) and the underlying mechanism of its involvement in tumor metastasis have not been established. We have now demonstrated that overexpression of ADAMTS-1 promotes pulmonary metastasis of TA3 mammary carcinoma and Lewis lung carcinoma cells and that a proteinase ...
Y-J, Liu, Y, Xu, Q, Yu
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Differential gene expression of ADAMTS-1, ADAMTS-9 and TIMP-3 in periodontitis
Biotechnic & Histochemistry, 2022A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) are metalloproteinases that bind to components of the extracellular matrix (ECM) to regulate tissue remodeling and homeostasis. ADAMTS can be inhibited by tissue inhibitors of metalloproteinases (TIMPs). Expression of ADAMTS increases under inflammatory conditions.
M. Ayşe Tayman, İsmail Koyuncu
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Adamts 1, 4, 5, 8, and 9 in Early Pregnancies
Fetal and Pediatric Pathology, 2017The aim of this study was to immunohistochemically investigate the presence and localization of ADAMTS 1, 4, 5, 8 and 9 in decidual and chorionic tissues in first trimester pregnancy losses.This study was conducted with early pregnancy failure decidual and chorionic tissue samples from 36 pregnant women in the first trimester of pregnancy (ongoing ...
Müberra, Namli Kalem +3 more
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THE PROTECTIVE ROLE OF ADAMTS-1 IN ALCOHOLIC LIVER FIBROSIS
Acta Medica Mediterranea, 2022<p style="text-align:justify;font-size:9px;font-family:Times;"><b><i>Introduction: </i></b><i>To explore the role of ADAMTS-1 in alcoholic liver fibrosis in mice, and to provide theoretical targets in clinical research and treatment of alcoholic liver fibrosis.<span> </span></i></p> ...
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Distribution patterns of the anti-angiogenic protein ADAMTS-1 during rat development
Acta Histochemica, 2005A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS-1) belongs to the large ADAM family of proteins. ADAMTS-1 contains a metalloproteinase domain, a disintegrin domain and three thrombospondin-like repeats but unlike ADAMs lacks a transmembrane domain.
Willy, Günther +4 more
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ADAMTS-1: A new human ovulatory gene and a cumulus marker for fertilization capacity
Molecular and Cellular Endocrinology, 2010ADAM-metallopeptidase with thrombospondin type 1 motifs-1 (ADAMTS-1) null female mice show impaired follicular development and ovulatory processes. However, ADAMTS-1 expression and function in human normal ovulation and folliculogenesis have not yet been determined.
Yuval, Yung +9 more
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Adamts-1 is essential for the development and function of the urogenital system.
Biology of reproduction, 2004Successful ovulation and implantation processes play a crucial role in female fertility. Adamts-1, a matrix metalloproteinase with disintegrin and thrombospondin motifs, has been suggested to be regulated by the progesterone receptor in the hormonal pathway leading to ovulation.
Mittaz, L. +7 more
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