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Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin [PDF]
Osteoarthritis and Cartilage, 2008 SummaryObjectiveAs we previously reported, ADAMTS-7 and ADAMTS-12, two members of ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) family, degrade cartilage oligomeric matrix protein (COMP) in vitro and are significantly induced in ...
Mary B Goldring +2 more
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Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics
Matrix Biology, 2015 The mammalian ADAMTS superfamily comprises 19 secreted metalloproteinases and 7 ADAMTS-like proteins, each the product of a distinct gene. Thus far, all appear to be relevant to extracellular matrix function or to cell-matrix interactions. Most ADAMTS functions first emerged from analysis of spontaneous human and animal mutations and genetically ...
Suneel S Apte, Johanne Dubail
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ADAMTS-4 and ADAMTS-5: Key enzymes in osteoarthritis
Journal of Cellular Biochemistry, 2011Osteoarthritis (OA) is a progressive disease of the joints characterized by degradation of articular cartilage. Although disease initiation may be multi-factorial, the cartilage destruction appears to be a result of uncontrolled proteolytic extracellular matrix destruction.
Priyanka, Verma, Krishna, Dalal
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Negative effects of ADAMTS-7 and ADAMTS-12 on endplate cartilage differentiation† [PDF]
Journal of Orthopaedic Research, 2012 AbstractThe roles of ADAMTS‐7 and ADAMTS‐12 in disc degeneration have not been previously examined. The purpose of this study was to examine the expression of ADAMTS‐7 and ADAMTS‐12 in the endplate cells isolated from patients with degenerative disc disease and to see whether they are associated with the pathological change of endplate.
Ming Ni, Xiaojie Xu
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2006
Osteoarthritis (OA) is characterized by articular cartilage erosion as a consequence of proteolytic cleavage of its two major functional macromolecules, type II collagen and aggrecan. Aggrecan degradation in OA and rheumatoid arthritis is attributed to cleavage at the Glu373-Ala374 bond by the aggrecanases.
Anne-Marie Malfait +2 more
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Osteoarthritis (OA) is characterized by articular cartilage erosion as a consequence of proteolytic cleavage of its two major functional macromolecules, type II collagen and aggrecan. Aggrecan degradation in OA and rheumatoid arthritis is attributed to cleavage at the Glu373-Ala374 bond by the aggrecanases.
Anne-Marie Malfait +2 more
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Overview of ADAMTS Proteinases and ADAMTS 2
2006Dermatosparaxis and Ehlers-Danlos syndrome type VIIC (EDS VIIC) are recessive, heritable disorders of domestic animals and humans, respectively. These phenotypes are primarily characterized by extreme fragility of the skin, and are marked by accumulation in skin of processing intermediates in the conversion of procollagen precursors into mature type I ...
Daniel S. Greenspan, Wei-Man Wang
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2022
A Disintegrin and Metalloproteinase with Thrombospondin motifs (ADAMTS) are major mediators in extracellular matrix (ECM) turnover and have gained increasing interest over the last years as major players in ECM remodeling during tissue homeostasis and the development of diseases. Although, ADAMTSs are recognized in playing important roles during tissue
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A Disintegrin and Metalloproteinase with Thrombospondin motifs (ADAMTS) are major mediators in extracellular matrix (ECM) turnover and have gained increasing interest over the last years as major players in ECM remodeling during tissue homeostasis and the development of diseases. Although, ADAMTSs are recognized in playing important roles during tissue
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Seminars in Hematology, 2004
Various assays for determination of ADAMTS-13 activity in plasma have been developed, all comprising two steps. The first step consists of proteolyzing a substrate by ADAMTS-13. Substrates were either exogenous von Willebrand factor (VWF) (purified from human plasma concentrates or recombinant VWF [rVWF]), purified VWF fragments, or endogenous VWF ...
Agnès, Veyradier, Jean-Pierre, Girma
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Various assays for determination of ADAMTS-13 activity in plasma have been developed, all comprising two steps. The first step consists of proteolyzing a substrate by ADAMTS-13. Substrates were either exogenous von Willebrand factor (VWF) (purified from human plasma concentrates or recombinant VWF [rVWF]), purified VWF fragments, or endogenous VWF ...
Agnès, Veyradier, Jean-Pierre, Girma
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Peptide Vaccine Against ADAMTS-7 Ameliorates Atherosclerosis and Postinjury Neointima Hyperplasia
Circulation, 2023Wei Kong, Qingbo Xu, Yiting Jia
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